Reactome | pS-ADRB2 [clathrin-coated endocytic vesicle membrane]

pS-ADRB2 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-HSA-8869143

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

Beta-2 adrenoceptor, RecName: Full=Beta-2 adrenergic receptor; AltName: Full=Beta-2 adrenoreceptor; Short=Beta-2 adrenoceptor;
GN Name=ADRB2; Synonyms=ADRB2R, B2AR;
OS Homo sapiens, ADRB2_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2:Catecholamine [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2:Catecholamine [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2:Catecholamine [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2:Catecholamine [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2:Catecholamine [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2:Catecholamine [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2:Catecholamine [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2:Catecholamine [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2:Catecholamine [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2:Catecholamine [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2:Catecholamine [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2:Catecholamine [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P07550 ADRB2

Gene Names

ADRB2, ADRB2R, B2AR

Chain

chain:1-413

Reference Genes

BioGPS Gene:154 ADRB2

COSMIC (genes):ADRB2 ADRB2

CTD Gene:154 ADRB2

dbSNP Gene:154 ADRB2

ENSEMBL:ENSG00000169252 ADRB2

HGNC:286 ADRB2

KEGG:hsa:154 ADRB2

Monarch:154 ADRB2

NCBI Gene:154 ADRB2

UCSC:P07550 ADRB2

Reference Transcript

RefSeq:NM_000024.5 ADRB2

Other Identifiers

11728728_s_at

154

16990848

206170_PM_at

206170_at

2834747

2834748

2834749

2834750

2834751

2834752

2834753

2834754

2834755

610_at

8109086

A_14_P117388

A_14_P200154

A_23_P145024

GE80303

GO:0001540

GO:0001993

GO:0002024

GO:0002025

GO:0002028

GO:0003012

GO:0003013

GO:0004930

GO:0004935

GO:0004941

GO:0005515

GO:0005634

GO:0005764

GO:0005768

GO:0005769

GO:0005773

GO:0005794

GO:0005886

GO:0006351

GO:0006355

GO:0006366

GO:0006898

GO:0006939

GO:0006940

GO:0007166

GO:0007171

GO:0007186

GO:0007188

GO:0007189

GO:0008179

GO:0008333

GO:0009409

GO:0010008

GO:0010739

GO:0015459

GO:0016020

GO:0016192

GO:0016324

GO:0019899

GO:0030154

GO:0030501

GO:0030669

GO:0031410

GO:0031649

GO:0040015

GO:0042802

GO:0042803

GO:0043226

GO:0043235

GO:0043410

GO:0044877

GO:0045453

GO:0045744

GO:0045944

GO:0045986

GO:0050873

GO:0051380

GO:0060089

GO:0061885

GO:0065003

GO:0071875

GO:0071880

GO:0071902

GO:0097746

GO:0098772

GO:0098992

GO:0120162

GO:1901098

GO:1904504

GO:1904646

GO:1990911

GO:2000481

GO:2000969

HMNXSV003031336

ILMN_1695590

J02960_cds1_s_at

M15169_at

PH_hs_0000339

TC05000814.hg

g13162366_3p_at

Participates

as a component of

pS-ADRB2:Catecholamine [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

ADRB2 [plasma membrane]

pS-ADRB2 [plasma membrane]

PolyUb-ADRB2 [endosome membrane]

ADRB2 [endosome membrane]

Inferred To

Homologues of pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

phospho-Octbeta3R [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

phospho-ADRB2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)

phospho-ADRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

phospho-ADRB2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

phospho-Octbeta2R [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

phospho-Octbeta1R [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

phospho-Adrb2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)

phospho-Adrb2 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-serine at unknown position

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_000015.1

ZINC - World Drugs

ADRB2_HUMAN

Guide to Pharmacology - Targets

OpenTargets

ENSG00000169252

ENSEMBL

ENSP00000305372, ENST00000305988

ZINC - FDA approved

ADRB2_HUMAN

ZINC - Substances

ADRB2_HUMAN

ZINC - Biogenic

ADRB2_HUMAN

ZINC target

P07550

PRO

P07550

GlyGen

P07550

PDB

8GE3, 8UNW, 8UHB, 8GE1, 7BZ2, 6PRZ, 8UNY, 8UO4, 2R4R, 8GE8, 8JJ8, 8GE7, 8GG7, 8GEE, 8GEG, 7XKA, 8GDZ, 8GEF, 6MXT, 8GG3, 8GEH, 8UNM, 5D5B, 6PS3, 8GGW, 8GH0, 8GGE, 6PS1, 8GFX, 8GGB, 8GGK, 8GFW, 8GGP, 6KR8, 8UNV, 3NY8, 3KJ6, 8GE2, 8JJO, 2RH1, 3PDS, 8GGZ, 6OBA, 8UO2, 8UNS, 8GFV, 8GED, 8UO1, 8GEA, 6NI3, 4LDE, 8UO0, 6PS4, 8GGO, 8GGV, 4LDO, 8GGF, 5JQH, 6PS2, 8GFZ, 8GGS, 3SN6, 8GGJ, 1GQ4, 7DHR, 8UNU, 8GE5, 7DHI, 8UO3, 8GGY, 6E67, 4QKX, 8UNQ, 5D6L, 2R4S, 8GE6, 8GG5, 8GG6, 8GEC, 8GEI, 5X7D, 8UNP, 8GG1, 7XK9, 8UNO, 8GG2, 6PS0, 5D5A, 8GGM, 8GGU, 8GGN, 4GBR, 8GGA, 8GGQ, 8GGR, 8GFY, 3P0G, 8UNX, 8GE4, 8JJL, 8UNR, 8UNZ, 8UNT, 8GGX, 3D4S, 3NYA, 8GE9, 8GEJ, 8GG4, 8GEB, 8UNN, 8GG0, 6PS5, 6PS6, 8UNL, 8GGL, 8GGT, 8GG9, 8GGC, 6N48, 8GGI, 8GH1, 8GG8, 3NY9, 4LDL

ZINC - Investigational

ADRB2_HUMAN

ZINC - Metabolites

ADRB2_HUMAN

HPA

ENSG00000169252-ADRB2

Pharos - Targets

P07550

ZINC - Predictions - Purchasable

ADRB2_HUMAN

HMDB Protein

HMDBP01634

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96B67 ARRD3			0.681	6
UniProt:P07550 ADRB2	5	ADRB2 [plasma membrane] (R-HSA-390647) pS-ADRB2 [plasma membrane] (R-HSA-8852158) PolyUb-ADRB2 [endosome membrane] (R-HSA-6783066) ADRB2 [endosome membrane] (R-HSA-6783036) pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869143)	0.657	4
UniProt:Q5TCQ9 MAGI3			0.619	9
UniProt:P04896 GNAS2			0.612	4
UniProt:P54311 Gnb1	3	Gnb1 [cytosol] (R-RNO-6814412) G-protein beta 1 subunit [plasma membrane] (R-RNO-421797) Gnb1 [photoreceptor disc membrane] (R-RNO-55373)	0.612	4
UniProt:P63212 GNG2	1	GNG2 [plasma membrane] (R-BTA-9717212)	0.612	4
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.611	3
UniProt:P30542 ADORA1	1	ADORA1 [plasma membrane] (R-HSA-418941)	0.61	5
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.608	3
UniProt:O14745 NHRF1			0.558	6
UniProt:A0AVK6 E2F8	1	E2F8 [nucleoplasm] (R-HSA-8952990)	0.556	3
UniProt:Q9ULD4-2 Q9ULD42			0.556	3
UniProt:Q15486 GUSP1			0.556	3
UniProt:Q9NSI6-4 BRWD1			0.556	3
UniProt:Q9UII2 ATIF1			0.556	3
UniProt:Q8N0U2 TMM61			0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:Q658K8 EF1DL			0.556	3
UniProt:Q5M9N0-2 CCDC158			0.556	3
UniProt:Q8WVD3 RNF138	1	RNF138 [cytosol] (R-HSA-976008)	0.556	3
UniProt:Q9NR21-5 PARP11			0.556	3
UniProt:Q9H0X6 RN208			0.556	3
UniProt:Q15910-2 EZH2			0.556	3
UniProt:O00472 ELL2	1	ELL2 [nucleoplasm] (R-HSA-6807506)	0.556	3
UniProt:Q5T0J7-2 TEX35			0.556	3
UniProt:P61978 HNRNPK	2	HNRNPK [nucleoplasm] (R-HSA-71945) polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.508	2
UniProt:Q99685 MGLL	3	MGLL [plasma membrane] (R-HSA-426055) MGLL [lipid droplet] (R-HSA-163567) MGLL [endoplasmic reticulum membrane] (R-HSA-1500589)	0.508	2
UniProt:Q14232 EIF2B1	1	EIF2B1 [cytosol] (R-HSA-72517)	0.463	2
UniProt:P02686 MBP	1	MBP [cytosol] (R-HSA-9614770)	0.454	2
UniProt:P04156 PRNP	2	PRNP [cytosol] (R-HSA-9617597) PRNP [plasma membrane] (R-HSA-375060)	0.454	2

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