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PHGDH [cytosol]
Stable Identifier
R-HSA-977340
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
D-3-phosphoglycerate dehydrogenase, SERA_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Serine biosynthesis (Homo sapiens)
PHGDH tetramer dehydrogenates 3PG (Homo sapiens)
PHGDH tetramer [cytosol] (Homo sapiens)
PHGDH [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43175 PHGDH
Gene Names
PHGDH, PGD, PGDH3
Chain
initiator methionine:, chain:2-533
Reference Genes
BioGPS Gene:26227 PHGDH
COSMIC (genes):PHGDH PHGDH
CTD Gene:26227 PHGDH
dbSNP Gene:26227 PHGDH
ENSEMBL:ENSG00000092621 PHGDH
ENSEMBL_homo_sapiens_GENE:ENSG00000092621.13 PHGDH
HGNC:8923 PHGDH
KEGG Gene (Homo sapiens):26227 PHGDH
Monarch:26227 PHGDH
NCBI Gene:26227 PHGDH
OMIM:606879 PHGDH
UCSC:O43175 PHGDH
Reference Transcript
RefSeq:NM_006623.3 PHGDH
Other Identifiers
11728203_a_at
16669389
201397_PM_at
201397_at
2354629
2354639
2354641
2354642
2354651
2354652
2354655
2354660
2354662
2354675
2354676
2354677
2354682
2354689
2354690
2354695
2354696
2354698
2354699
26227
34367_at
63911_at
7904433
GE81662
GO:0003824
GO:0004617
GO:0005576
GO:0005615
GO:0005829
GO:0006091
GO:0006520
GO:0006541
GO:0006544
GO:0006563
GO:0006564
GO:0006566
GO:0006790
GO:0007420
GO:0008652
GO:0009055
GO:0009448
GO:0010468
GO:0016491
GO:0016616
GO:0019530
GO:0021510
GO:0021782
GO:0021915
GO:0022008
GO:0022900
GO:0030060
GO:0030154
GO:0031175
GO:0043226
GO:0048856
GO:0051287
GO:0070062
GO:0070314
HMNXSV003047523
ILMN_1704537
PH_hs_0000404
TC01001043.hg
g5729973_3p_at
Participates
as a component of
PHGDH tetramer [cytosol] (Homo sapiens)
Inferred To
LOC119863969 [cytosol]
(Canis familiaris)
phgdh [cytosol]
(Xenopus tropicalis)
GH26 [cytosol]
(Drosophila melanogaster)
phdh-1 [cytosol]
(Caenorhabditis elegans)
LOC119863976 [cytosol]
(Canis familiaris)
PHGDH [cytosol]
(Bos taurus)
PHGDH [cytosol]
(Mus musculus)
PHGDH [cytosol]
(Rattus norvegicus)
PHGDH [cytosol]
(Sus scrofa)
Homologues of PHGDH [cytosol]
(Canis familiaris)
Cross References
RefSeq
NP_006614.2
OpenTargets
ENSG00000092621
IntEnz
1.1.1.37
,
1.1.1.399
,
1.1.1.95
HPA
ENSG00000092621-PHGDH
GeneCards
O43175
Ensembl
ENSP00000493382
,
ENST00000641023
,
ENSP00000493175
,
ENST00000641597
,
ENSG00000092621
PRO
O43175
Pharos - Targets
O43175
Orphanet
15084
HMDB Protein
HMDBP00922
PDB
6CWA
,
6RJ5
,
7DKM
,
6RJ2
,
6PLG
,
2G76
,
5OFW
,
5OFM
,
7CVP
,
6RIH
,
5OFV
,
6RJ3
,
6PLF
,
5NZO
,
6RJ6
,
5NZQ
,
5NZP
,
5N6C
,
5N53
,
7EWH
,
7VA1
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
12
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.527
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
4
UniProt:P11440 Cdk1
11
phospho-p-T161-CDK1 [nucleoplasm]
(R-MMU-170066)
phospho-p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-MMU-170074)
phospho-p-T161-CDK1 [cytosol]
(R-MMU-157415)
phospho-p-T14,Y15,T161-CDK1 [cytosol]
(R-MMU-170071)
CDK1 [cytosol]
(R-MMU-170075)
phospho-p-T14-CDK1 [cytosol]
(R-MMU-170064)
phospho-p-T14-CDK1 [nucleoplasm]
(R-MMU-170045)
Cdk1 [nucleoplasm]
(R-MMU-1362302)
phospho-p-T14,T161-CDK1 [nucleoplasm]
(R-MMU-170078)
phospho-p-Y4-CDK1 [cytosol]
(R-MMU-9836187)
CDK1 [endoplasmic reticulum membrane]
(R-MMU-264424)
0.499
2
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