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PHGDH [cytosol]
Stable Identifier
R-HSA-977340
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
D-3-phosphoglycerate dehydrogenase, SERA_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Serine metabolism (Homo sapiens)
PHGDH tetramer dehydrogenates 3PG (Homo sapiens)
PHGDH tetramer [cytosol] (Homo sapiens)
PHGDH [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43175 PHGDH
Gene Names
PHGDH, PGD, PGDH3
Chain
initiator methionine:, chain:2-533
Reference Genes
BioGPS Gene:26227 PHGDH
COSMIC (genes):PGD PGD
COSMIC (genes):PHGDH PHGDH
CTD Gene:26227 PHGDH
dbSNP Gene:26227 PHGDH
ENSEMBL:ENSG00000092621 PHGDH
HGNC:8923 PHGDH
KEGG:hsa:26227 PHGDH
Monarch:26227 PHGDH
NCBI Gene:26227 PHGDH
OMIM:606879 PHGDH
UCSC:O43175 PHGDH
Reference Transcript
RefSeq:NM_006623.3 PHGDH
Other Identifiers
11728203_a_at
16669389
201397_PM_at
201397_at
2354629
2354635
2354639
2354640
2354641
2354642
2354643
2354644
2354645
2354646
2354647
2354648
2354649
2354650
2354651
2354652
2354653
2354654
2354655
2354656
2354657
2354659
2354660
2354661
2354662
2354663
2354664
2354666
2354667
2354668
2354674
2354675
2354676
2354677
2354678
2354679
2354680
2354681
2354682
2354686
2354687
2354688
2354689
2354690
2354691
2354692
2354693
2354694
2354695
2354696
2354697
2354698
2354699
26227
34367_at
62861_at
63911_at
7904433
A_14_P136327
A_14_P137987
GE693993
GE81662
GO:0003824
GO:0004617
GO:0005515
GO:0005829
GO:0006520
GO:0006541
GO:0006544
GO:0006563
GO:0006564
GO:0006566
GO:0006790
GO:0007420
GO:0008652
GO:0009055
GO:0009448
GO:0010468
GO:0016491
GO:0016616
GO:0019530
GO:0021510
GO:0021782
GO:0021915
GO:0022008
GO:0030060
GO:0030154
GO:0031175
GO:0043226
GO:0048856
GO:0051287
GO:0070062
GO:0070314
HMNXSV003047523
ILMN_1704537
PH_hs_0000404
TC01001043.hg
g5729973_3p_at
Participates
as a component of
PHGDH tetramer [cytosol] (Homo sapiens)
Inferred To
Phgdh [cytosol]
(Drosophila melanogaster)
LOC119863969 [cytosol]
(Canis familiaris)
phgdh [cytosol]
(Xenopus tropicalis)
phdh-1 [cytosol]
(Caenorhabditis elegans)
LOC119863976 [cytosol]
(Canis familiaris)
PHGDH [cytosol]
(Bos taurus)
PHGDH [cytosol]
(Mus musculus)
PHGDH [cytosol]
(Rattus norvegicus)
PHGDH [cytosol]
(Sus scrofa)
Homologues of PHGDH [cytosol]
(Canis familiaris)
Cross References
RefSeq
NP_006614.2
OpenTargets
ENSG00000092621
ENSEMBL
ENSP00000493175
,
ENSP00000493382
,
ENST00000641597
,
ENST00000641023
,
ENSG00000092621
IntEnz
1.1.1.95
,
1.1.1.399
,
1.1.1.37
HPA
ENSG00000092621-PHGDH
GeneCards
PHGDH
PRO
O43175
Pharos - Targets
O43175
Orphanet
PHGDH
GlyGen
O43175
HMDB Protein
HMDBP00922
PDB
5OFW
,
5OFV
,
6RJ3
,
2G76
,
5NZQ
,
6PLG
,
6PLF
,
6RJ2
,
7CVP
,
5NZP
,
5NZO
,
5N53
,
7VA1
,
7DKM
,
6RJ5
,
5N6C
,
6RIH
,
7EWH
,
6CWA
,
5OFM
,
6RJ6
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y6I3 EPN1
2
EPN1 [cytosol]
(R-HSA-8865826)
EPN1 [plasma membrane]
(R-HSA-182952)
0.708
5
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
12
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.527
3
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
4
UniProt:P11440 Cdk1
11
phospho-p-T161-CDK1 [nucleoplasm]
(R-MMU-170066)
phospho-p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-MMU-170074)
phospho-p-T161-CDK1 [cytosol]
(R-MMU-157415)
phospho-p-T14,Y15,T161-CDK1 [cytosol]
(R-MMU-170071)
CDK1 [cytosol]
(R-MMU-170075)
Cdk1 [nucleoplasm]
(R-MMU-1362302)
phospho-p-T14,T161-CDK1 [nucleoplasm]
(R-MMU-170078)
phospho-p-T14-CDK1 [nucleoplasm]
(R-MMU-170045)
phospho-p-T14-CDK1 [cytosol]
(R-MMU-170064)
phospho-p-Y4-CDK1 [cytosol]
(R-MMU-9836187)
CDK1 [endoplasmic reticulum membrane]
(R-MMU-264424)
0.499
2
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