Reactome | PHGDH [cytosol]

PHGDH [cytosol]

Stable Identifier

R-HSA-977340

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

D-3-phosphoglycerate dehydrogenase, SERA_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O43175 PHGDH

Gene Names

PHGDH, PGD, PGDH3

Chain

initiator methionine:, chain:2-533

Reference Genes

BioGPS Gene:26227 PHGDH

COSMIC (genes):PGD PGD

COSMIC (genes):PHGDH PHGDH

CTD Gene:26227 PHGDH

dbSNP Gene:26227 PHGDH

ENSEMBL:ENSG00000092621 PHGDH

HGNC:8923 PHGDH

KEGG:hsa:26227 PHGDH

Monarch:26227 PHGDH

NCBI Gene:26227 PHGDH

OMIM:606879 PHGDH

UCSC:O43175 PHGDH

Reference Transcript

RefSeq:NM_006623.3 PHGDH

Other Identifiers

11728203_a_at

16669389

201397_PM_at

201397_at

2354629

2354635

2354639

2354640

2354641

2354642

2354643

2354644

2354645

2354646

2354647

2354648

2354649

2354650

2354651

2354652

2354653

2354654

2354655

2354656

2354657

2354659

2354660

2354661

2354662

2354663

2354664

2354666

2354667

2354668

2354674

2354675

2354676

2354677

2354678

2354679

2354680

2354681

2354682

2354686

2354687

2354688

2354689

2354690

2354691

2354692

2354693

2354694

2354695

2354696

2354697

2354698

2354699

26227

34367_at

62861_at

63911_at

7904433

A_14_P136327

A_14_P137987

GE693993

GE81662

GO:0003824

GO:0004617

GO:0005515

GO:0005829

GO:0006520

GO:0006541

GO:0006544

GO:0006563

GO:0006564

GO:0006566

GO:0006790

GO:0007420

GO:0008652

GO:0009055

GO:0009448

GO:0010468

GO:0016491

GO:0016616

GO:0019530

GO:0021510

GO:0021782

GO:0021915

GO:0022008

GO:0030060

GO:0030154

GO:0031175

GO:0043226

GO:0048856

GO:0051287

GO:0070062

GO:0070314

HMNXSV003047523

ILMN_1704537

PH_hs_0000404

TC01001043.hg

g5729973_3p_at

Participates

as a component of

PHGDH tetramer [cytosol] (Homo sapiens)

Inferred To

Phgdh [cytosol] (Drosophila melanogaster)

LOC119863969 [cytosol] (Canis familiaris)

phgdh [cytosol] (Xenopus tropicalis)

phdh-1 [cytosol] (Caenorhabditis elegans)

LOC119863976 [cytosol] (Canis familiaris)

PHGDH [cytosol] (Bos taurus)

PHGDH [cytosol] (Mus musculus)

PHGDH [cytosol] (Rattus norvegicus)

PHGDH [cytosol] (Sus scrofa)

Homologues of PHGDH [cytosol] (Canis familiaris)

Cross References

RefSeq

NP_006614.2

OpenTargets

ENSG00000092621

ENSEMBL

ENSP00000493175, ENSP00000493382, ENST00000641597, ENST00000641023, ENSG00000092621

IntEnz

1.1.1.95, 1.1.1.399, 1.1.1.37

HPA

ENSG00000092621-PHGDH

GeneCards

PHGDH

PRO

O43175

Pharos - Targets

O43175

Orphanet

PHGDH

GlyGen

O43175

HMDB Protein

HMDBP00922

PDB

5OFW, 5OFV, 6RJ3, 2G76, 5NZQ, 6PLG, 6PLF, 6RJ2, 7CVP, 5NZP, 5NZO, 5N53, 7VA1, 7DKM, 6RJ5, 5N6C, 6RIH, 7EWH, 6CWA, 5OFM, 6RJ6

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y6I3 EPN1	2	EPN1 [cytosol] (R-HSA-8865826) EPN1 [plasma membrane] (R-HSA-182952)	0.708	5
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	12
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:P11440 Cdk1	11	phospho-p-T161-CDK1 [nucleoplasm] (R-MMU-170066) phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (R-MMU-170074) phospho-p-T161-CDK1 [cytosol] (R-MMU-157415) phospho-p-T14,Y15,T161-CDK1 [cytosol] (R-MMU-170071) CDK1 [cytosol] (R-MMU-170075) Cdk1 [nucleoplasm] (R-MMU-1362302) phospho-p-T14,T161-CDK1 [nucleoplasm] (R-MMU-170078) phospho-p-T14-CDK1 [nucleoplasm] (R-MMU-170045) phospho-p-T14-CDK1 [cytosol] (R-MMU-170064) phospho-p-Y4-CDK1 [cytosol] (R-MMU-9836187) CDK1 [endoplasmic reticulum membrane] (R-MMU-264424)	0.499	2

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