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TAPBP [integral component of lumenal side of endoplasmic reticulum membrane]
Stable Identifier
R-HSA-983083
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
integral component of lumenal side of endoplasmic reticulum membrane
Synonyms
Tapasin, TPSN_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Homo sapiens)
Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Homo sapiens)
Antigenic peptide:MHC:B2M peptide loading complex [endoplasmic reticulum membrane] (Homo sapiens)
MHC:B2M peptide loading complex [endoplasmic reticulum membrane] (Homo sapiens)
TAPBP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
TAPBP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
Formation of peptide loading complex (PLC) (Homo sapiens)
MHC:B2M peptide loading complex [endoplasmic reticulum membrane] (Homo sapiens)
TAPBP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
TAPBP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
Loading of antigenic peptides on to class I MHC (Homo sapiens)
Antigenic peptide:MHC:B2M peptide loading complex [endoplasmic reticulum membrane] (Homo sapiens)
MHC:B2M peptide loading complex [endoplasmic reticulum membrane] (Homo sapiens)
TAPBP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
MHC:B2M peptide loading complex [endoplasmic reticulum membrane] (Homo sapiens)
TAPBP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
ER-Phagosome pathway (Homo sapiens)
Transport of SEC22B, TAP and PLC from ER to ERGIC (Homo sapiens)
TAPBP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15533 TAPBP
Gene Names
TAPBP, NGS17, TAPA
Chain
signal peptide:1-20, chain:21-448
Reference Genes
BioGPS Gene:6892 TAPBP
COSMIC (genes):TAPBP TAPBP
CTD Gene:6892 TAPBP
dbSNP Gene:6892 TAPBP
ENSEMBL:ENSG00000112493 TAPBP
ENSEMBL:ENSG00000206208 TAPBP
ENSEMBL:ENSG00000206281 TAPBP
ENSEMBL:ENSG00000231925 TAPBP
ENSEMBL:ENSG00000236490 TAPBP
HGNC:11566 TAPBP
KEGG Gene (Homo sapiens):6892 TAPBP
Monarch:6892 TAPBP
NCBI Gene:6892 TAPBP
OMIM:601962 TAPBP
UCSC:O15533 TAPBP
Reference Transcript
RefSeq:NM_003190.4 TAPBP
RefSeq:NM_172209.2 TAPBP
RefSeq:NM_172208.2 TAPBP
Other Identifiers
0002030358
0004200593
0005390110
0006200333
11735502_a_at
11751572_a_at
11756617_a_at
11756618_x_at
11757321_a_at
1555565_PM_s_at
1555565_s_at
17018215
17030026
17032710
17037511
17040221
208829_PM_at
208829_at
210294_PM_at
210294_at
213081_PM_at
213081_at
2950621
2950622
2950623
2950624
2950625
2950626
2950628
2950630
2950634
2950635
2950638
2950641
2950642
2950645
2950649
2950650
2950651
2950652
2950654
2950655
2950657
34178_at
41168_at
6892
74637_at
8125713
8178977
8180166
A_23_P259580
A_23_P315336
A_23_P365719
A_33_P3325914
GE54224
GE87404
GO:0000139
GO:0002376
GO:0002397
GO:0002398
GO:0002502
GO:0003674
GO:0003823
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005783
GO:0005789
GO:0005794
GO:0006810
GO:0006890
GO:0006955
GO:0008150
GO:0010468
GO:0015433
GO:0015833
GO:0016020
GO:0016021
GO:0016192
GO:0019885
GO:0022607
GO:0022857
GO:0030670
GO:0031410
GO:0032991
GO:0033116
GO:0034641
GO:0042288
GO:0042605
GO:0042824
GO:0043226
GO:0046978
GO:0046979
GO:0050776
GO:0050823
GO:0051082
GO:0061635
GO:0061779
GO:0062061
GO:0065003
GO:0071556
GO:0140657
HMNXSV003028171
HMNXSV003038859
Hs.206770.0.S2_3p_at
Hs2.370937.6.S1_3p_s_at
ILMN_1742450
ILMN_1773031
ILMN_1782851
ILMN_3241524
PH_hs_0017822
TC06001584.hg
TC6_cox_hap2000208.hg
TC6_dbb_hap3000194.hg
TC6_mcf_hap5000183.hg
TC6_qbl_hap6000196.hg
g10803729_3p_at
g2587057_3p_at
Participates
as an input of
Transport of SEC22B, TAP and PLC from ER to ERGIC (Homo sapiens)
Formation of peptide loading complex (PLC) (Homo sapiens)
as an output of
Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Homo sapiens)
as a component of
MHC:B2M peptide loading complex [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
TAPBP [phagocytic vesicle membrane]
TAPBP [endoplasmic reticulum-Golgi intermediate compartment membrane]
Inferred To
Ghost homologue of TAPBP [integral component of lumenal side of endoplasmic reticulum membrane]
(Sus scrofa)
Tapbp [integral component of lumenal side of endoplasmic reticulum membrane]
(Mus musculus)
Tapbp [integral component of lumenal side of endoplasmic reticulum membrane]
(Rattus norvegicus)
TAPBP [integral component of lumenal side of endoplasmic reticulum membrane]
(Bos taurus)
TAPBP [integral component of lumenal side of endoplasmic reticulum membrane]
(Canis familiaris)
TPN [integral component of lumenal side of endoplasmic reticulum membrane]
(Gallus gallus)
tapbpl [integral component of lumenal side of endoplasmic reticulum membrane]
(Danio rerio)
tapbpl [integral component of lumenal side of endoplasmic reticulum membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_003181.3
,
NP_757345.2
,
NP_757346.2
OpenTargets
ENSG00000231925
GeneCards
O15533
HPA
ENSG00000231925-TAPBP
Ensembl
ENST00000434618
,
ENSP00000378546
,
ENST00000456807
,
ENST00000383197
,
ENST00000383198
,
ENST00000417059
,
ENSP00000363700
,
ENSP00000372543
,
ENSP00000395701
,
ENSP00000372685
,
ENSG00000112493
,
ENST00000395114
,
ENST00000383066
,
ENSP00000407195
,
ENSP00000402087
,
ENSP00000372684
,
ENSG00000231925
,
ENSG00000236490
,
ENSG00000206281
,
ENST00000374572
,
ENSG00000206208
PRO
O15533
Pharos - Targets
O15533
Orphanet
16437
PDB
6ENY
,
3F8U
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q03518 TAP1
3
TAP1 [phagocytic vesicle membrane]
(R-HSA-1236845)
TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863953)
TAP1 [endoplasmic reticulum membrane]
(R-HSA-947474)
0.803
14
UniProt:P01892 HLA-A
9
K48polyUb-HLA-A A-2 [endoplasmic reticulum membrane]
(R-HSA-8943073)
HLA-A A-2 [endoplasmic reticulum membrane]
(R-HSA-8943104)
HLA class I histocompatibility antigen, A-2 alpha chain [ER to Golgi transport vesicle membrane]
(R-HSA-983389)
HLA class I histocompatibility antigen, A-2 alpha chain [Golgi membrane]
(R-HSA-182252)
HLA class I histocompatibility antigen, A-2 alpha chain [phagocytic vesicle membrane]
(R-HSA-1236884)
HLA class I histocompatibility antigen, A-2 alpha chain [recycling endosome membrane]
(R-HSA-8863857)
HLA class I histocompatibility antigen, A-2 alpha chain [plasma membrane]
(R-HSA-198892)
HLA class I histocompatibility antigen, A-2 alpha chain [early endosome membrane]
(R-HSA-182267)
HLA class I histocompatibility antigen, A-2 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-983075)
0.688
10
UniProt:Q03519 TAP2
3
TAP2 [phagocytic vesicle membrane]
(R-HSA-1236821)
TAP2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863947)
TAP2 [endoplasmic reticulum membrane]
(R-HSA-947475)
0.677
8
UniProt:P0C739 BNL2A
0.623
6
UniProt:Q77CE4 GN
0.564
2
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