Reactome | p-S446-IRF5 [nucleoplasm]

p-S446-IRF5 [nucleoplasm]

Stable Identifier

R-HSA-9860304

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-S446-IRF5_HUMAN, Interferon regulatory factor 5

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13568 IRF5

Gene Names

IRF5

Chain

chain:1-498

Reference Genes

BioGPS Gene:3663 IRF5

COSMIC (genes):IRF5 IRF5

CTD Gene:3663 IRF5

dbSNP Gene:3663 IRF5

ENSEMBL:ENSG00000128604 IRF5

HGNC:6120 IRF5

KEGG:hsa:3663 IRF5

Monarch:3663 IRF5

NCBI Gene:3663 IRF5

OMIM:607218 IRF5

UCSC:Q13568 IRF5

Reference Transcript

Other Identifiers

11726685_a_at

11726686_a_at

11726687_a_at

11746801_x_at

11752974_a_at

11762306_a_at

17051347

205468_PM_s_at

205468_s_at

205469_PM_s_at

205469_s_at

239412_PM_at

239412_at

3023247

3023248

3023250

3023251

3023252

3023253

3023254

3023255

3023256

3023257

3023258

3023259

3023260

3023261

3023262

3023263

3023264

36465_at

3663

477_at

478_g_at

8136045

A_14_P120116

A_23_P500271

A_24_P363609

GE59217

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001228

GO:0002376

GO:0002720

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0006357

GO:0006954

GO:0019221

GO:0019901

GO:0032481

GO:0032494

GO:0032495

GO:0032727

GO:0032728

GO:0032735

GO:0042802

GO:0043065

GO:0043226

GO:0043565

GO:0045087

GO:0045944

GO:0051607

GO:0098542

GO:0098586

GO:0140110

GO:1990837

HMNXSV003027868

Hs.232644.0.A1_3p_at

Hs.54434.0.S1_3p_a_at

ILMN_1670576

ILMN_2312606

PH_hs_0016421

TC07000789.hg

U51127_at

g4504726_3p_a_at

Participates

as a component of

p-S446-IRF5:p-S446-IRF5 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

IRF5 [cytosol]

p-S446-IRF5 [cytosol]

Inferred To

phospho-Irf5 [nucleoplasm] (Mus musculus)

phospho-Irf5 [nucleoplasm] (Rattus norvegicus)

phospho-irf5 [nucleoplasm] (Danio rerio)

phospho-IRF5 [nucleoplasm] (Bos taurus)

phospho-IRF5 [nucleoplasm] (Canis familiaris)

phospho-IRF5 [nucleoplasm] (Gallus gallus)

phospho-IRF5 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at 446

Coordinate

446

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001334857.1, XP_006716037.1, XP_011514466.1, NP_001092100.1, NP_001092097.2, XP_011514465.1, XP_011514463.1, XP_011514461.1, NP_116032.1, NP_001092099.1, XP_011514462.1, XP_011514464.1, XP_011514460.1, NP_001229381.1, XP_005250374.1

OpenTargets

ENSG00000128604

ENSEMBL

ENSP00000385352, ENST00000489702, ENST00000465603, ENST00000473745, ENST00000477535, ENSP00000419950, ENST00000402030, ENST00000357234, ENSP00000418037, ENSP00000418534, ENSP00000419149, ENSP00000349770

HPA

ENSG00000128604-IRF5

PRO

Q13568

Pharos - Targets

Q13568

Orphanet

IRF5

GlyGen

Q13568

PDB

3DSH

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.656	6
UniProt:Q92793 CREBBP	4	CREBBP [nucleoplasm] (R-HSA-193545) CREBBP [cytosol] (R-HSA-9756493) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877)	0.618	3
UniProt:Q13568 IRF5	3	IRF5 [cytosol] (R-HSA-1015676) p-S446-IRF5 [cytosol] (R-HSA-9860271) p-S446-IRF5 [nucleoplasm] (R-HSA-9860304)	0.618	3
UniProt:O94986 CEP152	1	CEP152 [cytosol] (R-HSA-380277)	0.574	3
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.543	3
UniProt:Q13263 TRIM28	3	TRIM28 [nucleoplasm] (R-HSA-974998) SUMO2-K554,K575,K676,K750,K779,K804-TRIM28 [nucleoplasm] (R-HSA-9842867) SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm] (R-HSA-3782600)	0.524	5
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.499	2
UniProt:Q8N697 SLC15A4	4	SLC15A4 [lysosomal membrane] (R-HSA-428039) SLC15A4 [endolysosome membrane] (R-HSA-9860282) SLC15A4 [plasma membrane] (R-HSA-6800447) SLC15A4 [specific granule membrane] (R-HSA-6799715)	0.462	2

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