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Pik3r1 [plasma membrane]
Stable Identifier
R-MMU-198365
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
plasma membrane
Synonyms
PIK3R1, P26450
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Signaling by the B Cell Receptor (BCR) (Mus musculus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Mus musculus)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)
BCAP Signalosome [plasma membrane] (Mus musculus)
PIK3CD:PIK3R1 [plasma membrane] (Mus musculus)
Pik3r1 [plasma membrane] (Mus musculus)
PIK3CD:PIK3R1 [plasma membrane] (Mus musculus)
Pik3r1 [plasma membrane] (Mus musculus)
CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)
CD19 Signalosome [plasma membrane] (Mus musculus)
PIK3CD:PIK3R1 [plasma membrane] (Mus musculus)
Pik3r1 [plasma membrane] (Mus musculus)
PIK3CD:PIK3R1 [plasma membrane] (Mus musculus)
Pik3r1 [plasma membrane] (Mus musculus)
p-CD19:VAV binds PI3K and GRB2 (Mus musculus)
CD19 Signalosome [plasma membrane] (Mus musculus)
PIK3CD:PIK3R1 [plasma membrane] (Mus musculus)
Pik3r1 [plasma membrane] (Mus musculus)
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
Negative regulation of the PI3K/AKT network (Mus musculus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activator:PI3K [plasma membrane] (Mus musculus)
BCAP Signalosome [plasma membrane] (Mus musculus)
PIK3CD:PIK3R1 [plasma membrane] (Mus musculus)
Pik3r1 [plasma membrane] (Mus musculus)
CD19 Signalosome [plasma membrane] (Mus musculus)
PIK3CD:PIK3R1 [plasma membrane] (Mus musculus)
Pik3r1 [plasma membrane] (Mus musculus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Pik3r1 [plasma membrane] (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Mus musculus)
Pik3r1 [plasma membrane] (Mus musculus)
PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
Activator:PI3K [plasma membrane] (Mus musculus)
BCAP Signalosome [plasma membrane] (Mus musculus)
PIK3CD:PIK3R1 [plasma membrane] (Mus musculus)
Pik3r1 [plasma membrane] (Mus musculus)
CD19 Signalosome [plasma membrane] (Mus musculus)
PIK3CD:PIK3R1 [plasma membrane] (Mus musculus)
Pik3r1 [plasma membrane] (Mus musculus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Pik3r1 [plasma membrane] (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Mus musculus)
Pik3r1 [plasma membrane] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ERBB2 (Mus musculus)
PI3K events in ERBB2 signaling (Mus musculus)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Mus musculus)
Pik3r1 [plasma membrane] (Mus musculus)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Mus musculus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Pik3r1 [plasma membrane] (Mus musculus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Mus musculus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Mus musculus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Pik3r1 [plasma membrane] (Mus musculus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Mus musculus)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Mus musculus)
Pik3r1 [plasma membrane] (Mus musculus)
External Reference Information
External Reference
UniProt:P26450 Pik3r1
Gene Names
Pik3r1
Chain
initiator methionine:, chain:2-724
Reference Genes
BioGPS Gene:18708 Pik3r1
ENSEMBL:ENSMUSG00000041417.16 Pik3r1
KEGG Gene (Mus musculus):18708 Pik3r1
Monarch:18708 Pik3r1
NCBI Gene:18708 Pik3r1
UCSC:P26450 Pik3r1
Reference Transcript
RefSeq:NM_001077495.2 Pik3r1
Other Identifiers
10411782
113019_at
129853_at
1425514_at
1425515_at
1438682_at
1451737_at
163548_at
17295796
18708
4488390
4509795
4574844
4584747
4627475
4630640
4670222
4701241
4723068
4754477
4792657
4803871
4813365
5041143
5109065
5110986
5173919
5293013
5338577
5432805
5450486
5452837
5519462
96592_at
A_51_P511236
A_52_P235476
A_52_P307938
A_52_P407239
GE1396611
GE33132
GO:0001678
GO:0001784
GO:0001934
GO:0001953
GO:0002376
GO:0002687
GO:0003013
GO:0003824
GO:0005102
GO:0005158
GO:0005159
GO:0005161
GO:0005168
GO:0005515
GO:0005516
GO:0005634
GO:0005737
GO:0005783
GO:0005794
GO:0005801
GO:0005829
GO:0005911
GO:0005942
GO:0005943
GO:0005975
GO:0006006
GO:0006351
GO:0006355
GO:0006366
GO:0006606
GO:0006629
GO:0006886
GO:0006913
GO:0007010
GO:0007155
GO:0007162
GO:0007165
GO:0008286
GO:0008625
GO:0008630
GO:0010459
GO:0010592
GO:0010628
GO:0010656
GO:0012501
GO:0015031
GO:0016020
GO:0016303
GO:0016740
GO:0019209
GO:0019221
GO:0019901
GO:0019903
GO:0019904
GO:0022408
GO:0023052
GO:0030154
GO:0030183
GO:0030316
GO:0030331
GO:0030335
GO:0030971
GO:0031625
GO:0032760
GO:0032868
GO:0032869
GO:0032991
GO:0033120
GO:0034143
GO:0034330
GO:0034644
GO:0034976
GO:0035014
GO:0035655
GO:0036092
GO:0036211
GO:0036312
GO:0042307
GO:0043066
GO:0043125
GO:0043226
GO:0043491
GO:0043559
GO:0043560
GO:0045663
GO:0045671
GO:0045776
GO:0045861
GO:0045944
GO:0046488
GO:0046854
GO:0046935
GO:0046982
GO:0048009
GO:0048471
GO:0048661
GO:0048662
GO:0048856
GO:0048870
GO:0050821
GO:0051117
GO:0051219
GO:0051384
GO:0051491
GO:0051492
GO:0051497
GO:0051591
GO:0051965
GO:0060396
GO:0072659
GO:0097529
GO:0098542
GO:0098772
GO:0120183
GO:1900103
GO:1903076
GO:1990578
ILMN_1249335
ILMN_2473531
ILMN_3040050
ILMN_3114641
mMR026375
u50413_s_at
Participates
as a component of
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Mus musculus)
PIK3CD:PIK3R1 [plasma membrane] (Mus musculus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Mus musculus)
Other forms of this molecule
p-Y-Pik3r1 [cytosol]
Pik3r1 [cytosol]
Pi3k-p85 alpha [cytosol]
Pik3r1 [cytosol]
Inferred From
PIK3R1 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
NP_001070963.1
Ensembl
ENSMUSP00000056774
,
ENSMUST00000055518
,
ENSMUSG00000041417
PRO
P26450
MGI
97583
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35569 Irs1
8
p-Irs1 [cytosol]
(R-MMU-2671869)
phospho-Irs1 [plasma membrane]
(R-MMU-2445090)
Irs1 [plasma membrane]
(R-MMU-2425392)
Phospho-IRS1 (by NTRK1) [cytosol]
(R-MMU-198285)
Irs1 [cytosol]
(R-MMU-198257)
Irs1 [cytosol]
(R-MMU-74769)
phospho-Irs1 [cytosol]
(R-MMU-74772)
phospho-Irs1 [plasma membrane]
(R-MMU-198366)
0.702
3
UniProt:Q8BTI9 Pik3cb
2
Pik3cb [cytosol]
(R-MMU-9027217)
Pik3cb [cytosol]
(R-MMU-74788)
0.573
5
UniProt:P42337 Pik3ca
1
Pik3ca [cytosol]
(R-MMU-9027214)
0.573
7
UniProt:Q8IZP0 ABI1
2
p-5S-ABI1 [cytosol]
(R-HSA-2029034)
ABI1 [cytosol]
(R-HSA-1671643)
0.524
3
UniProt:Q8R5H6
3
Wasf1 [cytosol]
(R-MMU-200965)
phospho-Wasf1 [cytosol]
(R-MMU-5672390)
phospho-Wasf1 [cytosol]
(R-MMU-2029058)
0.499
2
UniProt:Q9WVS0
2
Icos [plasma membrane]
(R-MMU-198144)
phospho-Icos [plasma membrane]
(R-MMU-389927)
0.499
2
UniProt:Q7TMB8
5
Cyfip1 [specific granule lumen]
(R-MMU-6800167)
Cyfip1 [secretory granule lumen]
(R-MMU-6800940)
Cyfip1 [extracellular region]
(R-MMU-6800473)
Cyfip1 [tertiary granule lumen]
(R-MMU-6800176)
Cyfip1 [cytosol]
(R-MMU-5672575)
0.462
2
UniProt:P28660
1
Nckap1 [cytosol]
(R-MMU-200979)
0.462
2
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
0.462
2
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