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APP(672-711) [extracellular region]
Stable Identifier
R-MMU-976740
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
extracellular region
Synonyms
P12023
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Mus musculus)
ECM proteoglycans (Mus musculus)
AGRN binds Beta amyloid fibril via GAG chains (Mus musculus)
AGRN:Beta amyloid fibril [extracellular region] (Mus musculus)
Beta amyloid fibril [extracellular region] (Mus musculus)
APP(672-713), APP(672-711) [extracellular region] (Mus musculus)
APP(672-711) [extracellular region] (Mus musculus)
Beta amyloid fibril [extracellular region] (Mus musculus)
APP(672-713), APP(672-711) [extracellular region] (Mus musculus)
APP(672-711) [extracellular region] (Mus musculus)
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 signaling (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-711) [extracellular region] (Mus musculus)
Innate Immune System (Mus musculus)
Advanced glycosylation endproduct receptor signaling (Mus musculus)
Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-711) [extracellular region] (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-711) [extracellular region] (Mus musculus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Mus musculus)
TRAF6 mediated NF-kB activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-711) [extracellular region] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-711) [extracellular region] (Mus musculus)
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-711) [extracellular region] (Mus musculus)
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-711) [extracellular region] (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-711) [extracellular region] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-711) [extracellular region] (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-711) [extracellular region] (Mus musculus)
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-711) [extracellular region] (Mus musculus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-711) [extracellular region] (Mus musculus)
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)
AGER ligands:AGER [plasma membrane] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
APP(672-711) [extracellular region] (Mus musculus)
External Reference Information
External Reference
UniProt:P12023
Reference Genes
BioGPS Gene:11820 APP
ENSEMBL:ENSMUSG00000022892
KEGG:mmu:11820 APP
Monarch:11820 APP
NCBI Gene:11820 APP
UCSC:P12023 APP
Reference Transcript
RefSeq:NM_001198823.1 APP
Participates
as a member of
APP(672-713), APP(672-711) [extracellular region] (Mus musculus)
AGER ligands [extracellular region] (Mus musculus)
Other forms of this molecule
APP(672-713) [extracellular region]
APP(18-770) [platelet alpha granule lumen]
APP(18-770) [extracellular region]
APP [endoplasmic reticulum lumen]
phospho-p-APP [endoplasmic reticulum lumen]
APP(18-770) [endosome lumen]
APP [mitochondrial inner membrane]
APP (535-695) [cytosol]
APP-C99 [cytosol]
APP(18-770) [trans-Golgi network membrane]
Inferred From
APP(672-711) [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_001185752.1
ENSEMBL
ENSMUST00000227723
,
ENSMUSG00000022892
,
ENSMUSP00000005406
,
ENSMUSP00000154061
,
ENSMUST00000005406
PRO
P12023
MGI
88059
GlyGen
P12023
PDB
2YT0
,
5MYK
,
7MRN
,
8S4Y
,
2YSZ
,
4YN0
,
2ROZ
,
8BG9
,
2YT1
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P97318
2
phospho-Dab1 [cytosol]
(R-MMU-8855227)
Dab1 [cytosol]
(R-MMU-8855236)
0.704
3
UniProt:Q03157 APLP1
0.667
4
UniProt:P14211 Calr
8
Calreticulin [extracellular region]
(R-MMU-3221763)
CALR [endocytic vesicle lumen]
(R-MMU-2239448)
CALR [extracellular region]
(R-MMU-2197641)
CALR [endoplasmic reticulum lumen]
(R-MMU-195905)
Calreticulin [phagocytic vesicle]
(R-MMU-1236838)
CALR [phagocytic vesicle membrane]
(R-MMU-1236879)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-MMU-8863866)
CALR [lumenal side of endoplasmic reticulum membrane]
(R-MMU-985502)
0.621
4
UniProt:Q9WVI9 JIP1
0.621
3
UniProt:Q06335
4
APLP2 [plasma membrane]
(R-MMU-8848902)
APLP2 [platelet alpha granule membrane]
(R-MMU-8848898)
phospho-p-APLP2 [endoplasmic reticulum lumen]
(R-MMU-8956977)
APLP2 [endoplasmic reticulum lumen]
(R-MMU-8956784)
0.609
3
UniProt:Q9EPL2 CSTN1
0.602
3
UniProt:Q9WVI9-1 MAPK8IP1
0.576
3
UniProt:P98084 APBA2
0.564
2
UniProt:O88307 SORL
0.557
3
UniProt:Q6PHU5
2
Sort1 [Golgi membrane]
(R-MMU-434332)
Sort1 [cytoplasmic vesicle membrane]
(R-MMU-434221)
0.518
3
UniProt:Q9QXJ1
1
Apbb1 [nucleoplasm]
(R-MMU-5683987)
0.508
2
UniProt:Q9UQF2 JIP1
0.508
2
UniProt:Q62108 Dlg4
3
SAP-90 [plasma membrane]
(R-MMU-443606)
Dlg4 [endocytic vesicle membrane]
(R-MMU-416847)
Dlg4 [cytosol]
(R-MMU-6794267)
0.499
4
UniProt:Q9QZS3 Numb
2
Numb [plasma membrane]
(R-MMU-2077469)
Numb [plasma membrane]
(R-MMU-443595)
0.471
2
UniProt:Q61477 NBL1
0.471
2
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