Reactome | STO1 [cytosol]

STO1 [cytosol]

Stable Identifier

R-SCE-162459

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

NCBP1, P34160

Locations in the PathwayBrowser

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Metabolism of RNA (Saccharomyces cerevisiae)

- Nonsense-Mediated Decay (NMD) (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Saccharomyces cerevisiae)
      - Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        STO1 [cytosol] (Saccharomyces cerevisiae)
      - mRNA Cleaved by SMG6 [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        STO1 [cytosol] (Saccharomyces cerevisiae)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        STO1 [cytosol] (Saccharomyces cerevisiae)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        STO1 [cytosol] (Saccharomyces cerevisiae)
    - SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        STO1 [cytosol] (Saccharomyces cerevisiae)
      - mRNA Cleaved by SMG6 [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        STO1 [cytosol] (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Saccharomyces cerevisiae)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        STO1 [cytosol] (Saccharomyces cerevisiae)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        STO1 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P34160

Gene Names

STO1

Reference Genes

BioGPS Gene:855155 STO1

ENSEMBL:YMR125W

KEGG:sce:YMR125W STO1

Monarch:855155 STO1

NCBI Gene:855155 STO1

SGD:YMR125W

UCSC:P34160 STO1

Reference Transcript

RefSeq:NM_001182626.1 STO1

Other Identifiers

855155

GO:0000184

GO:0000243

GO:0000339

GO:0000398

GO:0000956

GO:0003723

GO:0003729

GO:0005515

GO:0005575

GO:0005634

GO:0005737

GO:0005844

GO:0005845

GO:0005846

GO:0006366

GO:0006370

GO:0006397

GO:0006401

GO:0006406

GO:0006970

GO:0008150

GO:0008380

GO:0015931

GO:0016070

GO:0031053

GO:0031124

GO:0042789

GO:0045292

GO:0048471

GO:0051028

GO:0051169

Participates

as a component of

Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)

Other forms of this molecule

STO1 [nucleoplasm]

Inferred From

NCBP1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_013844.2

ENSEMBL

YMR125W_mRNA, YMR125W, YMR125W

PRO

P34160

PDB

3UKY, 6N7P

Interactors (51)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08920	2	CBC2 [cytosol] (R-SCE-162458) CBC2 [nucleoplasm] (R-SCE-51463)	0.897	28
UniProt:Q02821	2	SRP1 [cytosol] (R-SCE-180612) SRP1 [cytosol] (R-SCE-9734672)	0.814	14
UniProt:Q05900	1	YHC1 [nucleoplasm] (R-SCE-8865876)	0.744	8
UniProt:P36036 YRA2			0.744	8
UniProt:P07260	1	CDC33 [cytosol] (R-SCE-72578)	0.643	3
UniProt:P53617	2	phospho-NRD1 [nucleoplasm] (R-SCE-8849461) NRD1 [nucleoplasm] (R-SCE-3900138)	0.643	5
UniProt:P32605	1	MUD1 [nucleoplasm] (R-SCE-71915)	0.643	5
UniProt:Q00539 NAM8			0.643	4
UniProt:P33334	1	PRP8 [nucleoplasm] (R-SCE-83810)	0.643	3
UniProt:P43321	2	SMD3 [cytosol] (R-SCE-191781) SMD3 [nucleoplasm] (R-SCE-192219)	0.643	3
UniProt:P32639	1	BRR2 [nucleoplasm] (R-SCE-71885)	0.643	3
UniProt:P53207 SNU71			0.643	6
UniProt:P33203 PRP40			0.643	4
UniProt:P40018	2	SMB1 [cytosol] (R-SCE-191798) SMB1 [nucleoplasm] (R-SCE-192213)	0.643	4
UniProt:Q00916	1	SNP1 [nucleoplasm] (R-SCE-71913)	0.643	6
UniProt:Q02260	2	SMD1 [cytosol] (R-SCE-191890) SMD1 [nucleoplasm] (R-SCE-192215)	0.643	4
UniProt:P39936	2	phospho-TIF4632 [cytosol] (R-SCE-165762-2) TIF4632 [cytosol] (R-SCE-72584-2)	0.643	3
UniProt:Q03782 SNU56			0.643	4
UniProt:Q06217	2	SMD2 [cytosol] (R-SCE-191810) SMD2 [nucleoplasm] (R-SCE-71901)	0.643	4
UniProt:Q07508 LUC7			0.643	5
UniProt:Q12046 CWC2			0.643	3
UniProt:Q03776 PRP42			0.643	5
UniProt:Q12476 AIR2			0.592	4
UniProt:P38996	2	NAB3 [nucleoplasm] (R-SCE-4570543) NAB3 [nucleoplasm] (R-SCE-71933)	0.527	4
UniProt:Q03654 CEF1			0.527	2
UniProt:Q03772 CWC15			0.527	2
UniProt:P54999	2	SMX3 [cytosol] (R-SCE-191852) SMX3 [nucleoplasm] (R-SCE-71907)	0.527	2
UniProt:P38241 SLT11			0.527	2
UniProt:Q12417 PRP46			0.527	2
UniProt:P53552 THO2			0.527	2
UniProt:P04147	1	PAB1 [cytosol] (R-SCE-156803)	0.527	2
UniProt:Q06142	4	KAP95 [ficolin-1-rich granule lumen] (R-SCE-6800978) KAP95 [extracellular region] (R-SCE-6806306) KAP95 [specific granule lumen] (R-SCE-6799646) KAP95 [cytosol] (R-SCE-180733)	0.527	2
UniProt:P38199	2	HEK2 [nucleoplasm] (R-SCE-71919-2) HEK2 [nucleoplasm] (R-SCE-71921-2)	0.527	2
UniProt:P39682 PRP39			0.527	3
UniProt:P10080 SSBP1			0.527	3
UniProt:P53333 CWC22			0.527	2
UniProt:P49955 SF3B1			0.527	3
UniProt:P53854 CWC25			0.527	2
UniProt:P25567 SRO9			0.527	2
UniProt:P32523	1	PRP19 [nucleoplasm] (R-SCE-5420907)	0.527	3
UniProt:P32524 PRP21			0.527	3
UniProt:Q02554 CUS1			0.527	3
UniProt:P28320 YJU2			0.527	2
UniProt:P36048	1	SNU114 [nucleoplasm] (R-SCE-71883)	0.527	2
UniProt:P10592	20	SSA2 [cytosol] (R-SCE-264476-3) SSA2 [nucleoplasm] (R-SCE-6792605) SSA2 [cytosol] (R-SCE-3371410-3) SSA2 [cytosol] (R-SCE-3371408-3) SSA2 [cytosol] (R-SCE-6792602) SSA2 [nucleoplasm] (R-SCE-5082380-3) SSA2 [secretory granule lumen] (R-SCE-6801472-3) SSA2 [secretory granule lumen] (R-SCE-6801530-3) SSA2 [extracellular region] (R-SCE-6805936-3) SSA2 [extracellular region] (R-SCE-6806500-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801496) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494-3) SSA2 [extracellular region] (R-SCE-6805872) SSA2 [nucleoplasm] (R-SCE-912480-3) SSA2 [nucleoplasm] (R-SCE-5082367-3) SSA2 [nucleoplasm] (R-SCE-5252082-3) SSA2 [nucleoplasm] (R-SCE-5252088-3) SSA2 [nucleoplasm] (R-SCE-5252009-3) SSA2 [nucleoplasm] (R-SCE-5252047-3)	0.527	2
UniProt:P21374	1	ISY1 [nucleoplasm] (R-SCE-6781963)	0.527	2
UniProt:Q12309 CLF1			0.527	2
UniProt:P28004 PRP45			0.527	2
UniProt:Q04693 RSE1			0.527	3
UniProt:Q04048	1	SYF1 [nucleoplasm] (R-SCE-67411)	0.527	2
UniProt:P19736 PRP9			0.527	2