Reactome | NCBP2 [cytosol]

NCBP2 [cytosol]

Stable Identifier

R-SCE-162458

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

Q08920

Locations in the PathwayBrowser

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Metabolism of RNA (Saccharomyces cerevisiae)

- Nonsense-Mediated Decay (NMD) (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Saccharomyces cerevisiae)
      - Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        NCBP2 [cytosol] (Saccharomyces cerevisiae)
      - mRNA Cleaved by SMG6 [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        NCBP2 [cytosol] (Saccharomyces cerevisiae)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        NCBP2 [cytosol] (Saccharomyces cerevisiae)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        NCBP2 [cytosol] (Saccharomyces cerevisiae)
    - SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        NCBP2 [cytosol] (Saccharomyces cerevisiae)
      - mRNA Cleaved by SMG6 [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        NCBP2 [cytosol] (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Saccharomyces cerevisiae)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        NCBP2 [cytosol] (Saccharomyces cerevisiae)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        NCBP2 [cytosol] (Saccharomyces cerevisiae)
- Processing of Capped Intron-Containing Pre-mRNA (Saccharomyces cerevisiae)
  - Transport of Mature Transcript to Cytoplasm (Saccharomyces cerevisiae)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Saccharomyces cerevisiae)
      - Transport of the export-competent mRNP complex through the NPC (Saccharomyces cerevisiae)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        NCBP2 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:Q08920

Reference Genes

BioGPS Gene:855925

ENSEMBL:YPL178W

KEGG:sce:YPL178W

Monarch:855925

NCBI Gene:855925

SGD:YPL178W

UCSC:Q08920

Reference Transcript

RefSeq:NM_001183992.1

Other Identifiers

1770708_at

7937_at

855925

GO:0000184

GO:0000243

GO:0000339

GO:0000398

GO:0000956

GO:0003674

GO:0003676

GO:0003723

GO:0005515

GO:0005575

GO:0005634

GO:0005737

GO:0005845

GO:0005846

GO:0006366

GO:0006397

GO:0006401

GO:0006406

GO:0006970

GO:0008150

GO:0008380

GO:0015931

GO:0031053

GO:0031124

GO:0042789

GO:0045292

GO:0048471

GO:0051028

GO:0051169

Participates

as a component of

Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)

Other forms of this molecule

NCBP2 [nucleoplasm]

Inferred From

NCBP2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_015147.1

ENSEMBL

YPL178W, YPL178W_mRNA, YPL178W

PRO

Q08920

PDB

6N7P

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P34160	2	STO1 [cytosol] (R-SCE-162459) STO1 [nucleoplasm] (R-SCE-51469)	0.861	26
UniProt:Q02821	2	SRP1 [cytosol] (R-SCE-180612) SRP1 [cytosol] (R-SCE-9734672)	0.771	11
UniProt:P53617 NRD1			0.725	4
UniProt:Q06142	4	KAP95 [specific granule lumen] (R-SCE-6799646) KAP95 [extracellular region] (R-SCE-6806306) KAP95 [ficolin-1-rich granule lumen] (R-SCE-6800978) KAP95 [cytosol] (R-SCE-180733)	0.669	6
UniProt:Q07508 LUC7			0.643	3
UniProt:Q00539 NAM8			0.643	4
UniProt:Q06217	2	SMD2 [cytosol] (R-SCE-191810) SMD2 [nucleoplasm] (R-SCE-71901)	0.643	3
UniProt:Q03782 SNU56			0.643	3
UniProt:P39936 IF4F2			0.643	3
UniProt:P36036 YRA2			0.589	3
UniProt:P40018	2	SMB1 [cytosol] (R-SCE-191798) SMB1 [nucleoplasm] (R-SCE-192213)	0.527	2
UniProt:P38996	2	NAB3 [nucleoplasm] (R-SCE-4570543) NAB3 [nucleoplasm] (R-SCE-71933)	0.527	3
UniProt:Q03735 NAB6			0.527	2
UniProt:P33334 PRP8			0.527	2
UniProt:P10591	17	SSA1 [cytosol] (R-SCE-3371410-2) SSA1 [cytosol] (R-SCE-3371408-2) SSA1 [cytosol] (R-SCE-6792602-2) SSA1 [ficolin-1-rich granule lumen] (R-SCE-6801512-2) SSA1 [ficolin-1-rich granule lumen] (R-SCE-6801496-2) SSA1 [extracellular region] (R-SCE-6805872-2) SSA1 [extracellular region] (R-SCE-6806500-2) SSA1 [secretory granule lumen] (R-SCE-6801472-2) SSA1 [nucleoplasm] (R-SCE-6792605-2) SSA1 [nucleoplasm] (R-SCE-912480-2) SSA1 [nucleoplasm] (R-SCE-5082367-2) SSA1 [nucleoplasm] (R-SCE-5252082-2) SSA1 [nucleoplasm] (R-SCE-5252088-2) SSA1 [nucleoplasm] (R-SCE-5252009-2) SSA1 [cytosol] (R-SCE-5251948-2) SSA1 [cytosol] (R-SCE-5251981-2) SSA1 [cytosol] (R-SCE-3371521-2)	0.527	2
UniProt:P11484	17	HSPA1L [cytosol] (R-SCE-3371410-4) HSPA2 [cytosol] (R-SCE-3371408-4) HSPA1A [cytosol] (R-SCE-6792602-4) HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-4) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-4) HSPA1A [extracellular region] (R-SCE-6805872-4) HSPA6 [extracellular region] (R-SCE-6806500-4) HSPA6 [secretory granule lumen] (R-SCE-6801472-4) HSPA1A [nucleoplasm] (R-SCE-6792605-4) HSPA2 [nucleoplasm] (R-SCE-912480-4) HSPA1L [nucleoplasm] (R-SCE-5082367-4) HSPA14 [nucleoplasm] (R-SCE-5252082-4) HSPA6 [nucleoplasm] (R-SCE-5252088-4) HSPA13 [nucleoplasm] (R-SCE-5252009-4) HSPA14 [cytosol] (R-SCE-5251948-4) HSPA13 [cytosol] (R-SCE-5251981-4) HSPA6 [cytosol] (R-SCE-3371521-4)	0.527	2
UniProt:Q01560 NOP3			0.527	2
UniProt:P32605	1	MUD1 [nucleoplasm] (R-SCE-71915)	0.527	2
UniProt:P53207 SNU71			0.527	3
UniProt:Q04693 RSE1			0.527	2
UniProt:Q00916	1	SNP1 [nucleoplasm] (R-SCE-71913)	0.527	2