Reactome | CBC2 [cytosol]

CBC2 [cytosol]

Stable Identifier

R-SCE-162458

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

NCBP2, Q08920

Locations in the PathwayBrowser

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Metabolism of RNA (Saccharomyces cerevisiae)

- Nonsense-Mediated Decay (NMD) (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        CBC2 [cytosol] (Saccharomyces cerevisiae)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        CBC2 [cytosol] (Saccharomyces cerevisiae)
    - SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        CBC2 [cytosol] (Saccharomyces cerevisiae)
      - mRNA Cleaved by SMG6 [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        CBC2 [cytosol] (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Saccharomyces cerevisiae)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        CBC2 [cytosol] (Saccharomyces cerevisiae)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        CBC2 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:Q08920

Gene Names

CBC2

Reference Genes

BioGPS Gene:855925 CBC2

ENSEMBL:YPL178W

KEGG Gene (Saccharomyces cerevisiae (strain YJM789)):YPL178W CBC2

Monarch:855925 CBC2

NCBI Gene:855925 CBC2

SGD:YPL178W

Reference Transcript

RefSeq:NM_001183992.1 CBC2

Other Identifiers

1770708_at

7937_at

855925

GO:0000184

GO:0000243

GO:0000339

GO:0000398

GO:0003674

GO:0003676

GO:0003723

GO:0005575

GO:0005634

GO:0005737

GO:0005846

GO:0006397

GO:0006401

GO:0008150

GO:0008380

GO:0015931

GO:0045292

GO:0048471

GO:0051028

Participates

as a component of

Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)

Other forms of this molecule

CBC2 [nucleoplasm]

Inferred From

NCBP2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_015147.1

PRO

Q08920

PDB

6N7P

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P34160	2	STO1 [cytosol] (R-SCE-162459) STO1 [nucleoplasm] (R-SCE-51469)	0.818	25
UniProt:Q02821	2	SRP1 [cytosol] (R-SCE-205976) SRP1 [cytosol] (R-SCE-180612)	0.771	11
UniProt:Q06142	4	KAP95 [extracellular region] (R-SCE-6806306) KAP95 [ficolin-1-rich granule lumen] (R-SCE-6800978) KAP95 [specific granule lumen] (R-SCE-6799646) KAP95 [cytosol] (R-SCE-180733)	0.669	6
UniProt:P53617	2	NRD1 [nucleoplasm] (R-SCE-3900138) phospho-NRD1 [nucleoplasm] (R-SCE-8849461)	0.643	3
UniProt:Q03735 NAB6			0.527	2
UniProt:P10591	2	SSA1 [nucleoplasm] (R-SCE-912480-2) SSA1 [cytosol] (R-SCE-3371408-2)	0.527	2
UniProt:Q07508 LUC7			0.527	2
UniProt:Q00539 NAM8			0.527	3
UniProt:P11484 SSB1			0.527	2
UniProt:Q06217	1	SMD2 [cytosol] (R-SCE-191810)	0.527	2
UniProt:Q01560 NOP3			0.527	2
UniProt:Q03782 SNU56			0.527	2
UniProt:P39936	2	TIF4632 [cytosol] (R-SCE-72584-2) phospho-TIF4632 [cytosol] (R-SCE-165762-2)	0.527	2
UniProt:P53207 SNU71			0.527	3
UniProt:Q04693 RSE1			0.527	2
UniProt:Q00916 RU17			0.527	2
UniProt:P38996	2	NAB3 [nucleoplasm] (R-SCE-71933) NAB3 [nucleoplasm] (R-SCE-4570543)	0.527	3