Reactome | GCLM [cytosol]

GCLM [cytosol]

Stable Identifier

R-HSA-174356

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Glutamate--cysteine ligase light chain, gamma-glutamylcysteine light chain

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        NFE2L2 regulating anti-oxidant/detoxification enzymes (Homo sapiens)
        
        AcK-NFE2L2-dependent GCLM gene expression (Homo sapiens)
        
        GCLM [cytosol] (Homo sapiens)

Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase II - Conjugation of compounds (Homo sapiens)
    - Glutathione conjugation (Homo sapiens)
      - Glutathione synthesis and recycling (Homo sapiens)
        
        GCL ligates L-Glu to L-Cys (Homo sapiens)
        
        GCL [cytosol] (Homo sapiens)
        
        GCLM [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48507 GCLM

Gene Names

GCLM, GLCLR

Chain

chain:1-274

Reference Genes

BioGPS Gene:2730 GCLM

COSMIC (genes):GCLM GCLM

CTD Gene:2730 GCLM

dbSNP Gene:2730 GCLM

ENSEMBL:ENSG00000023909 GCLM

ENSEMBL_homo_sapiens_GENE:ENSG00000023909.10 GCLM

HGNC:4312 GCLM

KEGG Gene (Homo sapiens):2730 GCLM

Monarch:2730 GCLM

NCBI Gene:2730 GCLM

OMIM:601176 GCLM

UCSC:P48507 GCLM

Reference Transcript

Other Identifiers

11723489_at

11723490_at

16689752

203925_PM_at

203925_at

234986_PM_at

234986_at

236140_PM_at

236140_at

2423620

2423622

2423623

2423624

2423626

2423627

2423628

2423629

2423632

2423635

2423636

2423638

2423641

2423643

2423644

2423645

2423646

2730

33163_r_at

55923_at

7917779

90801_at

A_23_P103996

A_32_P177953

A_33_P3265606

GE57736

GO:0003013

GO:0003824

GO:0004357

GO:0005515

GO:0005829

GO:0006520

GO:0006534

GO:0006536

GO:0006575

GO:0006749

GO:0006750

GO:0006790

GO:0006979

GO:0007005

GO:0007584

GO:0008637

GO:0009410

GO:0012501

GO:0014823

GO:0016874

GO:0017109

GO:0023052

GO:0030234

GO:0035226

GO:0035729

GO:0035733

GO:0043524

GO:0044344

GO:0044752

GO:0044877

GO:0051409

GO:0051900

GO:0071333

GO:0071372

GO:0097069

GO:0097746

GO:0098772

GO:1990830

GO:2001237

HMNXSV003030344

Hs.193452.0.A1_3p_at

Hs.315562.0.A1_3p_at

ILMN_1788547

ILMN_2225974

L35546_at

PH_hs_0023764

TC01002882.hg

g4504010_3p_at

Participates

as a component of

as an output of

AcK-NFE2L2-dependent GCLM gene expression (Homo sapiens)

Inferred To

gclm [cytosol] (Xenopus tropicalis)

GCLM [cytosol] (Bos taurus)

GCLM [cytosol] (Caenorhabditis elegans)

GCLM [cytosol] (Canis familiaris)

GCLM [cytosol] (Schizosaccharomyces pombe)

GCLM [cytosol] (Sus scrofa)

Gclm [cytosol] (Drosophila melanogaster)

Gclm [cytosol] (Mus musculus)

Gclm [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001295182.1, NP_002052.1

OpenTargets

ENSG00000023909

HPA

ENSG00000023909-GCLM

GeneCards

P48507

Ensembl

ENSP00000484507, ENST00000615724, ENST00000370238, ENSP00000359258, ENSG00000023909

PRO

P48507

Pharos - Targets

P48507

HMDB Protein

HMDBP00513

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48506 GCLC	4	GCLC H370L [cytosol] (R-HSA-5602842) GCLC P185L [cytosol] (R-HSA-5602975) GCLC R127C [cytosol] (R-HSA-5602822) GCLC [cytosol] (R-HSA-174385)	0.59	2
UniProt:Q9UJX0 OSGI1			0.556	3