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SPHK1 [cytosol]
Stable Identifier
R-HSA-391267
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Sphingosine kinase 1
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Sphingolipid de novo biosynthesis (Homo sapiens)
SPHK1 phosphorylates sphingoid (Homo sapiens)
SPHK1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Association of TriC/CCT with target proteins during biosynthesis (Homo sapiens)
Association of CCT/TriC with sphingosine kinase 1 (Homo sapiens)
CCT/TRiC:ADP:Sphingosine kinase 1 [cytosol] (Homo sapiens)
SPHK1 [cytosol] (Homo sapiens)
SPHK1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
SPHK1 phosphorylates sphingosine in response to E2 stimulation (Homo sapiens)
SPHK1 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated cell proliferation (Homo sapiens)
PKC phosphorylates sphingosine kinase 1 (Homo sapiens)
SPHK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NYA1 SPHK1
Gene Names
SPHK1, SK1, SPHK, SPK
Chain
chain:1-384
Reference Genes
COSMIC (genes):SPHK1 SPHK1
dbSNP Gene:8877 SPHK1
ENSEMBL:ENSG00000176170 SPHK1
Participates
as a component of
CCT/TRiC:ADP:Sphingosine kinase 1 [cytosol] (Homo sapiens)
as an input of
Association of CCT/TriC with sphingosine kinase 1 (Homo sapiens)
PKC phosphorylates sphingosine kinase 1 (Homo sapiens)
Other forms of this molecule
SPHK1 [nucleoplasm]
p-S225-SPHK1 [nucleoplasm]
p-S225-SPHK1 [cytosol]
Inferred To
SPHK1 [cytosol]
(Bos taurus)
SPHK1 [cytosol]
(Caenorhabditis elegans)
SPHK1 [cytosol]
(Canis familiaris)
SPHK1 [cytosol]
(Dictyostelium discoideum)
SPHK1 [cytosol]
(Gallus gallus)
SPHK1 [cytosol]
(Mus musculus)
SPHK1 [cytosol]
(Rattus norvegicus)
SPHK1 [cytosol]
(Saccharomyces cerevisiae)
SPHK1 [cytosol]
(Schizosaccharomyces pombe)
SPHK1 [cytosol]
(Sus scrofa)
Sk1 [cytosol]
(Drosophila melanogaster)
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q2M3C7 SPKAP
0.602
4
UniProt:P68104 EEF1A1
7
EEF1A1 [lysosomal membrane]
(R-HSA-9626022)
EEF1A1 [cytosol]
(R-HSA-156905)
EEF1A1 [secretory granule lumen]
(R-HSA-6801479)
EEF1A1 [extracellular region]
(R-HSA-6806456)
EEF1A1 [ficolin-1-rich granule lumen]
(R-HSA-6801528)
Me3K318-EEF1A1 [cytosol]
(R-HSA-8932419)
Me3K79-EEF1A1 [cytosol]
(R-HSA-8932212)
0.544
2
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.543
7
UniProt:Q96PQ7 KLHL5
1
KLHL5 [cytosol]
(R-HSA-8863223)
0.482
2
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