Reactome | SYVN1(1-617) [endoplasmic reticulum membrane]

SYVN1(1-617) [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-535496

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

SYVN1, E3 ubiquitin-protein ligase synoviolin, SYVN1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q86TM6 SYVN1

Gene Names

SYVN1, HRD1, KIAA1810

Chain

chain:1-617

Reference Genes

BioGPS Gene:84447 SYVN1

COSMIC (genes):SYVN1 SYVN1

CTD Gene:84447 SYVN1

dbSNP Gene:84447 SYVN1

ENSEMBL:ENSG00000162298 SYVN1

HGNC:20738 SYVN1

KEGG:hsa:84447 SYVN1

Monarch:84447 SYVN1

NCBI Gene:84447 SYVN1

OMIM:608046 SYVN1

UCSC:Q86TM6 SYVN1

Reference Transcript

Other Identifiers

11716172_at

11718595_a_at

11753927_x_at

11758745_at

16740326

16740342

18671377

18671378

18671379

18671380

18671381

18671382

18671383

18671387

200019_PM_s_at

200019_s_at

225090_PM_at

225090_at

31955_at

3377464

3377465

3377466

3377467

3377468

3377469

3377470

3377471

3377473

3377475

3377476

3377477

3377478

3377479

3377480

3377481

3377482

3377483

3377484

3377485

3377486

3377487

3377488

3377489

3377490

3377491

3377492

3377493

3377494

3377495

3377496

3377497

3377498

3377499

3377500

3377501

3377502

3377503

3377504

3377505

3377506

3813355

78756_at

7893603

7894699

7894758

7896431

7896621

7949377

7949383

84447

A_23_P138826

A_24_P381224

GE79795

GO:0000836

GO:0000839

GO:0002327

GO:0002376

GO:0003824

GO:0005515

GO:0005654

GO:0005737

GO:0005783

GO:0005789

GO:0005790

GO:0006511

GO:0006886

GO:0012505

GO:0016020

GO:0016567

GO:0016740

GO:0030154

GO:0030163

GO:0030970

GO:0036503

GO:0036513

GO:0043161

GO:0043226

GO:0044322

GO:0046872

GO:0050821

GO:0051082

GO:0051087

GO:0051117

GO:0061630

GO:0070936

GO:0140096

GO:1901135

GO:1902236

GO:1904380

GO:1990381

HMNXSV003028239

HMNXSV003040770

HMNXSV003049932

Hs.75859.1.A1_3p_at

ILMN_1803143

ILMN_2339691

PH_hs_0023795

PH_hs_0032654

TC11001928.hg

TC11001929.hg

g4503658_3p_a_at

Participates

as a component of

SYVN1 dimer [endoplasmic reticulum membrane] (Homo sapiens)

as an output of

Expression of SYVN1 (HRD1) (Homo sapiens)

as a member of

ERAD E3 ligases [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

sel-11 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

sip3 [endoplasmic reticulum membrane] (Drosophila melanogaster)

Syvn1 [endoplasmic reticulum membrane] (Rattus norvegicus)

SYVN1 [endoplasmic reticulum membrane] (Bos taurus)

SYVN1 [endoplasmic reticulum membrane] (Canis familiaris)

SYVN1 [endoplasmic reticulum membrane] (Sus scrofa)

SYVN1(1-617) [endoplasmic reticulum membrane] (Danio rerio)

SYVN1(1-617) [endoplasmic reticulum membrane] (Dictyostelium discoideum)

SYVN1(1-617) [endoplasmic reticulum membrane] (Mus musculus)

syvn1 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Ghost homologue of SYVN1(1-617) [endoplasmic reticulum membrane] (Gallus gallus)

hrd1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

Cross References

ENSEMBL

ENSP00000366395, ENST00000377190, ENSP00000294256, ENSP00000436984, ENST00000526060, ENSP00000302035, ENST00000307289, ENST00000294256

OpenTargets

ENSG00000162298

HPA

ENSG00000162298-SYVN1

PRO

Q86TM6

Pharos - Targets

Q86TM6

GlyGen

Q86TM6

HMDB Protein

HMDBP09317

PDB

6A3Z

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UBU6 FA8A1			0.79	22
UniProt:Q9UBV2 SEL1L	1	SEL1L [endoplasmic reticulum membrane] (R-HSA-1911545)	0.773	21
UniProt:Q9Y385 UBE2J1	1	UBE2J1 [cytosol] (R-HSA-947625)	0.702	15
UniProt:Q13438 OS9	1	OS9 [endoplasmic reticulum membrane] (R-HSA-1022132)	0.69	10
UniProt:Q9Y4E8 USP25	1	USP15 [cytosol] (R-HSA-2173138)	0.668	8
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.61	5
UniProt:Q9Y679 AUP1			0.597	8
UniProt:O75477 ERLIN1	1	ERLIN1 [endoplasmic reticulum membrane] (R-HSA-8866518)	0.564	2
UniProt:O94905 ERLIN2	3	EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-FGFR1(1-822) [plasma membrane] (R-HSA-8853148) EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-p-8Y-FGFR1(1-822) [plasma membrane] (R-HSA-8853122) ERLIN2 [endoplasmic reticulum membrane] (R-HSA-8866520)	0.564	2
UniProt:O75460 ERN1	2	p-S724-ERN1 [endoplasmic reticulum membrane] (R-HSA-381029) ERN1 [endoplasmic reticulum membrane] (R-HSA-381076)	0.524	2
UniProt:O75460-1 ERN1			0.499	3
UniProt:P55072 VCP	8	VCP [cytosol] (R-HSA-1181251) VCP [secretory granule lumen] (R-HSA-6801039) VCP [extracellular region] (R-HSA-6806191) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [nucleoplasm] (R-HSA-5643745) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209)	0.462	2
UniProt:Q15011 HERPUD1	1	HERPUD1 [endoplasmic reticulum membrane] (R-HSA-535608)	0.462	10