Reactome | GNA12 [plasma membrane]

GNA12 [plasma membrane]

Stable Identifier

R-HSA-55355

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

G protein alpha 12, Guanine nucleotide-binding protein, alpha-12 subunit, G alpha 12

Locations in the PathwayBrowser

Expand all

Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Thrombin signalling through proteinase activated receptors (PARs) (Homo sapiens)
    - Thrombin-activated PARs activate G12/13 (Homo sapiens)
      - Thrombin activated PAR:G12/13 (active) [plasma membrane] (Homo sapiens)
        
        G-protein G12/G13 (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein G12 (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (12):GTP [plasma membrane] (Homo sapiens)
        
        GNA12 [plasma membrane] (Homo sapiens)
      - Thrombin activated PAR:G12/13 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein G12/G13 (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein G12 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (12):GDP [plasma membrane] (Homo sapiens)
        
        GNA12 [plasma membrane] (Homo sapiens)
    - Thrombin-activated PARs binds G-protein G12/13 (Homo sapiens)
      - G-protein G12/G13 (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein G12 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (12):GDP [plasma membrane] (Homo sapiens)
        
        GNA12 [plasma membrane] (Homo sapiens)
      - Thrombin activated PAR:G12/13 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein G12/G13 (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein G12 (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (12):GDP [plasma membrane] (Homo sapiens)
        
        GNA12 [plasma membrane] (Homo sapiens)
    - Thrombin-activated PARs:G12/13 (active) dissociate (Homo sapiens)
      - G-protein alpha (12/13):GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (12):GTP [plasma membrane] (Homo sapiens)
        
        GNA12 [plasma membrane] (Homo sapiens)
      - Thrombin activated PAR:G12/13 (active) [plasma membrane] (Homo sapiens)
        
        G-protein G12/G13 (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein G12 (active) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (12):GTP [plasma membrane] (Homo sapiens)
        
        GNA12 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q03113 GNA12

Gene Names

GNA12

Chain

chain:1-381

Reference Genes

BioGPS Gene:2768 GNA12

COSMIC - genes:GNA12 GNA12

CTD Gene:2768 GNA12

dbSNP Gene:2768 GNA12

ENSEMBL:ENSG00000146535 GNA12

HGNC:4380 GNA12

KEGG:hsa:2768 GNA12

Monarch:2768 GNA12

NCBI Gene:2768 GNA12

OMIM:604394 GNA12

UCSC:Q03113 GNA12

Reference Transcript

Other Identifiers

11727847_a_at

11727848_a_at

11751417_a_at

17054611

221737_PM_at

221737_at

224681_PM_at

224681_at

231296_PM_at

231296_at

2768

3035902

3035903

3035904

3035905

3035906

3035908

3035909

3035910

3035911

3035912

3035913

3035914

3035915

3035916

3035917

3035918

3035919

3035920

3035921

3035922

3035930

3035931

3035933

3035934

3035935

3035936

3035937

3035944

3035945

3035946

3035951

3035952

3035963

3035964

3035965

3035966

34106_at

57079_at

8137865

919_at

A_21_P0005594

A_23_P215265

A_23_P354270

A_24_P98086

GO:0000166

GO:0001664

GO:0001701

GO:0003924

GO:0003925

GO:0005515

GO:0005525

GO:0005737

GO:0005834

GO:0005886

GO:0005925

GO:0007165

GO:0007186

GO:0007188

GO:0007266

GO:0007596

GO:0008217

GO:0008360

GO:0009410

GO:0010762

GO:0016020

GO:0016328

GO:0016787

GO:0019001

GO:0030154

GO:0031526

GO:0031683

GO:0031752

GO:0032006

GO:0032434

GO:0035556

GO:0042733

GO:0043005

GO:0043025

GO:0046872

GO:0048856

GO:0051721

GO:0072542

GO:0098772

GO:0160221

GO:1904706

GO:1904753

HMNXSV003022704

HMNXSV003029799

Hs.182874.1.S2_3p_at

Hs.182874.1.S3_3p_at

ILMN_1692191

ILMN_1699358

ILMN_2216157

PH_hs_0010791

TC07002754.hg

TC07002755.hg

p23607

Participates

as a component of

Inferred To

GNA12 [plasma membrane] (Bos taurus)

GNA12 [plasma membrane] (Caenorhabditis elegans)

GNA12 [plasma membrane] (Canis familiaris)

GNA12 [plasma membrane] (Danio rerio)

GNA12 [plasma membrane] (Dictyostelium discoideum)

GNA12 [plasma membrane] (Drosophila melanogaster)

GNA12 [plasma membrane] (Gallus gallus)

GNA12 [plasma membrane] (Mus musculus)

GNA12 [plasma membrane] (Rattus norvegicus)

GNA12 [plasma membrane] (Sus scrofa)

Homologues of GNA12 [plasma membrane] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001269370.1, NP_001280021.1, NP_031379.2

ENSEMBL

ENST00000407904, ENSP00000275364, ENSP00000385935, ENST00000715274, ENST00000275364, ENSP00000520443, ENSG00000146535

OpenTargets

ENSG00000146535

GeneCards

GNA12

HPA

ENSG00000146535-GNA12

PRO

Q03113

Pharos - Targets

Q03113

HMDB Protein

HMDBP11484

PDB

7YDJ

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