Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors

Stable Identifier
R-HSA-5694431
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
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Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors
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Secretion of the clotting factor precursors Factor V and Factor VIII from the ER depends on interaction with a Ca2+-dependent receptor complex of LMAN1 and its soluble interaction partner MCFD2 (Nyfeler et al, 2006; reviewed in Zheng and Zhang, 2013; Dancourt and Barlowe, 2010).
Literature References
PubMed ID Title Journal Year
17010120 Cargo selectivity of the ERGIC-53/MCFD2 transport receptor complex

Kaufman, RJ, Hauri, HP, Ginsburg, D, Zhang, B, Nyfeler, B

Traffic 2006
20533886 Protein sorting receptors in the early secretory pathway

Dancourt, J, Barlowe, C

Annu. Rev. Biochem. 2010
23852824 Combined deficiency of coagulation factors V and VIII: an update

Zheng, C, Zhang, B

Semin. Thromb. Hemost. 2013
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Orthologous Events
Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Bos taurus)
Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Canis familiaris)
Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Gallus gallus)
Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Mus musculus)
Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Rattus norvegicus)
Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Sus scrofa)
Authored
Rothfels, K  (2015-04-18)
Reviewed
Gillespie, ME  (2015-08-18)
Created
Rothfels, K  (2015-05-21)
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