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POLN [nucleoplasm]
Stable Identifier
R-HSA-6786153
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA polymerase nu
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Fanconi Anemia Pathway (Homo sapiens)
POLN binds ICL-DNA (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Homo sapiens)
POLN [nucleoplasm] (Homo sapiens)
POLN [nucleoplasm] (Homo sapiens)
Translesion synthesis across unhooked ICL by POLN (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Homo sapiens)
POLN [nucleoplasm] (Homo sapiens)
POLN [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q7Z5Q5 POLN
Gene Names
POLN
Chain
chain:1-900
Reference Genes
BioGPS Gene:353497 POLN
COSMIC (genes):POLN POLN
CTD Gene:353497 POLN
dbSNP Gene:353497 POLN
ENSEMBL:ENSG00000130997 POLN
ENSEMBL_homo_sapiens_GENE:ENSG00000130997.16 POLN
HGNC:18870 POLN
KEGG Gene (Homo sapiens):353497 POLN
Monarch:353497 POLN
NCBI Gene:353497 POLN
OMIM:610887 POLN
UCSC:Q7Z5Q5 POLN
Reference Transcript
RefSeq:NM_181808.3 POLN
Other Identifiers
11737670_a_at
11752374_a_at
16973655
233454_PM_at
233454_at
2757626
2757627
2757628
2757633
2757634
2757642
2757649
2757651
2757653
2757655
2757666
2757668
2757669
2757670
2757676
2757678
2757680
2757686
2757687
2757688
2757690
2757692
2757693
2757694
2757696
2757697
2757698
2757699
2757700
2757701
2757703
2757739
2757740
2757744
353497
8098958
A_32_P414791
GO:0000724
GO:0003676
GO:0003677
GO:0003824
GO:0003887
GO:0005515
GO:0005634
GO:0005654
GO:0006260
GO:0006261
GO:0006281
GO:0006302
GO:0006310
GO:0006974
GO:0016740
GO:0016779
GO:0019985
GO:0030332
GO:0036297
GO:0043226
GO:0140097
HMNXSV003015472
Hs.283829.0.S1_3p_at
ILMN_1725166
PH_hs_0024069
Participates
as an output of
Translesion synthesis across unhooked ICL by POLN (Homo sapiens)
as a component of
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Homo sapiens)
as an input of
POLN binds ICL-DNA (Homo sapiens)
Inferred To
Poln [nucleoplasm]
(Mus musculus)
Poln [nucleoplasm]
(Rattus norvegicus)
POLN [nucleoplasm]
(Bos taurus)
POLN [nucleoplasm]
(Caenorhabditis elegans)
POLN [nucleoplasm]
(Canis familiaris)
POLN [nucleoplasm]
(Danio rerio)
POLN [nucleoplasm]
(Dictyostelium discoideum)
POLN [nucleoplasm]
(Drosophila melanogaster)
POLN [nucleoplasm]
(Plasmodium falciparum)
Ghost homologue of POLN [nucleoplasm]
(Gallus gallus)
HAUS3 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_861524.2
OpenTargets
ENSG00000130997
HPA
ENSG00000130997-POLN
GeneCards
Q7Z5Q5
Ensembl
ENST00000382865
,
ENST00000511885
,
ENSP00000372316
,
ENSP00000435506
,
ENSG00000130997
ZINC target
Q7Z5Q5
PRO
Q7Z5Q5
Pharos - Targets
Q7Z5Q5
PDB
4XVM
,
4XVI
,
4XVL
,
4XVK
HMDB Protein
HMDBP11717
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