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TXNRD1 [cytosol]
Stable Identifier
R-HSA-73531
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
thioredoxin reductase 1, Thioredoxin reductase, cytoplasmic precursor (EC 1.8.1.9) (TR), Thioredoxin reductase, cytoplasmic precursor , TR, TR1
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
TXNRD1 [cytosol] (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Homo sapiens)
AcK-NFE2L2-dependent TXNRD1 gene expression (Homo sapiens)
TXNRD1 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Uptake and actions of bacterial toxins (Homo sapiens)
Uptake and function of diphtheria toxin (Homo sapiens)
DT fragment B transports DT fragment A from target cell endosome membrane (Homo sapiens)
TXNRD1 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
TXNRD1 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Selenoamino acid metabolism (Homo sapiens)
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se (Homo sapiens)
SeO3(2-) is reduced to H2Se by TXNRD1 (Homo sapiens)
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
TXNRD1 [cytosol] (Homo sapiens)
Metabolism of ingested MeSeO2H into MeSeH (Homo sapiens)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Homo sapiens)
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
TXNRD1 [cytosol] (Homo sapiens)
MeSeOH is reduced to MeSeH by TXNRD1 (Homo sapiens)
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
TXNRD1 [cytosol] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of TXNRD1 (Homo sapiens)
TXNRD1 [cytosol] (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
TXNRD1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16881 TXNRD1
Gene Names
TXNRD1, GRIM12, KDRF
Chain
chain:1-649
Reference Genes
BioGPS Gene:7296 TXNRD1
COSMIC (genes):TXNRD1 TXNRD1
CTD Gene:7296 TXNRD1
dbSNP Gene:7296 TXNRD1
ENSEMBL:ENSG00000198431 TXNRD1
ENSEMBL_homo_sapiens_GENE:ENSG00000198431.18 TXNRD1
HGNC:12437 TXNRD1
KEGG Gene (Homo sapiens):7296 TXNRD1
Monarch:7296 TXNRD1
NCBI Gene:7296 TXNRD1
OMIM:601112 TXNRD1
UCSC:Q16881 TXNRD1
Reference Transcript
RefSeq:NM_001261446.1 TXNRD1
RefSeq:NM_182729.2 TXNRD1
RefSeq:NM_001261445.1 TXNRD1
RefSeq:NM_003330.3 TXNRD1
RefSeq:NM_001093771.2 TXNRD1
RefSeq:NM_182742.2 TXNRD1
RefSeq:NM_182743.2 TXNRD1
Other Identifiers
11715649_s_at
11715650_a_at
11750416_a_at
16756163
201266_PM_at
201266_at
3429463
3429467
3429469
3429475
3429476
3429477
3429481
3429483
3429485
3429490
3429491
3429492
3429493
3429494
3429495
3429496
3429497
3429498
3429500
3429501
3429502
3429504
3429505
3429506
3429508
3429509
3429512
3429518
3429519
3429520
3429521
3429550
39425_at
7296
7958174
A_14_P119962
A_14_P132701
A_23_P204581
A_33_P3351120
GE60139
GO:0000166
GO:0001650
GO:0001707
GO:0003824
GO:0004791
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005739
GO:0005829
GO:0006979
GO:0007165
GO:0007369
GO:0008283
GO:0010035
GO:0016209
GO:0016491
GO:0016668
GO:0023052
GO:0042802
GO:0043226
GO:0045454
GO:0048856
GO:0050137
GO:0050660
GO:0070062
GO:0071949
GO:0098754
GO:0098869
GO:0140096
HMNXSV003004085
ILMN_1717056
ILMN_2324421
PH_hs_0025324
TC12000810.hg
X91247_at
g4507746_3p_at
Participates
as an output of
Expression of TXNRD1 (Homo sapiens)
AcK-NFE2L2-dependent TXNRD1 gene expression (Homo sapiens)
as a component of
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
This entity regulates
Positively
DT fragment B transports DT fragment A from target cell endosome membrane
(Homo sapiens)
Inferred To
TXNRD1 [cytosol]
(Bos taurus)
TXNRD1 [cytosol]
(Caenorhabditis elegans)
TXNRD1 [cytosol]
(Gallus gallus)
TXNRD1 [cytosol]
(Mus musculus)
TXNRD1 [cytosol]
(Plasmodium falciparum)
TXNRD1 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_877419.1
,
NP_001248375.1
,
NP_877393.1
,
NP_001248374.1
,
NP_877420.1
,
NP_001087240.1
,
NP_003321.3
OpenTargets
ENSG00000198431
ZINC - Substances
TRXR1_HUMAN
ZINC target
Q16881
PRO
Q16881
PDB
2CFY
,
3QFA
,
7X1R
,
2ZZB
,
2J3N
,
2ZZC
,
2ZZ0
,
3QFB
IntEnz
1.8.1.9
GeneCards
Q16881
HPA
ENSG00000198431-TXNRD1
Ensembl
ENSP00000421934
,
ENST00000526390
,
ENSP00000435123
,
ENSG00000198431
,
ENST00000526950
,
ENST00000525566
,
ENST00000524698
,
ENST00000503506
,
ENST00000526691
,
ENSP00000435929
,
ENSP00000432812
,
ENST00000529546
,
ENSP00000433425
,
ENSP00000434516
,
ENSP00000434919
Pharos - Targets
Q16881
Orphanet
25012
HMDB Protein
HMDBP00134
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q03135 CAV1
5
CAV1 [Golgi membrane]
(R-HSA-204504)
CAV1 [plasma membrane]
(R-HSA-534994)
CAV1 [early endosome membrane]
(R-HSA-5368451)
CAV1 [lipid droplet]
(R-HSA-163510)
CAV1 [endocytic vesicle membrane]
(R-HSA-535009)
0.632
4
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