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Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
Stable Identifier
R-HSA-749456
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Many unrelated GPCRs couple with the Gi G-protein subtype. The G-alpha (i) subunit inhibits the production of cAMP from ATP. In turn, this results in decreased activity of cAMP-dependent protein kinase. There are 8 types of G-alpha (i) known to date:G(i)1, G(i)2, G(i)3, G(i)o, G(i)z, G(i)gust (gustducin) and two G(i)t (retinal transducin) (Downes GB and Gautam N, 1999). Once GDP is exchanged for GTP on the alpha subunit, it dissociates from the G-beta-gamma subunit.
Literature References
PubMed ID
Title
Journal
Year
2834384
Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs
Itoh, H
,
Tsukamoto, T
,
Kozasa, T
,
Matsuoka, M
,
Kaziro, Y
,
Toyama, R
J Biol Chem
1988
Participants
Input
Heterotrimeric G-protein Gi (inactive) [plasma membrane]
(Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane]
(Homo sapiens)
Output
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane]
(Homo sapiens)
Participates
as an event of
G alpha (i) signalling events (Homo sapiens)
Orthologous Events
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Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Drosophila melanogaster)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Gallus gallus)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Mus musculus)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Sus scrofa)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Xenopus tropicalis)
Authored
Jupe, S (2010-05-18)
Reviewed
D'Eustachio, P (2010-05-22)
Created
Jupe, S (2010-05-18)
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