Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

Stable Identifier
R-HSA-749456
Type
Reaction [binding]
Species
Homo sapiens
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Many unrelated GPCRs couple with the Gi G-protein subtype. The G-alpha (i) subunit inhibits the production of cAMP from ATP. In turn, this results in decreased activity of cAMP-dependent protein kinase. There are 8 types of G-alpha (i) known to date:G(i)1, G(i)2, G(i)3, G(i)o, G(i)z, G(i)gust (gustducin) and two G(i)t (retinal transducin) (Downes GB and Gautam N, 1999). Once GDP is exchanged for GTP on the alpha subunit, it dissociates from the G-beta-gamma subunit.

Literature References
PubMed ID Title Journal Year
2834384 Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs

Itoh, H, Toyama, R, Kozasa, T, Tsukamoto, T, Matsuoka, M, Kaziro, Y

J Biol Chem 1988
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