E2F6 binds RAD51 gene promoter

Stable Identifier
R-HSA-9007546
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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E2F6 binds RAD51 gene promoter
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E2F6, presumably in complex with at least TFDP1 (DP-1) or TFDP2 (DP-2), binds the promoter of the RAD51 gene. Binding of E2F6 to the RAD51 promoter is inhibited by CHEK1-mediated phosphorylation of E2F6 (Bertoli et al. 2013).

Literature References
PubMed ID Title Journal Year
23954429 Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription

Bertoli, C, McGowan, C, Klier, S, Wittenberg, C, de Bruin, RA

Curr. Biol. 2013
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Output
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as an event of
This event is regulated
Negatively by
Regulator
p-S317,S345-CHEK1 [nucleoplasm] (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-06-01)
Reviewed
Herlihy, A  (2017-05-12)
Created
Orlic-Milacic, M  (2017-05-31)
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