Reactome | CTSL2 [lysosomal lumen]

CTSL2 [lysosomal lumen]

Stable Identifier

R-HSA-1181232

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

Synonyms

Cathepsin L2, CATL2_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates transcription of genes involved in differentiation of keratinocytes (Homo sapiens)
        
        SERPINB13 binds cathepsin L (Homo sapiens)
        
        Cathepsin L [lysosomal lumen] (Homo sapiens)
        
        CTSL2 [lysosomal lumen] (Homo sapiens)
        
        SERPINB13:cathepsin L [lysosomal lumen] (Homo sapiens)
        
        Cathepsin L [lysosomal lumen] (Homo sapiens)
        
        CTSL2 [lysosomal lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60911 CTSV

Gene Names

CTSV, CATL2, CTSL2, CTSU, UNQ268/PRO305

Chain

signal peptide:1-17, propeptide:18-113, chain:114-334

Reference Genes

BioGPS Gene:1515 CTSV

COSMIC (genes):CTSV CTSV

CTD Gene:1515 CTSV

dbSNP Gene:1515 CTSV

ENSEMBL:ENSG00000136943 CTSV

ENSEMBL_homo_sapiens_GENE:ENSG00000136943.12 CTSV

HGNC:2538 CTSV

KEGG Gene (Homo sapiens):1515 CTSV

Monarch:1515 CTSV

NCBI Gene:1515 CTSV

OMIM:603308 CTSV

UCSC:O60911 CTSV

Reference Transcript

Other Identifiers

11748773_a_at

11748774_x_at

11755521_a_at

1515

17096285

210074_PM_at

210074_at

3178170

3178184

3216675

3216676

3216677

3216679

3216680

3216684

3216686

3216687

3216689

3216690

3216691

3216692

3216693

3216694

3287613

3288119

40717_at

8162652

A_21_P0013703

A_23_P146456

GE53032

GE545996

GE794882

GO:0002376

GO:0003824

GO:0004197

GO:0004252

GO:0005515

GO:0005576

GO:0005615

GO:0005764

GO:0005773

GO:0006508

GO:0006915

GO:0006955

GO:0008233

GO:0008234

GO:0008656

GO:0012501

GO:0016787

GO:0019886

GO:0022617

GO:0023052

GO:0030163

GO:0030198

GO:0043202

GO:0043226

GO:0051603

GO:0098772

GO:0140096

GO:2001235

HMNXSV003019892

Hs2.353110.1.S1_3p_at

Hs2.353110.1.S1_3p_x_at

ILMN_1748352

PH_hs_0031390

TC09001381.hg

g3228671_3p_at

p16864

Participates

as a candidate of

Cathepsin [lysosomal lumen] (Homo sapiens)

as a member of

Other forms of this molecule

CTSL2 [early endosome lumen]

CTSL2 [extracellular region]

CTSL2 [endolysosome lumen]

Inferred To

im:6910535 [lysosomal lumen] (Danio rerio)

FP3 [lysosomal lumen] (Plasmodium falciparum)

si:dkey-239j18.2 [lysosomal lumen] (Danio rerio)

FP2B [lysosomal lumen] (Plasmodium falciparum)

ctsl.1 [lysosomal lumen] (Danio rerio)

CTSL [lysosomal lumen] (Bos taurus)

CTSL [lysosomal lumen] (Canis familiaris)

CTSL [lysosomal lumen] (Sus scrofa)

ctsl [lysosomal lumen] (Danio rerio)

cpl-1 [lysosomal lumen] (Caenorhabditis elegans)

Ctsl [lysosomal lumen] (Mus musculus)

Ctsl [lysosomal lumen] (Rattus norvegicus)

Homologues of CTSL2 [lysosomal lumen] (Danio rerio)

Homologues of CTSL2 [lysosomal lumen] (Plasmodium falciparum)

CTSL2 [lysosomal lumen] (Plasmodium falciparum)

cprB [lysosomal lumen] (Dictyostelium discoideum)

FP2A [lysosomal lumen] (Plasmodium falciparum)

ctsv [lysosomal lumen] (Xenopus tropicalis)

CTSV [lysosomal lumen] (Gallus gallus)

CtsL1 [lysosomal lumen] (Drosophila melanogaster)

Cross References

RefSeq

NP_001188504.1, NP_001324.2

ZINC - World Drugs

CATL2_HUMAN

Guide to Pharmacology - Targets

2352

OpenTargets

ENSG00000136943

ZINC - FDA approved

CATL2_HUMAN

ZINC - Substances

CATL2_HUMAN

ZINC - Biogenic

CATL2_HUMAN

ZINC target

O60911

PRO

O60911

PDB

7QFH, 7Q8Q, 7Q8H, 7Q8P, 7Q8I, 7QGW, 7Q8N, 7Q8G, 7Q8O, 7QFF, 7Q9H, 7QO2, 7QNS, 1FH0, 7Q8L, 7Q8M, 7Q8F, 7Q8D, 7QHJ, 7Q8J, 3KFQ, 7Q8K, 7PK4, 3H6S, 7QHK

ZINC - Investigational

CATL2_HUMAN

ZINC - Metabolites

CATL2_HUMAN

GeneCards

O60911

HPA

ENSG00000136943-CTSV

Ensembl

ENSP00000259470, ENSG00000136943, ENST00000679661, ENSP00000505681, ENSP00000505141, ENST00000259470, ENST00000681737, ENSP00000506713, ENST00000681927

Pharos - Targets

O60911

ZINC - Predictions - Purchasable

CATL2_HUMAN

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P43235 CTSK	3	CTSK [lysosomal lumen] (R-HSA-1181226) CTSK [extracellular region] (R-HSA-2470897) CTSK [endolysosome lumen] (R-HSA-1678985)	0.527	2
UniProt:Q15915 ZIC1	1	ZIC1 [nucleoplasm] (R-HSA-9731648)	0.527	2
UniProt:Q9NYY3 PLK2	1	PLK2 [cytosol] (R-HSA-6801636)	0.527	2
UniProt:P01160 NPPA	5	NPPA(124-151) [extracellular region] (R-HSA-5578799) NPPA(1-151) [extracellular region] (R-HSA-976950) NPPA(1-25) [extracellular region] (R-HSA-5578791) NPPA(56-123) [extracellular region] (R-HSA-5578797) NPPA(26-55) [extracellular region] (R-HSA-5578794)	0.527	2

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