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PLA2G10 [extracellular region]
Stable Identifier
R-HSA-1498793
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Group 10 secretory phospholipase A2, sPLA2-X
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
Glycerophospholipid biosynthesis (Homo sapiens)
Acyl chain remodelling of PC (Homo sapiens)
PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Homo sapiens)
PLA2(16) [extracellular region] (Homo sapiens)
PLA2G10:Ca2+ [extracellular region] (Homo sapiens)
PLA2G10 [extracellular region] (Homo sapiens)
Acyl chain remodelling of PE (Homo sapiens)
PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Homo sapiens)
PLA2(16) [extracellular region] (Homo sapiens)
PLA2G10:Ca2+ [extracellular region] (Homo sapiens)
PLA2G10 [extracellular region] (Homo sapiens)
Acyl chain remodelling of PG (Homo sapiens)
PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Homo sapiens)
PLA2(16) [extracellular region] (Homo sapiens)
PLA2G10:Ca2+ [extracellular region] (Homo sapiens)
PLA2G10 [extracellular region] (Homo sapiens)
Acyl chain remodelling of PI (Homo sapiens)
PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Homo sapiens)
PLA2(15) [extracellular region] (Homo sapiens)
PLA2G10:Ca2+ [extracellular region] (Homo sapiens)
PLA2G10 [extracellular region] (Homo sapiens)
Acyl chain remodelling of PS (Homo sapiens)
PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Homo sapiens)
PLA2(15) [extracellular region] (Homo sapiens)
PLA2G10:Ca2+ [extracellular region] (Homo sapiens)
PLA2G10 [extracellular region] (Homo sapiens)
Synthesis of PA (Homo sapiens)
PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Homo sapiens)
PLA2(15) [extracellular region] (Homo sapiens)
PLA2G10:Ca2+ [extracellular region] (Homo sapiens)
PLA2G10 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15496 PLA2G10
Gene Names
PLA2G10
Chain
signal peptide:1-31, propeptide:32-42, chain:43-165
Reference Genes
BioGPS Gene:8399 PLA2G10
COSMIC (genes):PLA2G10 PLA2G10
CTD Gene:8399 PLA2G10
dbSNP Gene:8399 PLA2G10
ENSEMBL:ENSG00000069764 PLA2G10
HGNC:9029 PLA2G10
Monarch:8399 PLA2G10
NCBI Gene:8399 PLA2G10
OMIM:603603 PLA2G10
UCSC:O15496 PLA2G10
Reference Transcript
RefSeq:NM_003561.2 PLA2G10
Other Identifiers
100652777
11730699_at
16824109
17121440
207222_PM_at
207222_at
33052_at
3648396
3649585
3649651
3650604
3650651
3651757
3654506
3654610
3655306
3655497
3656083
3667026
3667077
3681491
3681492
3681493
3681495
3681498
3681502
3681503
3681504
3681505
3681506
3681525
3681526
3681527
3681530
3681531
3681532
3681533
3681556
3681557
3681559
3681560
3681638
3682291
3682331
3684957
3686663
3686685
3686855
3686868
3698869
3779196
7999588
8399
ADDON001942.hg
A_21_P0011456
A_23_P88767
GE59596
GO:0001516
GO:0001669
GO:0002376
GO:0002532
GO:0003824
GO:0003847
GO:0004620
GO:0004623
GO:0005509
GO:0005515
GO:0005543
GO:0005576
GO:0005615
GO:0005764
GO:0005773
GO:0006355
GO:0006575
GO:0006629
GO:0006644
GO:0006658
GO:0007411
GO:0008289
GO:0009566
GO:0010744
GO:0010884
GO:0016042
GO:0016787
GO:0019369
GO:0022414
GO:0031069
GO:0031410
GO:0032308
GO:0034374
GO:0034638
GO:0036335
GO:0042116
GO:0042632
GO:0043030
GO:0043226
GO:0043249
GO:0043433
GO:0046337
GO:0046470
GO:0046471
GO:0046473
GO:0046872
GO:0047498
GO:0050482
GO:0050728
GO:0051247
GO:0051607
GO:0051977
GO:0062234
GO:0090238
GO:0090370
GO:0098542
GO:1900016
GO:1990830
GO:2000344
HMNXSV003011260
HMNXSV003032064
ILMN_1762561
PH_hs_0008541
TC16000885.hg
TC16001782.hg
g4505844_3p_at
Participates
as a component of
PLA2G10:Ca2+ [extracellular region] (Homo sapiens)
Inferred To
PLA2G10 [extracellular region]
(Bos taurus)
PLA2G10 [extracellular region]
(Caenorhabditis elegans)
PLA2G10 [extracellular region]
(Canis familiaris)
PLA2G10 [extracellular region]
(Danio rerio)
PLA2G10 [extracellular region]
(Drosophila melanogaster)
PLA2G10 [extracellular region]
(Gallus gallus)
PLA2G10 [extracellular region]
(Mus musculus)
PLA2G10 [extracellular region]
(Rattus norvegicus)
PLA2G10 [extracellular region]
(Sus scrofa)
PLA2G10 [extracellular region]
(Xenopus tropicalis)
Homologues of PLA2G10 [extracellular region]
(Caenorhabditis elegans)
Cross References
Guide to Pharmacology - Targets
1422
OpenTargets
ENSG00000069764
ENSEMBL
ENST00000621727
,
ENSP00000393847
,
ENSP00000479397
,
ENST00000438167
ZINC - Substances
PA2GX_HUMAN
ZINC target
O15496
PRO
O15496
GlyGen
O15496
PDB
6G5J
,
1LE6
,
1LE7
,
5G3M
,
5OW8
,
5OWC
,
4UY1
ZINC - Investigational
PA2GX_HUMAN
HPA
ENSG00000069764-PLA2G10
Pharos - Targets
O15496
ZINC - Predictions - Purchasable
PA2GX_HUMAN
HMDB Protein
HMDBP00063
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95947 TBX6
1
TBX6 [nucleoplasm]
(R-HSA-9793377)
0.556
3
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.556
3
UniProt:Q01974 ROR2
2
ROR2 [plasma membrane]
(R-HSA-197731)
ROR2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5140729)
0.556
3
UniProt:O75593 FOXH1
1
FOXH1 [nucleoplasm]
(R-HSA-1225914)
0.556
3
UniProt:P31273 HOXC8
1
HOXC8 [nucleoplasm]
(R-HSA-3222311)
0.556
3
UniProt:Q70CQ3 USP30
2
USP30 [mitochondrial outer membrane]
(R-HSA-5696931)
USP30 [peroxisomal membrane]
(R-HSA-9674135)
0.527
2
UniProt:Q14159 SPIDR
1
SPIDR [nucleoplasm]
(R-HSA-5686408)
0.527
2
UniProt:Q8IYL2 TRMT44
1
TRMT44 [cytosol]
(R-HSA-6788685)
0.527
2
UniProt:P62987 UBA52
20
UBA52(1-76) [endocytic vesicle membrane]
(R-HSA-939236)
Ub-33-UBA52(1-76) [mitochondrial outer membrane]
(R-HSA-6783187)
Ub-63-UBA52(1-76) [mitochondrial outer membrane]
(R-HSA-6783039)
Ub-6-UBA52(1-76) [mitochondrial outer membrane]
(R-HSA-6783072)
Ub-11-UBA52(1-76) [mitochondrial outer membrane]
(R-HSA-6783059)
Ub-48-UBA52(1-76) [mitochondrial outer membrane]
(R-HSA-6783049)
Ub-29-UBA52(1-76) [mitochondrial outer membrane]
(R-HSA-6783030)
Ub-63-UBA52(1-76) [cytosol]
(R-HSA-939169)
UBA52(1-76) [lysosomal lumen]
(R-HSA-9660000)
UBA52(1-76) [cytosol]
(R-HSA-939203)
p-S65-UBA52(1-76) [mitochondrial outer membrane]
(R-HSA-9834996)
Ub-48-UBA52(1-76) [cytosol]
(R-HSA-939250)
UBA52(1-76) [mitochondrial outer membrane]
(R-HSA-9834955)
UBA52(1-76) [late endosome lumen]
(R-HSA-9660003)
Ub-6-UBA52(1-76) [nucleoplasm]
(R-HSA-6782616)
Ub-63-UBA52(1-76) [nucleoplasm]
(R-HSA-6782530)
Ub-48-UBA52(1-76) [nucleoplasm]
(R-HSA-5683034)
UBA52(1-76) [nucleoplasm]
(R-HSA-939844)
Ub-11-UBA52(1-76) [cytosol]
(R-HSA-3095931)
Ub-63-UBA52(1-76) [plasma membrane]
(R-HSA-939851)
0.527
2
UniProt:Q9UQ49 NEU3
1
NEU3 [plasma membrane]
(R-HSA-1605644)
0.527
2
UniProt:O96014 WNT11
9
N4GlycoAsn-PalmS WNT11 [extracellular region]
(R-HSA-3247797)
N4GlycoAsn-PalmS WNT11 [plasma membrane]
(R-HSA-3247792)
N4GlycoAsn-PalmS WNT11 [Golgi lumen]
(R-HSA-3247823)
N4GlycoAsn-PalmS WNT11 [endoplasmic reticulum lumen]
(R-HSA-3238335)
N4GlycoAsn-WNT11 [endoplasmic reticulum lumen]
(R-HSA-3238222)
WNT11 [endoplasmic reticulum lumen]
(R-HSA-3238281)
N4GlycoAsn-PalmS WNT11 [endocytic vesicle membrane]
(R-HSA-3781987)
N4GlycoAsn-PalmS WNT11 [extracellular exosome]
(R-HSA-3781980)
WNT11 [extracellular region]
(R-HSA-517473)
0.527
2
UniProt:O14757 CHEK1
3
p-S317,S345-CHEK1 [nucleoplasm]
(R-HSA-113838)
CHEK1 [nucleoplasm]
(R-HSA-113826)
CHEK1 [cytosol]
(R-HSA-205285)
0.527
2
UniProt:O14965 AURKA
6
p-T288-AURKA [cytosol]
(R-HSA-2574832)
AURKA [cytosol]
(R-HSA-174254)
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
AURKA [nucleoplasm]
(R-HSA-4655443)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
0.527
2
UniProt:P01137 TGFB1
7
TGFB1 [extracellular region]
(R-HSA-170838)
TGFB1(30-278) [extracellular region]
(R-HSA-2395367)
TGFB1(30-278) [Golgi lumen]
(R-HSA-9736812)
TGFB1 [Golgi lumen]
(R-HSA-177108)
TGFB1(30-390) [Golgi lumen]
(R-HSA-114705)
TGFB1 [plasma membrane]
(R-HSA-5146781)
TGFB1(30-278) [platelet alpha granule lumen]
(R-HSA-65936)
0.527
2
UniProt:Q92824 PCSK5
2
PCSK5 [extracellular region]
(R-HSA-6784682)
PCSK5(115-913) [Golgi lumen]
(R-HSA-166558)
0.527
2
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