Reactome | ROR2 [plasma membrane]

ROR2 [plasma membrane]

Stable Identifier

R-HSA-197731

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Tyrosine-protein kinase transmembrane receptor ROR2 precursor, ROR2_HUMAN

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External Reference Information

External Reference

UniProt:Q01974 ROR2

Gene Names

ROR2, NTRKR2

Chain

signal peptide:1-33, chain:34-943

Reference Genes

BioGPS Gene:4920 ROR2

COSMIC (genes):ROR2 ROR2

CTD Gene:4920 ROR2

dbSNP Gene:4920 ROR2

ENSEMBL:ENSG00000169071 ROR2

HGNC:10257 ROR2

KEGG:hsa:4920 ROR2

Monarch:4920 ROR2

NCBI Gene:4920 ROR2

OMIM:602337 ROR2

UCSC:Q01974 ROR2

Reference Transcript

Other Identifiers

11736905_a_at

11736906_a_at

11754365_s_at

17095712

205578_PM_at

205578_at

212_at

3214497

3214498

3214499

3214500

3214501

3214502

3214503

3214505

3214507

3214508

3214510

3214511

3214512

3214513

3214518

3214530

3214534

3214535

3214543

3214544

3214545

3214547

3214548

3214576

4920

8162283

89334_at

A_23_P158318

A_24_P101704

GE58180

GO:0002376

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005515

GO:0005524

GO:0005874

GO:0005886

GO:0006468

GO:0007165

GO:0007169

GO:0009986

GO:0010976

GO:0014002

GO:0015026

GO:0016020

GO:0016055

GO:0016301

GO:0016740

GO:0017147

GO:0022414

GO:0030282

GO:0030335

GO:0030425

GO:0030539

GO:0030669

GO:0031435

GO:0043025

GO:0043235

GO:0045651

GO:0046872

GO:0048856

GO:0048870

GO:0050804

GO:0051897

GO:0051968

GO:0060089

GO:0098794

GO:0098978

GO:0099175

GO:0140096

GO:0150045

GO:1905517

HMNXSV003021078

ILMN_1694426

M97639_at

PH_hs_0023044

TC09001326.hg

g4758841_3p_at

Participates

as a component of

as an input of

WNT5A binds ROR2 and VANGL2 (Homo sapiens)

as a member of

FZD2/FZD5/ROR2 [plasma membrane] (Homo sapiens)

Other forms of this molecule

ROR2 [clathrin-coated endocytic vesicle membrane]

Inferred To

ROR2 [plasma membrane] (Bos taurus)

ROR2 [plasma membrane] (Caenorhabditis elegans)

ROR2 [plasma membrane] (Canis familiaris)

ROR2 [plasma membrane] (Danio rerio)

ROR2 [plasma membrane] (Drosophila melanogaster)

ROR2 [plasma membrane] (Gallus gallus)

ROR2 [plasma membrane] (Mus musculus)

ROR2 [plasma membrane] (Sus scrofa)

ROR2 [plasma membrane] (Xenopus tropicalis)

Ror2 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001305133.1, NP_004551.2

Guide to Pharmacology - Targets

1846

ENSEMBL

ENST00000375708, ENSP00000364860

OpenTargets

ENSG00000169071

HPA

ENSG00000169071-ROR2

PRO

Q01974

Pharos - Targets

Q01974

GlyGen

Q01974

Orphanet

ROR2

HMDB Protein

HMDBP01178

PDB

6OSV, 6OSN, 4GT4, 3ZZW, 6OSH

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43186 CRX			0.666	4
UniProt:O95231 VENTX	1	VENTX [nucleoplasm] (R-HSA-8853887)	0.556	3
UniProt:Q16633 OBF1			0.556	3
UniProt:A4D0Q3 A4D0Q3			0.556	3
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.556	3
IntAct:EBI-22404606 CCSB ORF ID			0.556	3
UniProt:P78337 PITX1			0.556	3
UniProt:Q9UPM6 LHX6			0.556	3
UniProt:O95416 SOX14			0.556	5
UniProt:O43741 PRKAB2	2	PRKAB2 [cytosol] (R-HSA-200413) PRKAB2 [nucleoplasm] (R-HSA-164096)	0.556	3
IntAct:EBI-22317115 CCSB ORF ID			0.556	3
UniProt:O15496 PLA2G10	1	PLA2G10 [extracellular region] (R-HSA-1498793)	0.556	3
UniProt:P53539 FOSB	1	FOSB [nucleoplasm] (R-HSA-9009922)	0.556	3
UniProt:A1KXE4-2 FAM168B			0.556	3
UniProt:P86480 PR20D			0.556	3
UniProt:Q03989 ARI5A			0.556	3
UniProt:Q8N813 PR23E			0.556	3
UniProt:Q3SYF9 KRTAP19-7	1	KRTAP19-7 [cytosol] (R-HSA-6810305)	0.556	3
UniProt:Q9NP73-4 ALG13			0.556	3
UniProt:Q15038 DAZP2			0.556	8
UniProt:O43711 TLX3			0.556	3
IntAct:EBI-22616457 CCSB ORF ID			0.556	3
UniProt:Q2M1V0 ISX			0.556	3
UniProt:Q5BKX5-3 ACTMAP			0.556	3
UniProt:Q03060-25 CREM			0.556	3
UniProt:Q5SWW7 CJ055			0.556	3
UniProt:Q6P1W5 CA094			0.556	3
UniProt:P35548 MSX2	1	MSX2 [nucleoplasm] (R-HSA-9007760)	0.556	3
UniProt:Q6ZVD7 STOX1			0.556	3
UniProt:Q8IUC3 KRA71			0.556	3
UniProt:Q3LI66 KRTAP6-2	1	KRTAP6-2 [cytosol] (R-HSA-6810261)	0.556	3
UniProt:P10321 HLA-C	8	HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [phagocytic vesicle membrane] (R-HSA-1236760) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane] (R-HSA-8863915) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [early endosome membrane] (R-HSA-1236799) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-983354) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [Golgi membrane] (R-HSA-983387) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane] (R-HSA-199595) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [secretory granule membrane] (R-HSA-6803292) HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-983044)	0.527	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.524	2
UniProt:Q15750 TAB1	6	TAB1 [cytosol] (R-HSA-167923) TAB1 [endosome membrane] (R-HSA-450238) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(445-504) [cytosol] (R-HSA-9729691)	0.519	2

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