Reactome | ATP5C1 [mitochondrial matrix]

ATP5C1 [mitochondrial matrix]

Stable Identifier

R-HSA-164577

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

ATP synthase gamma chain

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
    - Formation of ATP by chemiosmotic coupling (Homo sapiens)
      - ADP and Pi bind to ATPase (Homo sapiens)
        
        ATPase:ADP:Pi [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5C1 [mitochondrial matrix] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5C1 [mitochondrial matrix] (Homo sapiens)
      - ATPase synthesizes ATP (Homo sapiens)
        
        ATPase:ADP:Pi [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5C1 [mitochondrial matrix] (Homo sapiens)
        
        ATPase:ATP [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5C1 [mitochondrial matrix] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5C1 [mitochondrial matrix] (Homo sapiens)
      - Enzyme-bound ATP is released (Homo sapiens)
        
        ATPase:ATP [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5C1 [mitochondrial matrix] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5C1 [mitochondrial matrix] (Homo sapiens)

Organelle biogenesis and maintenance (Homo sapiens)

- Mitochondrial biogenesis (Homo sapiens)
  - Cristae formation (Homo sapiens)
    - F1Fo ATP synthase dimerizes (Homo sapiens)
      - F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5C1 [mitochondrial matrix] (Homo sapiens)
      - F1Fo ATP synthase dimer [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5C1 [mitochondrial matrix] (Homo sapiens)

External Reference Information

External Reference

UniProt:P36542 ATP5F1C

Gene Names

ATP5F1C, ATP5C, ATP5C1, ATP5CL1

Chain

transit peptide:1-25, chain:26-298

Reference Genes

BioGPS Gene:509 ATP5F1C

COSMIC (genes):ATP5F1C ATP5F1C

CTD Gene:509 ATP5F1C

dbSNP Gene:509 ATP5F1C

ENSEMBL:ENSG00000165629 ATP5C1

ENSEMBL:ENSG00000165629.20 ATP5F1C

HGNC:833 ATP5F1C

KEGG Gene (Homo sapiens):509 ATP5F1C

Monarch:509 ATP5F1C

NCBI Gene:509 ATP5F1C

OMIM:108729 ATP5F1C

UCSC:P36542 ATP5F1C

Reference Transcript

Other Identifiers

11749392_a_at

11758727_x_at

16702311

205711_PM_x_at

205711_x_at

208870_PM_x_at

208870_x_at

213366_PM_x_at

213366_x_at

3234141

3234142

3234148

3234152

3234153

3234155

3234158

3234159

3234161

3234165

3234166

3234173

3234175

40115_at

509

7926084

A_23_P63655

D16562_at

GE57100

GO:0000275

GO:0003723

GO:0003824

GO:0005215

GO:0005515

GO:0005739

GO:0005743

GO:0005753

GO:0005759

GO:0006091

GO:0006119

GO:0006754

GO:0006811

GO:0015986

GO:0016020

GO:0016787

GO:0016874

GO:0016887

GO:0042776

GO:0043226

GO:0045261

GO:0046933

GO:0055085

GO:0055086

GO:0110165

GO:0140657

GO:1901135

GO:1902600

HMNXSV003013331

Hs.155433.3.A1_3p_a_at

ILMN_1685774

ILMN_1701269

PH_hs_0009363

TC10000067.hg

Participates

as a component of

ATPase CF(1) [mitochondrial matrix] (Homo sapiens)

Inferred To

ATP5F1C [mitochondrial matrix] (Bos taurus)

ATP5F1C [mitochondrial matrix] (Canis familiaris)

ATP5F1C [mitochondrial matrix] (Sus scrofa)

ATP5C1 [mitochondrial matrix] (Caenorhabditis elegans)

ATP5C1 [mitochondrial matrix] (Danio rerio)

ATP5C1 [mitochondrial matrix] (Gallus gallus)

ATPsyngamma [mitochondrial matrix] (Drosophila melanogaster)

Atp5f1c [mitochondrial matrix] (Mus musculus)

Atp5f1c [mitochondrial matrix] (Rattus norvegicus)

Cross References

RefSeq

NP_001001973.1, NP_005165.1

Guide to Pharmacology - Targets

798

OpenTargets

ENSG00000165629

GeneCards

P36542

HPA

ENSG00000165629-ATP5F1C

Ensembl

ENSG00000165629, ENST00000356708, ENST00000335698, ENSP00000349142, ENSP00000338568

PRO

P36542

Pharos - Targets

P36542

HMDB Protein

HMDBP01343

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q96H96 COQ2	4	COQ2(1-371) [mitochondrial intermembrane space] (R-HSA-1267977) COQ2(1-34) [mitochondrial matrix] (R-HSA-8986157) COQ2(1-371) [mitochondrial inner membrane] (R-HSA-1299452) COQ2 [mitochondrial inner membrane] (R-HSA-1299439)	0.527	4
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12

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