Reactome | PPP2R1B [nucleoplasm]

PPP2R1B [nucleoplasm]

Stable Identifier

R-HSA-166000

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PP2A-subunit A beta isoform

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        CCNG1 recruits PP2A-PPP2R5C to MDM2 (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-subunit A [nucleoplasm] (Homo sapiens)
        
        PPP2R1B [nucleoplasm] (Homo sapiens)
        
        PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm] (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-subunit A [nucleoplasm] (Homo sapiens)
        
        PPP2R1B [nucleoplasm] (Homo sapiens)
        
        PP2A-PP2R5C dephosphorylates MDM2 (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-subunit A [nucleoplasm] (Homo sapiens)
        
        PPP2R1B [nucleoplasm] (Homo sapiens)
        
        PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm] (Homo sapiens)
        
        PP2A-PPP2R5C [nucleoplasm] (Homo sapiens)
        
        PP2A-subunit A [nucleoplasm] (Homo sapiens)
        
        PPP2R1B [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P30154 PPP2R1B

Gene Names

PPP2R1B

Chain

initiator methionine:, chain:2-601

Reference Genes

BioGPS Gene:5519 PPP2R1B

COSMIC (genes):PPP2R1B PPP2R1B

CTD Gene:5519 PPP2R1B

dbSNP Gene:5519 PPP2R1B

ENSEMBL:ENSG00000137713 PPP2R1B

HGNC:9303 PPP2R1B

KEGG:hsa:5519 PPP2R1B

Monarch:5519 PPP2R1B

NCBI Gene:5519 PPP2R1B

OMIM:603113 PPP2R1B

UCSC:P30154 PPP2R1B

Reference Transcript

Other Identifiers

1093_at

1094_g_at

11731881_a_at

11733784_at

11733785_at

11747147_a_at

16744289

202883_PM_s_at

202883_s_at

202884_PM_s_at

202884_s_at

202885_PM_s_at

202885_s_at

202886_PM_s_at

202886_s_at

222351_PM_at

222351_at

3391028

3391030

3391031

3391037

3391038

3391039

3391040

3391041

3391042

3391043

3391044

3391045

3391046

3391047

3391048

3391049

3391052

3391055

3391056

3391057

3391059

3391060

3391061

3391062

3391063

3391066

3391067

3391069

3391070

3391071

3391072

41429_at

53816_i_at

54307_r_at

5519

56320_at

65331_at

65332_g_at

72441_at

7951614

A_23_P52793

A_24_P107291

A_24_P98762

GE80019

GO:0000159

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0012501

GO:0019888

GO:0043226

GO:0045121

GO:0060561

GO:0070062

GO:0098772

GO:2001241

HMNXSV003022219

HMNXSV003049074

Hs.108705.0.S3_3p_a_at

Hs.168737.0.A1_3p_at

ILMN_1704656

ILMN_1709247

ILMN_1779841

M65254_at

PH_hs_0025221

TC11002283.hg

TC11002284.hg

g11386166_3p_a_at

g11386166_3p_s_at

g11692008_3p_a_at

g189429_3p_a_at

Participates

as a candidate of

PP2A-subunit A [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PPP2R1B [cytosol]

Inferred To

TPD3 [nucleoplasm] (Saccharomyces cerevisiae)

paa-1 [nucleoplasm] (Caenorhabditis elegans)

ppp2r1b [nucleoplasm] (Xenopus tropicalis)

ppp2r1bb [nucleoplasm] (Danio rerio)

pppA [nucleoplasm] (Dictyostelium discoideum)

Pp2A-29B [nucleoplasm] (Drosophila melanogaster)

PPP2R1B [nucleoplasm] (Bos taurus)

PPP2R1B [nucleoplasm] (Canis familiaris)

PPP2R1B [nucleoplasm] (Sus scrofa)

Ppp2r1b [nucleoplasm] (Mus musculus)

Ppp2r1b [nucleoplasm] (Rattus norvegicus)

paa1 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_859051.1, NP_001171034.1, NP_001171033.1, NP_859050.1, NP_002707.3

ENSEMBL

ENSP00000311344, ENSP00000437193, ENST00000393055, ENSP00000376775, ENST00000527614, ENST00000341980, ENSP00000410671, ENST00000311129, ENST00000426998, ENSP00000343317

OpenTargets

ENSG00000137713

HPA

ENSG00000137713-PPP2R1B

PRO

P30154

Pharos - Targets

P30154

GlyGen

P30154

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.919	9
UniProt:P63151 PPP2R2A	2	PPP2R2A [nucleoplasm] (R-HSA-1564978) PPP2R2A [cytosol] (R-HSA-377253)	0.727	5
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.725	5
UniProt:Q9Y6E0 STK24	4	STK24 [cytosol] (R-HSA-351829) STK24(1-313) [cytosol] (R-HSA-351892) STK24(314-443) [cytosol] (R-HSA-351898) STK24(1-313) [nucleoplasm] (R-HSA-351944)	0.643	3
UniProt:O08722 Unc5b	1	Unc5b [plasma membrane] (R-RNO-421655)	0.616	4
UniProt:Q9BRV8 SIKE1	1	SIKE1 [cytosol] (R-HSA-916828)	0.527	2
UniProt:O08785 Clock	2	p-S-Clock [nucleoplasm] (R-MMU-508670) Clock [cytosol] (R-MMU-508720)	0.508	2
UniProt:P11233 RALA	2	RALA [cytosol] (R-HSA-170988) GGC-RALA [cytoplasmic vesicle membrane] (R-HSA-1458479)	0.499	6

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