Reactome | Synthesis of IPs in the nucleus

Synthesis of IPs in the nucleus

Stable Identifier

R-HSA-1855191

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Within the nucleus, inositol polyphosphate multikinase (IPMK), inositol-pentakisphosphate 2-kinase (IPPK), inositol hexakisphosphate kinase 1 (IP6K1) and 2 (IP6K2) produce IP5, IP6, IP7, and IP8 inositol phosphate molecules (Irvine & Schell 2001, Alcazar-Romain & Wente 2008, York 2006, Monserrate and York 2010, Nalaskowski et al. 2002, Chang et al. 2002, Chang & Majerus 2006, Saiardi et al. 2001, Saiardi et al. 2000, Draskovic et al. 2008, Mulugu et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
20359876	Inositol phosphate synthesis and the nuclear processes they affect Monserrate, JP, York, JD	Curr Opin Cell Biol	2010
10827188	The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis Saiardi, A, Snyder, SH, Caffrey, JJ, Shears, SB	J Biol Chem	2000
17943301	Inositol polyphosphates: a new frontier for regulating gene expression Wente, SR, Alcázar-Román, AR	Chromosoma	2008
16293229	Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate Majerus, PW, Chang, SC	Biochem Biophys Res Commun	2006
11331907	Back in the water: the return of the inositol phosphates Schell, MJ, Irvine, RF	Nat Rev Mol Cell Biol	2001
18355727	Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups Ilc, G, Bhandari, R, Burton, A, Kovacevic, M, Saiardi, A, Podobnik, M, Snyder, SH, Draskovic, P	Chem Biol	2008
11502751	Identification and characterization of a novel inositol hexakisphosphate kinase Nagata, E, Saiardi, A, Snyder, SH, Snowman, AM, Luo, HR	J Biol Chem	2001
16781889	Regulation of nuclear processes by inositol polyphosphates York, JD	Biochim Biophys Acta	2006
12223481	The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase Wente, SR, Majerus, PW, Feng, Y, Miller, AL, Chang, SC	J Biol Chem	2002
12027805	The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization Nalaskowski, MM, Deschermeier, C, Mayr, GW, Fanick, W	Biochem J	2002
17412958	A conserved family of enzymes that phosphorylate inositol hexakisphosphate Haystead, TA, Dollins, DE, Ribeiro, AA, Otto, JC, Bai, W, York, JD, Mulugu, S, Fridy, PC, Bastidas, RJ	Science	2007