Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ACTR3 [cytosol]
Stable Identifier
R-HSA-200811
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ARP3
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
N-WASP binds ARP2/3 and G-actin (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Branching and elongation of mother and daughter filaments (Homo sapiens)
Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Extension of pseudopodia by myosin-X in a PI3K dependent manner (Homo sapiens)
Actin filament bound Myosin-X [plasma membrane] (Homo sapiens)
Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
IgG:Leishmania surface:FCGR3A translocates from plasma membrane to the parasitophorous vacuole (Homo sapiens)
Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Myosin-Actin filaments [cytosol] (Homo sapiens)
Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Branching and elongation of mother and daughter filaments (Homo sapiens)
Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Extension of pseudopodia by myosin-X in a PI3K dependent manner (Homo sapiens)
Actin filament bound Myosin-X [plasma membrane] (Homo sapiens)
Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Role of myosins in phagosome formation (Homo sapiens)
Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Myosin-Actin filaments [cytosol] (Homo sapiens)
Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Branching and elongation of mother and daughter filaments (Homo sapiens)
Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
ARP2/3 complex (ATP bound) [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ARP2/3 complex [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ARP2/3 complex [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
BAR domain proteins recruit dynamin (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
ARP2/3 complex [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
ARP2/3 complex [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ARP2/3 complex [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ARP2/3 complex [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ARP2/3 complex [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ARP2/3 complex [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Dissociation of clathrin-associated proteins (Homo sapiens)
ARP2/3 complex [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ARP2/3 complex [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ARP2/3 complex [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
ARP2/3 complex [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
ARP2/3 complex [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
ARP2/3 complex [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ARP2/3 complex [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ARP2/3 complex [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ARP2/3 complex [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
ARP2/3 complex [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
ARP2/3 complex [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
ARP2/3 complex [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
ARP2/3 complex [cytosol] (Homo sapiens)
ACTR3:ATP [cytosol] (Homo sapiens)
ACTR3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P61158 ACTR3
Gene Names
ACTR3, ARP3
Chain
initiator methionine:, chain:2-418
Reference Genes
BioGPS Gene:10096 ACTR3
COSMIC (genes):ACTR3 ACTR3
CTD Gene:10096 ACTR3
dbSNP Gene:10096 ACTR3
ENSEMBL:ENSG00000115091 ACTR3
ENSEMBL_homo_sapiens_GENE:ENSG00000115091.12 ACTR3
HGNC:170 ACTR3
KEGG Gene (Homo sapiens):10096 ACTR3
Monarch:10096 ACTR3
NCBI Gene:10096 ACTR3
OMIM:604222 ACTR3
UCSC:P61158 ACTR3
Reference Transcript
RefSeq:NM_005721.4 ACTR3
Other Identifiers
10096
11728643_s_at
11751141_a_at
16884797
200996_PM_at
200996_at
213101_PM_s_at
213101_s_at
213102_PM_at
213102_at
228603_PM_at
228603_at
239170_PM_at
239170_at
2501701
2501702
2501703
2501704
2501711
2501714
2501715
2501716
2501717
2501721
2501722
2501728
2501729
2501731
2501733
2501734
2501735
2501736
2501737
2501738
2501739
2501740
2501741
35271_at
47644_at
54274_at
64157_at
69195_at
8044686
A_24_P105771
A_24_P231513
GE58377
GO:0000166
GO:0000910
GO:0002376
GO:0003779
GO:0005198
GO:0005200
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005694
GO:0005737
GO:0005829
GO:0005856
GO:0005885
GO:0005903
GO:0005911
GO:0005925
GO:0006351
GO:0006355
GO:0007010
GO:0007018
GO:0007059
GO:0007163
GO:0008092
GO:0008356
GO:0010592
GO:0015629
GO:0016020
GO:0016344
GO:0022414
GO:0030027
GO:0030030
GO:0033206
GO:0034314
GO:0035861
GO:0042995
GO:0043226
GO:0044782
GO:0045944
GO:0048870
GO:0051015
GO:0051321
GO:0051653
GO:0060271
GO:0070062
GO:0070358
GO:0071346
GO:0098542
GO:0140013
HMNXSV003015544
HMNXSV003054012
Hs.10927.1.A1_3p_at
Hs.10927.1.A1_3p_s_at
Hs.195789.0.A1_3p_at
Hs.99410.0.A1_3p_at
ILMN_1657153
PH_hs_0020129
TC02000735.hg
g7262289_3p_at
Participates
as a component of
ACTR3:ATP [cytosol] (Homo sapiens)
Inferred To
Arp3 [cytosol]
(Drosophila melanogaster)
act2 [cytosol]
(Schizosaccharomyces pombe)
actr3 [cytosol]
(Danio rerio)
actr3 [cytosol]
(Xenopus tropicalis)
ARP3 [cytosol]
(Bos taurus)
ARP3 [cytosol]
(Saccharomyces cerevisiae)
arx-1 [cytosol]
(Caenorhabditis elegans)
arpC [cytosol]
(Dictyostelium discoideum)
Actr3 [cytosol]
(Mus musculus)
Actr3 [cytosol]
(Rattus norvegicus)
ACTR3 [cytosol]
(Canis familiaris)
ACTR3 [cytosol]
(Gallus gallus)
ACTR3 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_005712.1
OpenTargets
ENSG00000115091
HPA
ENSG00000115091-ACTR3
GeneCards
P61158
Ensembl
ENST00000263238
,
ENSG00000115091
,
ENSP00000263238
PRO
P61158
Pharos - Targets
P61158
PDB
6YW6
,
6YW7
,
8P94
,
6UHC
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
13
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.556
3
UniProt:P10809 HSPD1
6
HSPD1 [mitochondrial matrix]
(R-HSA-1299448)
HSPD1(1-573) [cytosol]
(R-HSA-1267989)
HSPD1(1-573) [mitochondrial intermembrane space]
(R-HSA-1267963)
HSPD1 [mitochondrial inner membrane]
(R-HSA-1299455)
HSPD1(1-573) [mitochondrial inner membrane]
(R-HSA-1299442)
HSPD1(1-26) [mitochondrial matrix]
(R-HSA-8986171)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q00535 CDK5
4
CDK5 [nucleoplasm]
(R-HSA-8863586)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
CDK5 [cytosol]
(R-HSA-180064)
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
0.556
3
UniProt:Q14247 CTTN
2
CTTN [cytosol]
(R-HSA-201894)
p-S113-CTTN [cytosol]
(R-HSA-442842)
0.491
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text