Reactome | STUB1 [cytosol]

STUB1 [cytosol]

Stable Identifier

R-HSA-975970

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase CHIP, CHIP_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UNE7 STUB1

Gene Names

STUB1, CHIP, PP1131

Chain

chain:1-303

Reference Genes

BioGPS Gene:10273 STUB1

COSMIC (genes):STUB1 STUB1

CTD Gene:10273 STUB1

dbSNP Gene:10273 STUB1

ENSEMBL:ENSG00000103266 STUB1

ENSEMBL:ENSG00000103266.11 STUB1

HGNC:11427 STUB1

KEGG Gene (Homo sapiens):10273 STUB1

Monarch:10273 STUB1

NCBI Gene:10273 STUB1

OMIM:607207 STUB1

UCSC:Q9UNE7 STUB1

Reference Transcript

Other Identifiers

10273

11722698_a_at

16814488

217934_PM_x_at

217934_x_at

227625_PM_s_at

227625_s_at

233049_PM_x_at

233049_x_at

3643299

3643300

3643301

3643302

3643303

3643304

3643305

3643306

3643307

3643308

3643309

3643312

3643314

3643316

3643318

3643319

3643320

3643321

3643322

65827_at

7992021

A_23_P37870

GE81568

GO:0000151

GO:0000209

GO:0001664

GO:0002931

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005829

GO:0006281

GO:0006511

GO:0006513

GO:0006515

GO:0006629

GO:0006914

GO:0006974

GO:0008047

GO:0008092

GO:0016567

GO:0016740

GO:0019899

GO:0019900

GO:0023052

GO:0030018

GO:0030163

GO:0030433

GO:0030512

GO:0030544

GO:0030579

GO:0030674

GO:0030911

GO:0030968

GO:0031072

GO:0031371

GO:0031398

GO:0031625

GO:0031647

GO:0031943

GO:0032091

GO:0032436

GO:0034450

GO:0034605

GO:0035033

GO:0036211

GO:0038128

GO:0042405

GO:0042803

GO:0043161

GO:0043226

GO:0045862

GO:0046332

GO:0048156

GO:0050821

GO:0051087

GO:0051443

GO:0051604

GO:0051787

GO:0051865

GO:0051879

GO:0060090

GO:0061630

GO:0061684

GO:0065003

GO:0070534

GO:0071218

GO:0071456

GO:0090035

GO:0098772

GO:0101031

GO:0140096

HMNXSV003009319

Hs.25197.1.S1_3p_a_at

ILMN_1756126

ILMN_2157421

PH_hs_0024981

TC16000026.hg

Participates

as a component of

as an output of

as an input of

as a member of

NEDD4,STUB1,WWP2 and XIAP [cytosol] (Homo sapiens)

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

Stub1 [cytosol] (Mus musculus)

Stub1 [cytosol] (Rattus norvegicus)

wu:fc22f04 [cytosol] (Danio rerio)

STUB1 [cytosol] (Bos taurus)

STUB1 [cytosol] (Canis familiaris)

STUB1 [cytosol] (Drosophila melanogaster)

STUB1 [cytosol] (Gallus gallus)

STUB1 [cytosol] (Plasmodium falciparum)

STUB1 [cytosol] (Sus scrofa)

Ghost homologue of STUB1 [cytosol] (Dictyostelium discoideum)

stub1 [cytosol] (Xenopus tropicalis)

chn-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_005852.2, NP_001280126.1

Guide to Pharmacology - Targets

3202

OpenTargets

ENSG00000103266

IntEnz

2.3.2.27

HPA

ENSG00000103266-STUB1

GeneCards

Q9UNE7

Ensembl

ENST00000565677, ENSP00000456875, ENSP00000457228, ENST00000219548, ENSG00000103266, ENSP00000219548, ENST00000564370

PRO

Q9UNE7

Pharos - Targets

Q9UNE7

Orphanet

22673

HMDB Protein

HMDBP09259

PDB

4KBQ, 8F16, 8F14, 8F17, 8F15, 6NSV, 6EFK, 7TB1

Interactors (79)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.832	8
UniProt:P07900 HSP90AA1	8	HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.831	9
UniProt:P08107 HSP71			0.76	5
UniProt:P61088 UBE2N	5	Ub-C87-UBE2N [nucleoplasm] (R-HSA-8943013) Ub-C87-UBE2N [cytosol] (R-HSA-8864210) K63polyUb-C87-UBE2N [nucleoplasm] (R-HSA-6790511) UBE2N [nucleoplasm] (R-HSA-5682541) UBE2N [cytosol] (R-HSA-206072)	0.75	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.743	5
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.721	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.713	4
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.666	4
UniProt:Q96PB7 NOE3			0.666	4
UniProt:Q13404 UBE2V1	1	UBE2V1 [cytosol] (R-HSA-205753)	0.656	3
UniProt:Q9BZS1 FOXP3	1	FOXP3 [nucleoplasm] (R-HSA-8865539)	0.644	7
UniProt:Q86WG3 ATCAY			0.633	4
UniProt:O95817 BAG3	1	BAG3 [cytosol] (R-HSA-5255451)	0.623	3
UniProt:P22314 UBA1	2	UBA1 [cytosol] (R-HSA-947698) UBA1 [nucleoplasm] (R-HSA-8852116)	0.623	2
UniProt:P53355 DAPK1	1	DAPK1 [cytosol] (R-HSA-418262)	0.59	2
UniProt:Q7Z7E8 UBE2Q1	1	UBE2Q1 [cytosol] (R-HSA-947629)	0.581	3
UniProt:P00540 MOS			0.564	2
UniProt:O95072 REC8	1	REC8 [nucleoplasm] (R-HSA-163028)	0.564	2
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.564	8
UniProt:Q15019-2 SEPTIN2			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.556	3
UniProt:Q9BZ23-2 PANK2			0.556	3
UniProt:P01023 A2M	2	A2M [extracellular region] (R-HSA-49291) A2M [platelet alpha granule lumen] (R-HSA-139834)	0.556	3
UniProt:A0A0S2Z5Q7 A0A0S2Z5Q7			0.556	3
UniProt:Q96PB7-3 OLFM3			0.556	3
UniProt:Q15438 CYTH1	2	CYTH1 [cytosol] (R-HSA-8847826) CYTH1 [Golgi membrane] (R-HSA-8847825)	0.556	3
UniProt:Q9NRJ3 CCL28	1	CCL28 [extracellular region] (R-HSA-373300)	0.556	3
UniProt:J3KQ12 J3KQ12			0.556	3
UniProt:P05164 MPO	6	MPO (165-278) [phagocytic vesicle lumen] (R-HSA-6789179) MPO (279-745) [phagocytic vesicle lumen] (R-HSA-6789038) MPO (165-278) [extracellular region] (R-HSA-6806225) MPO (279-745) [extracellular region] (R-HSA-6806241) MPO (279-745) [azurophil granule lumen] (R-HSA-6799241) MPO (165-278) [azurophil granule lumen] (R-HSA-6799233)	0.556	3
UniProt:P38247 SLM4			0.556	3
UniProt:P32502	1	GCD7 [cytosol] (R-SCE-72519)	0.556	3
UniProt:Q9UGC6 RGS17	1	RGS17 [plasma membrane] (R-HSA-939779)	0.556	3
UniProt:P27986-2 PIK3R1			0.556	3
UniProt:Q9UBQ0-2 VPS29			0.556	3
UniProt:Q8NE08 Q8NE08			0.556	3
UniProt:Q07954-2 LRP1			0.556	3
UniProt:P61158 ACTR3	1	ACTR3 [cytosol] (R-HSA-200811)	0.556	3
UniProt:O15269-2 O152692			0.556	3
UniProt:P51149 RAB7A	7	RAB7A [secretory granule membrane] (R-HSA-6804969) RAB7A [plasma membrane] (R-HSA-6804990) RAB7A [cytosol] (R-HSA-8870415) RAB7A [phagocytic vesicle membrane] (R-HSA-9636586) RAB7A [lysosomal membrane] (R-HSA-2213231) GGC-RAB7A [cytosol] (R-HSA-8870438) GGC-RAB7A [lysosomal membrane] (R-HSA-8877454)	0.556	3
UniProt:Q9BVN2 RUSC1			0.556	3
UniProt:O60260-5 PRKN			0.556	6
UniProt:Q9UQM7 CAMK2A	6	p-T286-CAMK2A [plasma membrane] (R-HSA-432796) p-T286-CAMK2A [nucleoplasm] (R-HSA-444797) p-T286-CAMK2A [endocytic vesicle membrane] (R-HSA-416999) p-T286,T305,T306-CAMK2A [cytosol] (R-HSA-4332334) CAMK2A [cytosol] (R-HSA-4332329) p-T286-CAMK2A [cytosol] (R-HSA-445368)	0.556	3
UniProt:P21964-2 COMT			0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:Q86WV8 Q86WV8			0.556	3
UniProt:Q8WXU2-2 DNAAF4			0.556	3
UniProt:P01011 SERPINA3	4	SERPINA3 [platelet alpha granule lumen] (R-HSA-8848913) SERPINA3 [secretory granule lumen] (R-HSA-6801018) SERPINA3 [extracellular region] (R-HSA-6806173) SERPINA3 [azurophil granule lumen] (R-HSA-6798754)	0.556	3
UniProt:Q14257 RCN2			0.556	3
UniProt:O00628-2 O006282			0.556	3
UniProt:Q8N5K1 CISD2			0.556	3
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.556	3
UniProt:P13591 NCAM1	2	6xN-linked glycan core-NCAM1 [Golgi membrane] (R-HSA-422430) NCAM1 [plasma membrane] (R-HSA-190987)	0.556	3
UniProt:P22466 GAL	1	GAL [extracellular region] (R-HSA-389038)	0.556	3
UniProt:P35240 NF2	1	NF2 [plasma membrane] (R-HSA-5669168)	0.556	3
UniProt:P08138 NGFR	7	NGFR [plasma membrane] (R-HSA-193664) NGFR(29-250) [extracellular region] (R-HSA-194470) NGFR(251-427) [plasma membrane] (R-HSA-194476) NGFR(251-427) [endosome] (R-HSA-209541) NGFR(273-427) [cytosol] (R-HSA-194458) NGFR(251-272) [plasma membrane] (R-HSA-194509) NGFR(273-427) [nucleoplasm] (R-HSA-197473)	0.556	3
UniProt:Q53GS7 GLE1	1	GLE1 [nucleoplasm] (R-HSA-8932905)	0.556	3
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.556	3
UniProt:P02545 LMNA	3	LMNA(1-646) [nuclear envelope] (R-HSA-535479) LMNA(1-567)-RAF1(279-648) fusion [cytosol] (R-HSA-6802399) LMNA(1-567)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802537)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:O75344 FKBP6	2	FKBP6 [nucleoplasm] (R-HSA-912512) FKBP6 [cytosol] (R-HSA-5601923)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	12
UniProt:P68036 UBE2L3	4	Ub-C86-UBE2L3 [nucleoplasm] (R-HSA-8864226) UBE2L3 [nucleoplasm] (R-HSA-8852056) Ub-C86-UBE2L3 [cytosol] (R-HSA-8864201) UBE2L3 [cytosol] (R-HSA-947631)	0.556	3
UniProt:P17612 PRKACA	3	PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [cytosol] (R-HSA-57844)	0.556	3
UniProt:A0AVK6 E2F8	1	E2F8 [nucleoplasm] (R-HSA-8952990)	0.556	3
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.556	3
UniProt:P52333 JAK3	6	p-Y980 JAK3 [cytosol] (R-HSA-9701438) p-Y904,939-JAK3 [plasma membrane] (R-HSA-8985978) JAK3 [endosome] (R-HSA-8983184) p-Y-JAK3 [cytosol] (R-HSA-9006854) p-JAK3 [cytosol] (R-HSA-8982856) JAK3 [cytosol] (R-HSA-451893)	0.527	2
UniProt:Q8IZL9 CDK20			0.527	2
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.527	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.527	3
UniProt:P51617 IRAK1	14	p-S376,T387-IRAK1 [cytosol] (R-HSA-446687) K63polyUb-hp-IRAK1 [endosome membrane] (R-HSA-975112) p-S,T-IRAK1 [cytosol] (R-HSA-3149574) K63polyUb-hp-IRAK1 [cytosol] (R-HSA-451565) p-T209-IRAK1 [endosome membrane] (R-HSA-975189) p-T209,T387-IRAK1 [endosome membrane] (R-HSA-975117) IRAK1 [endosome membrane] (R-HSA-975127) p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] (R-HSA-975157) IRAK1 [plasma membrane] (R-HSA-937045) p-T209-IRAK1 [plasma membrane] (R-HSA-937031) p-T209,T387-IRAK1 [plasma membrane] (R-HSA-166279) p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (R-HSA-937011) p-2S,S376,T,T209,T387-IRAK1 [cytosol] (R-HSA-446682) IRAK1 [cytosol] (R-HSA-446639)	0.527	2
UniProt:Q9Y2U5 M3K2			0.524	9
UniProt:P10636 MAPT	3	MAPT(422-758) [cytosol] (R-HSA-350642) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT [cytosol] (R-HSA-201574)	0.524	2
UniProt:Q96AP0 ACD	1	ACD [nucleoplasm] (R-HSA-174889)	0.508	2
UniProt:O95816 BAG2	1	BAG2 [cytosol] (R-HSA-5255445)	0.499	4
UniProt:Q99933 BAG1	1	BAG1 [cytosol] (R-HSA-5255443)	0.499	2
UniProt:P12504 VIF			0.499	2
UniProt:Q15773 MLF2			0.499	3

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