Reactome | INHBA [extracellular region]

INHBA [extracellular region]

Stable Identifier

R-HSA-205926

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Human Activin A chain, Human Activin A

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P08476 INHBA

Gene Names

INHBA

Chain

signal peptide:1-20, propeptide:21-310, chain:311-426

Reference Genes

BioGPS Gene:3624 INHBA

COSMIC (genes):INHBA INHBA

CTD Gene:3624 INHBA

dbSNP Gene:3624 INHBA

ENSEMBL:ENSG00000122641 INHBA

HGNC:6066 INHBA

KEGG:hsa:3624 INHBA

Monarch:3624 INHBA

NCBI Gene:3624 INHBA

OMIM:147290 INHBA

UCSC:P08476 INHBA

Reference Transcript

Other Identifiers

11731496_at

11746931_a_at

1203_at

17056980

17056984

204926_at

210511_PM_s_at

210511_s_at

227140_PM_at

227140_at

3047573

3047574

3047575

3047576

3047577

3047578

3047580

3047582

3047583

3047584

3047585

3047586

3047587

3047589

3047590

3047591

3047592

3047593

3047594

3047595

3047596

3047597

3047598

3047599

3047600

3047617

3047619

3047621

3624

40357_at

65626_at

8139207

A_23_P122924

A_24_P535256

D17357_at

GE57486

GE746940

GO:0001541

GO:0001707

GO:0001942

GO:0002244

GO:0005102

GO:0005125

GO:0005179

GO:0005515

GO:0005576

GO:0005615

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006629

GO:0006694

GO:0006914

GO:0006952

GO:0007166

GO:0007178

GO:0007267

GO:0007399

GO:0008083

GO:0008202

GO:0008209

GO:0008285

GO:0008584

GO:0010467

GO:0010628

GO:0017046

GO:0019221

GO:0021773

GO:0022414

GO:0030154

GO:0030218

GO:0030308

GO:0032689

GO:0032924

GO:0032967

GO:0035987

GO:0042326

GO:0042476

GO:0042541

GO:0042701

GO:0042802

GO:0043509

GO:0043512

GO:0044877

GO:0045578

GO:0045648

GO:0045650

GO:0045893

GO:0045944

GO:0045945

GO:0046880

GO:0046881

GO:0046882

GO:0048018

GO:0048333

GO:0048468

GO:0048471

GO:0048513

GO:0048731

GO:0048856

GO:0051247

GO:0051799

GO:0060008

GO:0060021

GO:0060279

GO:0060391

GO:0060395

GO:0060936

GO:0061029

GO:0061370

GO:0070374

GO:0070699

GO:0071372

GO:0071397

GO:0071456

GO:0090650

GO:0097154

GO:0097191

GO:0098772

GO:0150005

GO:1903449

GO:1904044

GO:1904385

GO:2000134

GO:2001241

HMNXSV003011526

HMNXSV003034371

Hs.28792.0.S1_3p_at

ILMN_1719547

PH_hs_0031121

TC07001317.hg

TC07001318.hg

TC07002911.hg

X57579_s_at

g186414_3p_a_at

g4504698_3p_at

p14920

Participates

as a member of

INHBs [extracellular region] (Homo sapiens)

as a component of

Inferred To

inhba [extracellular region] (Xenopus tropicalis)

Inhba [extracellular region] (Mus musculus)

Inhba [extracellular region] (Rattus norvegicus)

inhbaa [extracellular region] (Danio rerio)

INHBA [extracellular region] (Bos taurus)

INHBA [extracellular region] (Canis familiaris)

INHBA [extracellular region] (Gallus gallus)

INHBA [extracellular region] (Sus scrofa)

Actbeta [extracellular region] (Drosophila melanogaster)

Cross References

RefSeq

NP_002183.1, XP_016867663.2, XP_047276291.1, XP_016867665.1

OpenTargets

ENSG00000122641

ENSEMBL

ENSP00000242208, ENSP00000490646, ENSP00000397197, ENSG00000122641, ENST00000638023, ENST00000442711, ENST00000242208

HPA

ENSG00000122641-INHBA

GeneCards

INHBA

PRO

P08476

Pharos - Targets

P08476

Orphanet

INHBA

GlyGen

P08476

PDB

7OLY, 7U5P, 5HLZ, 5HLY, 2ARP, 2ARV, 2B0U, 3B4V, 2P6A, 4MID, 6Y6O, 1S4Y, 1NYS, 9I5W, 1NYU, 6Y6N

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21674	1	Fst [extracellular region] (R-RNO-2473211)	0.558	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.553	3
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.471	2