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HYAL2 [plasma membrane]
Stable Identifier
R-HSA-2160919
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Hyaluronidase-2, HYAL2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Hyaluronan metabolism (Homo sapiens)
Hyaluronan uptake and degradation (Homo sapiens)
HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Homo sapiens)
HA:HAR:HYAL2 [plasma membrane] (Homo sapiens)
HYAL2 [plasma membrane] (Homo sapiens)
HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+ [plasma membrane] (Homo sapiens)
HA:HAR:HYAL2 [plasma membrane] (Homo sapiens)
HYAL2 [plasma membrane] (Homo sapiens)
Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Homo sapiens)
HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+ [plasma membrane] (Homo sapiens)
HA:HAR:HYAL2 [plasma membrane] (Homo sapiens)
HYAL2 [plasma membrane] (Homo sapiens)
HYAL2 [plasma membrane] (Homo sapiens)
Receptor-mediated uptake of HA (Homo sapiens)
HA:HAR:HYAL2 [plasma membrane] (Homo sapiens)
HYAL2 [plasma membrane] (Homo sapiens)
HYAL2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q12891 HYAL2
Gene Names
HYAL2, LUCA2
Chain
signal peptide:1-20, chain:21-448, propeptide:449-473
Reference Genes
BioGPS Gene:8692 HYAL2
COSMIC (genes):HYAL2 HYAL2
CTD Gene:8692 HYAL2
dbSNP Gene:8692 HYAL2
ENSEMBL:ENSG00000068001 HYAL2
ENSEMBL_homo_sapiens_GENE:ENSG00000068001.14 HYAL2
HGNC:5321 HYAL2
KEGG Gene (Homo sapiens):8692 HYAL2
Monarch:8692 HYAL2
NCBI Gene:8692 HYAL2
OMIM:603551 HYAL2
UCSC:Q12891 HYAL2
Reference Transcript
RefSeq:XM_005265524.2 HYAL2
RefSeq:NM_003773.4 HYAL2
RefSeq:NM_033158.4 HYAL2
RefSeq:XM_005265525.2 HYAL2
Other Identifiers
11734759_x_at
16954416
206855_PM_s_at
206855_s_at
2675172
2675173
2675174
2675176
2675179
2675180
2675181
2675182
2675183
2675184
2675185
2675186
2675187
2675188
2675189
2675190
2675191
37042_at
38115_at
8087624
8692
AJ000099_s_at
A_23_P251562
A_23_P57927
A_33_P3365357
GE58905
GO:0000139
GO:0000302
GO:0001618
GO:0001822
GO:0002244
GO:0002376
GO:0003014
GO:0003713
GO:0003824
GO:0004415
GO:0005515
GO:0005540
GO:0005634
GO:0005737
GO:0005764
GO:0005773
GO:0005783
GO:0005794
GO:0005829
GO:0005886
GO:0005902
GO:0005975
GO:0006027
GO:0006351
GO:0006355
GO:0006886
GO:0006913
GO:0006954
GO:0008152
GO:0009615
GO:0009897
GO:0009986
GO:0010764
GO:0012501
GO:0016020
GO:0016324
GO:0016787
GO:0016798
GO:0019064
GO:0019899
GO:0023052
GO:0030139
GO:0030154
GO:0030214
GO:0030294
GO:0030308
GO:0030971
GO:0031410
GO:0032755
GO:0032757
GO:0033906
GO:0035810
GO:0036211
GO:0042117
GO:0042307
GO:0043226
GO:0043407
GO:0044344
GO:0045121
GO:0045944
GO:0046677
GO:0046718
GO:0048471
GO:0048705
GO:0048856
GO:0048870
GO:0050431
GO:0050729
GO:0051216
GO:0051607
GO:0051898
GO:0055065
GO:0060586
GO:0061024
GO:0061099
GO:0070295
GO:0071347
GO:0071356
GO:0071493
GO:0071560
GO:0090575
GO:0098542
GO:0098552
GO:0098772
GO:0140110
GO:1901135
GO:2001238
HMNXSV003029208
HMNXSV003030667
ILMN_1665916
ILMN_1668283
PH_hs_0004433
TC03002909.hg
TC03003329.hg
g4504550_3p_s_at
g6005759_3p_a_at
Participates
as an input of
Receptor-mediated uptake of HA (Homo sapiens)
as a component of
HA:HAR:HYAL2 [plasma membrane] (Homo sapiens)
Inferred To
HYAL2 [plasma membrane]
(Bos taurus)
HYAL2 [plasma membrane]
(Gallus gallus)
HYAL2 [plasma membrane]
(Sus scrofa)
Hyal2 [plasma membrane]
(Mus musculus)
Hyal2 [plasma membrane]
(Rattus norvegicus)
Ghost homologue of HYAL2 [plasma membrane]
(Canis familiaris)
Ghost homologue of HYAL2 [plasma membrane]
(Xenopus tropicalis)
chhy-1 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_003764.3
,
NP_149348.2
,
XP_005265581.1
,
XP_005265582.1
OpenTargets
ENSG00000068001
GeneCards
Q12891
HPA
ENSG00000068001-HYAL2
Ensembl
ENSP00000406657
,
ENST00000447092
,
ENSG00000068001
,
ENSP00000378571
,
ENST00000442581
,
ENSP00000401853
,
ENST00000395139
,
ENST00000357750
,
ENSP00000350387
PRO
Q12891
Pharos - Targets
Q12891
Orphanet
27163
HMDB Protein
HMDBP09374
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q3LI66 KRTAP6-2
1
KRTAP6-2 [cytosol]
(R-HSA-6810261)
0.556
3
UniProt:Q3LI67 KRTAP6-3
1
KRTAP6-3 [cytosol]
(R-HSA-6810281)
0.556
3
UniProt:P05067-2 APP
0.556
3
UniProt:O76011 KRT34
1
KRT34 [cytosol]
(R-HSA-6809608)
0.556
3
IntAct:EBI-10171679 386682
0.556
3
UniProt:Q07627 KRTAP1-1
1
KRTAP1-1 [cytosol]
(R-HSA-6809855)
0.556
3
UniProt:Q9UBB4 ATX10
0.556
3
UniProt:Q9BYR7 KRTAP3-2
1
KRTAP3-2 [cytosol]
(R-HSA-6809857)
0.556
3
UniProt:P49768-2 PSEN1
0.556
3
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
9
UniProt:P29474 NOS3
9
2xPalmC-MyrG-p-S1177,S1179-NOS3 [plasma membrane]
(R-HSA-9860783)
2xPalmC-MyrG-p-S633-NOS3 [plasma membrane]
(R-HSA-9861341)
2xPalmC-MyrG-NOS3 [endocytic vesicle membrane]
(R-HSA-535007)
2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane]
(R-HSA-202139)
MyrG-NOS3 [Golgi membrane]
(R-HSA-534995)
MyrG-NOS3 [cytosol]
(R-HSA-203687)
2xPalmC-MyrG-NOS3 [plasma membrane]
(R-HSA-534993)
2xPalmC-MyrG-NOS3 [Golgi membrane]
(R-HSA-203769)
NOS3 [cytosol]
(R-HSA-202114)
0.556
3
UniProt:Q13643 FHL3
0.556
3
UniProt:Q9HAT8 PELI2
2
PELI2 [cytosol]
(R-HSA-450694)
p-PELI2 [cytosol]
(R-HSA-450825)
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.556
3
UniProt:P16444 DPEP1
1
DPEP1 [plasma membrane]
(R-HSA-2142820)
0.527
3
UniProt:Q96GX1 TCTN2
1
TCTN2 [ciliary membrane]
(R-HSA-5626661)
0.527
2
UniProt:P21217 FUT3
1
FUT3 [Golgi membrane]
(R-HSA-5693934)
0.527
2
UniProt:Q6ZMH5 SLC39A5
1
SLC39A5 [plasma membrane]
(R-HSA-442360)
0.527
2
UniProt:Q15165 PON2
1
PON2 [extracellular region]
(R-HSA-8932636)
0.499
2
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