Reactome | RPN2 [endoplasmic reticulum membrane]

RPN2 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-264937

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        Late SARS-CoV-2 Infection Events (Homo sapiens)
        
        Translation of Structural Proteins (Homo sapiens)
        
        Maturation of spike protein (Homo sapiens)
        
        Spike protein gets N-glycosylated (Homo sapiens)
        
        OST complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        RPN2 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P04844 RPN2

Gene Names

RPN2

Chain

signal peptide:1-22, chain:23-631

Reference Genes

BioGPS Gene:6185 RPN2

COSMIC (genes):RPN2 RPN2

CTD Gene:6185 RPN2

dbSNP Gene:6185 RPN2

ENSEMBL:ENSG00000118705 RPN2

ENSEMBL_homo_sapiens_GENE:ENSG00000118705.18 RPN2

ENSEMBL_homo_sapiens_GENE:ENSG00000291973.1 RPN2

HGNC:10382 RPN2

KEGG Gene (Homo sapiens):6185 RPN2

Monarch:6185 RPN2

NCBI Gene:6185 RPN2

OMIM:180490 RPN2

UCSC:P04844 RPN2

Reference Transcript

Other Identifiers

11715660_a_at

16913378

208689_PM_s_at

208689_s_at

213399_PM_x_at

213399_x_at

213491_PM_x_at

213491_x_at

36676_at

3884102

3884103

3884105

3884108

3884110

3884117

3884118

3884119

3884120

3884121

3884123

3884124

3884129

3884130

3884134

3884136

3884137

3884138

3884143

3884146

3884147

3884148

3884149

6185

8062349

A_23_P108994

A_33_P3240258

A_33_P3332145

GE81214

GO:0003824

GO:0004579

GO:0005515

GO:0005634

GO:0005654

GO:0005783

GO:0005789

GO:0006486

GO:0006487

GO:0008250

GO:0016020

GO:0016604

GO:0016740

GO:0018279

GO:0036211

GO:0043226

GO:1901135

HMNXSV003027642

ILMN_1693421

TC20000271.hg

Y00282_at

g13097707_3p_a_at

Participates

as a component of

Cross References

RefSeq

NP_001311230.1, NP_001311228.1, NP_001311235.1, NP_001311232.1, NP_002942.2, NP_001311233.1, NP_001311231.1, NP_001129243.1, NP_001311234.1

OpenTargets

ENSG00000118705

HPA

ENSG00000118705-RPN2

GeneCards

P04844

Ensembl

ENSG00000118705, ENSP00000237530, ENSP00000362724, ENST00000237530, ENST00000373622

PRO

P04844

Pharos - Targets

P04844

PDB

6S7T, 8B6L, 6S7O

HMDB Protein

HMDBP01592

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14165 MLEC	3	MLEC [plasma membrane] (R-HSA-6806292) MLEC [specific granule membrane] (R-HSA-6799618) MLEC [endoplasmic reticulum membrane] (R-HSA-901082)	0.744	4
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.671	5
UniProt:Q9NZJ5 EIF2AK3	3	EIF2AK3 [endoplasmic reticulum membrane] (R-HSA-381046) EIF2AK3(30-144)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713456) EIF2AK3(30-144)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713454)	0.643	3
UniProt:P04114 APOB	20	APOB(28-2179) [cytosol] (R-HSA-2395786) APOB(28-2179) [early endosome] (R-HSA-2429651) APOB(28-4563) [lysosomal lumen] (R-HSA-8876369) APOB(28-2179) [endosome lumen] (R-HSA-174716) APOB(28-2179) [endosome membrane] (R-HSA-174762) APOB(28-4563) [plasma membrane] (R-HSA-171089) APOB(28-4563) [clathrin-coated endocytic vesicle membrane] (R-HSA-171155) APOB(28-4563) [endosome lumen] (R-HSA-171119) APOB(28-4563) [endosome membrane] (R-HSA-171121) APOB(28-2179) [clathrin-coated endocytic vesicle membrane] (R-HSA-174788) APOB(28-2179) [plasma membrane] (R-HSA-174625) APOB(28-2179) [endoplasmic reticulum lumen] (R-HSA-174620) APOB(28-2179) [extracellular region] (R-HSA-174770) APOB(28-2179) [endoplasmic reticulum membrane] (R-HSA-174637) APOB(28-4563) [smooth endoplasmic reticulum] (R-HSA-8866317) 10xdHF-10xglutamyl semialdehyde (Pro)-6xL-tyrosine residue-3xOxoH-2xmodified L-lysine residue-N'-formyl-L-kynurenine-APOB(28-4563) [endocytic vesicle lumen] (R-HSA-2239461) APOB(28-4563) [endocytic vesicle lumen] (R-HSA-2512789) AcK-APOB(28-4563) [endocytic vesicle lumen] (R-HSA-2239446) AcK-APOB(28-4563) [extracellular region] (R-HSA-2173751) p-APOB(28-4563) [endoplasmic reticulum lumen] (R-HSA-8957068)	0.527	2
UniProt:Q9Y3R4 NEU2	1	NEU2 [cytosol] (R-HSA-1605759)	0.527	2
UniProt:O60906 SMPD2	1	SMPD2 [plasma membrane] (R-HSA-194337)	0.527	2
UniProt:Q9H0U3 MAGT1	2	MAGT1 [azurophil granule membrane] (R-HSA-6799208) MAGT1 [plasma membrane] (R-HSA-4836523)	0.527	2
UniProt:Q13454 TUSC3	2	TUSC3(1-348) [plasma membrane] (R-HSA-5339529) TUSC3(1-348) [endoplasmic reticulum membrane] (R-HSA-532520)	0.527	3
UniProt:Q9H5K3 POMK	1	POMK [endoplasmic reticulum membrane] (R-HSA-8879120)	0.499	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	5
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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