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PANX1 [plasma membrane]
Stable Identifier
R-HSA-375344
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Pannexin-1, PANX1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes (Homo sapiens)
ATP binds P2RX7 in P2RX7 trimer:PANX1 heptamer (Homo sapiens)
ATP:P2X7 oligomer:PANX1 heptamer [plasma membrane] (Homo sapiens)
PANX1 heptamer [plasma membrane] (Homo sapiens)
PANX1 [plasma membrane] (Homo sapiens)
P2RX7 trimer:PANX1 heptamer [plasma membrane] (Homo sapiens)
PANX1 heptamer [plasma membrane] (Homo sapiens)
PANX1 [plasma membrane] (Homo sapiens)
P2RX7 in ATP:P2RX7:PANX1 transports cations from the extracellular region to the cytosol (Homo sapiens)
ATP:P2X7 oligomer:PANX1 heptamer [plasma membrane] (Homo sapiens)
PANX1 heptamer [plasma membrane] (Homo sapiens)
PANX1 [plasma membrane] (Homo sapiens)
Pannexin1 (PANX1) channel in a complex with P2RX7 transports ATP from the cytosol to the extracellular region (Homo sapiens)
P2RX7:PANX1,ATP:P2RX7:PANX1 [plasma membrane] (Homo sapiens)
ATP:P2X7 oligomer:PANX1 heptamer [plasma membrane] (Homo sapiens)
PANX1 heptamer [plasma membrane] (Homo sapiens)
PANX1 [plasma membrane] (Homo sapiens)
P2RX7 trimer:PANX1 heptamer [plasma membrane] (Homo sapiens)
PANX1 heptamer [plasma membrane] (Homo sapiens)
PANX1 [plasma membrane] (Homo sapiens)
PANX1 heptamer [plasma membrane] (Homo sapiens)
PANX1 [plasma membrane] (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
Pannexin-1 (PANX1) channel transports ATP from the cytosol to the extracellular region (Homo sapiens)
PANX1 heptamer [plasma membrane] (Homo sapiens)
PANX1 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
P2X7 mediates membrane pores that include pannexin-1 (Homo sapiens)
ATP:P2X7 oligomer:PANX1 heptamer [plasma membrane] (Homo sapiens)
PANX1 heptamer [plasma membrane] (Homo sapiens)
PANX1 [plasma membrane] (Homo sapiens)
PANX1 heptamer [plasma membrane] (Homo sapiens)
PANX1 [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Electrical Synapses (Homo sapiens)
Electric Transmission Across Gap Junctions (Homo sapiens)
Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Homo sapiens)
Pannexin 1/Pannexin 2 Gap Junction Complex [plasma membrane] (Homo sapiens)
Hemi-Pannexin 1 Complex [plasma membrane] (Homo sapiens)
PANX1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96RD7 PANX1
Gene Names
PANX1, MRS1, UNQ2529/PRO6028
Chain
chain:1-426, chain:1-379
Reference Genes
BioGPS Gene:24145 PANX1
COSMIC (genes):PANX1 PANX1
CTD Gene:24145 PANX1
dbSNP Gene:24145 PANX1
ENSEMBL:ENSG00000110218 PANX1
HGNC:8599 PANX1
KEGG:hsa:24145 PANX1
Monarch:24145 PANX1
NCBI Gene:24145 PANX1
OMIM:608420 PANX1
UCSC:Q96RD7 PANX1
Reference Transcript
RefSeq:NM_015368.3 PANX1
Other Identifiers
11719239_at
11719240_at
16730180
204715_PM_at
204715_at
24145
3344991
3344992
3345000
3345007
3345008
3345010
3345011
3345012
3345013
35623_at
51075_at
7943218
A_14_P113270
A_23_P47155
A_23_P52634
A_33_P3370404
GE54774
GO:0002020
GO:0002931
GO:0003779
GO:0005102
GO:0005198
GO:0005215
GO:0005243
GO:0005253
GO:0005262
GO:0005347
GO:0005515
GO:0005783
GO:0005789
GO:0005886
GO:0005921
GO:0006812
GO:0006816
GO:0007267
GO:0008092
GO:0015267
GO:0015867
GO:0016020
GO:0022414
GO:0022829
GO:0022840
GO:0023052
GO:0030154
GO:0032059
GO:0032730
GO:0032731
GO:0032732
GO:0032991
GO:0033198
GO:0042802
GO:0043226
GO:0044325
GO:0044877
GO:0048477
GO:0048856
GO:0051015
GO:0055085
GO:0060907
GO:0070588
GO:0097110
GO:0098656
HMNXSV003009634
ILMN_1697817
PH_hs_0022092
TC11000916.hg
g7662507_3p_at
Participates
as a component of
Hemi-Pannexin 1 Complex [plasma membrane] (Homo sapiens)
PANX1 heptamer [plasma membrane] (Homo sapiens)
Inferred To
Panx1 [plasma membrane]
(Mus musculus)
Panx1 [plasma membrane]
(Rattus norvegicus)
PANX1 [plasma membrane]
(Bos taurus)
PANX1 [plasma membrane]
(Canis familiaris)
PANX1 [plasma membrane]
(Gallus gallus)
PANX1 [plasma membrane]
(Sus scrofa)
panx1a [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_056183.2
Guide to Pharmacology - Targets
735
OpenTargets
ENSG00000110218
ENSEMBL
ENST00000436171
,
ENST00000227638
,
ENSP00000227638
,
ENSP00000411461
HPA
ENSG00000110218-PANX1
PRO
Q96RD7
Pharos - Targets
Q96RD7
Orphanet
PANX1
GlyGen
Q96RD7
PDB
7F8J
,
7WSV
,
6WBF
,
6LTN
,
6LTO
,
6WBL
,
6WBK
,
6WBI
,
6M66
,
6M67
,
6M68
,
6M02
,
6WBM
,
6WBN
,
7F8O
,
7F8N
,
6WBG
,
8GTS
,
8GYO
,
7DWB
,
6V6D
,
8GTT
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02652 APOA2
6
APOA2(24-100) [cytosol]
(R-HSA-2395772)
APOA2(24-100) [early endosome]
(R-HSA-2569092)
APOA2(24-100) [endoplasmic reticulum lumen]
(R-HSA-174689)
APOA2(24-100) [extracellular region]
(R-HSA-174775)
p-APOA2 [endoplasmic reticulum lumen]
(R-HSA-8957014)
APOA2 [endoplasmic reticulum lumen]
(R-HSA-8956780)
0.556
3
UniProt:P37268 FDFT1
1
FDFT1 [endoplasmic reticulum membrane]
(R-HSA-191369)
0.556
3
UniProt:Q14508 WFDC2
1
WFDC2 [extracellular region]
(R-HSA-9830363)
0.556
3
UniProt:P01375 TNF
5
TNF(1-233) [plasma membrane]
(R-HSA-66220)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(52-76) [extracellular region]
(R-HSA-8863375)
0.556
3
UniProt:Q9P296 C5AR2
1
C5AR2 [plasma membrane]
(R-HSA-964798)
0.527
2
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