Reactome | p-S544-DPYSL4 [cytosol]

p-S544-DPYSL4 [cytosol]

Stable Identifier

R-HSA-399808

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

pCRMP-3 (S544)

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Semaphorin interactions (Homo sapiens)
      - CRMPs in Sema3A signaling (Homo sapiens)
        
        Phosphorylation of CRMPs by Cdk5 (Homo sapiens)
        
        Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's [plasma membrane] (Homo sapiens)
        
        NRP1:PlexinA1-4:FYN:Cdk5:p53:p-CRMP tetramers [plasma membrane] (Homo sapiens)
        
        PlexinA1-4:FYN:Cdk5:p35:p-CRMP tetramers [plasma membrane] (Homo sapiens)
        
        p-CRMP tetramers [cytosol] (Homo sapiens)
        
        Cdk5 phosphorylated CRMP1-5 [cytosol] (Homo sapiens)
        
        p-S544-DPYSL4 [cytosol] (Homo sapiens)
        
        Phosphorylation of CRMPs by GSK3beta (Homo sapiens)
        
        Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's [plasma membrane] (Homo sapiens)
        
        NRP1:PlexinA1-4:FYN:Cdk5:p53:p-CRMP tetramers [plasma membrane] (Homo sapiens)
        
        PlexinA1-4:FYN:Cdk5:p35:p-CRMP tetramers [plasma membrane] (Homo sapiens)
        
        p-CRMP tetramers [cytosol] (Homo sapiens)
        
        Cdk5 phosphorylated CRMP1-5 [cytosol] (Homo sapiens)
        
        p-S544-DPYSL4 [cytosol] (Homo sapiens)

General

CRMP-3 does not have the conserved serine 522 and based on similarity serine 544 may be phosphorylated upon sema3A stimulation.

External Reference Information

External Reference

UniProt:O14531 DPYSL4

Gene Names

DPYSL4, CRMP3, ULIP4

Chain

chain:1-572

Reference Genes

BioGPS Gene:10570 DPYSL4

COSMIC (genes):DPYSL4 DPYSL4

CTD Gene:10570 DPYSL4

dbSNP Gene:10570 DPYSL4

ENSEMBL:ENSG00000151640 DPYSL4

HGNC:3016 DPYSL4

KEGG:hsa:10570 DPYSL4

Monarch:10570 DPYSL4

NCBI Gene:10570 DPYSL4

OMIM:608407 DPYSL4

UCSC:O14531 DPYSL4

Reference Transcript

RefSeq:NM_006426.2 DPYSL4

Other Identifiers

10570

11730332_at

11730333_at

16710720

205492_PM_s_at

205492_s_at

205493_PM_s_at

205493_s_at

3271916

3271917

3271918

3271921

3271922

3271923

3271924

3271926

3271927

3271928

3271929

3271930

3271933

3271934

3271936

3271938

3271940

3271941

3271942

3271943

3271944

3271945

3271946

3271947

3271948

3271949

39503_s_at

7931439

A_23_P331049

A_33_P3410296

GE53139

GO:0003824

GO:0005515

GO:0005737

GO:0005829

GO:0007399

GO:0008092

GO:0016787

GO:0016810

GO:0016812

GO:0031005

GO:0048856

HMNXSV003054638

Hs.100058.0.A1_3p_a_at

ILMN_1792356

PH_hs_0005598

TC10000941.hg

g11321616_3p_a_at

Participates

as a member of

Other forms of this molecule

p-Y-DPYSL4 [cytosol]

DPYSL4 [cytosol]

Inferred To

phospho-Dpysl4 [cytosol] (Mus musculus)

phospho-Dpysl4 [cytosol] (Rattus norvegicus)

phospho-DPYSL4 [cytosol] (Bos taurus)

phospho-DPYSL4 [cytosol] (Canis familiaris)

phospho-DPYSL4 [cytosol] (Sus scrofa)

phospho-unc-33 [cytosol] (Caenorhabditis elegans)

Homologues of p-S544-DPYSL4 [cytosol] (Caenorhabditis elegans)

phospho-p-S544-DPYSL4 [cytosol] (Caenorhabditis elegans)

phospho-p-S544-DPYSL4 [cytosol] (Gallus gallus)

phospho-CRMP [cytosol] (Drosophila melanogaster)

Modified Residues

Name

O-phospho-L-serine at 544

Coordinate

544

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_006417.2

ENSEMBL

ENST00000338492, ENSP00000339850

OpenTargets

ENSG00000151640

HPA

ENSG00000151640-DPYSL4

PRO

O14531

Pharos - Targets

O14531

GlyGen

O14531

PDB

5NKS

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 [plasma membrane] (R-HSA-170842) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905)	0.556	3
UniProt:P17612 PRKACA	4	PRKACA [cytosol] (R-HSA-57844) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [mitochondrial matrix] (R-HSA-9838291)	0.556	3
UniProt:Q13309 SKP2	3	SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [cytosol] (R-HSA-975495)	0.527	2
UniProt:Q9BQ90 KLHDC3	1	KLHDC3 [cytosol] (R-HSA-535552)	0.527	2