Reactome | SKP2 [nucleoplasm]

SKP2 [nucleoplasm]

Stable Identifier

R-HSA-975554

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

S-phase kinase-associated protein 2, SKP2_HUMAN

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Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP13 binds UFD1L:SKP2 (Homo sapiens)
        
        UFD1L:SKP2 [nucleoplasm] (Homo sapiens)
        
        SKP2 [nucleoplasm] (Homo sapiens)
        
        USP13:UFD1L:SKP2 [nucleoplasm] (Homo sapiens)
        
        UFD1L:SKP2 [nucleoplasm] (Homo sapiens)
        
        SKP2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13309 SKP2

Gene Names

SKP2, FBXL1

Chain

chain:1-424

Reference Genes

BioGPS Gene:6502 SKP2

COSMIC (genes):SKP2 SKP2

CTD Gene:6502 SKP2

dbSNP Gene:6502 SKP2

ENSEMBL:ENSG00000145604 SKP2

HGNC:10901 SKP2

KEGG:hsa:6502 SKP2

Monarch:6502 SKP2

NCBI Gene:6502 SKP2

OMIM:601436 SKP2

UCSC:Q13309 SKP2

Reference Transcript

Participates

as a component of

as an input of

Other forms of this molecule

PolyUb-SKP2 [nucleoplasm]

SKP2 [cytosol]

Inferred To

Skp2 [nucleoplasm] (Drosophila melanogaster)

Skp2 [nucleoplasm] (Mus musculus)

Skp2 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of SKP2 [nucleoplasm] (Canis familiaris)

Ghost homologue of SKP2 [nucleoplasm] (Danio rerio)

Ghost homologue of SKP2 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of SKP2 [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of SKP2 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of SKP2 [nucleoplasm] (Schizosaccharomyces pombe)

Ghost homologue of SKP2 [nucleoplasm] (Xenopus tropicalis)

SKP2 [nucleoplasm] (Bos taurus)

SKP2 [nucleoplasm] (Gallus gallus)

SKP2 [nucleoplasm] (Sus scrofa)

skpt-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_116026.1, NP_001230049.1, NP_005974.2

Guide to Pharmacology - Targets

3235

OpenTargets

ENSG00000145604

ENSEMBL

ENSP00000274255, ENSP00000274254, ENSG00000145604, ENST00000274255, ENST00000274254

GeneCards

SKP2

HPA

ENSG00000145604-SKP2

PRO

Q13309

Pharos - Targets

Q13309

PDB

1FQV, 7Z8V, 7Z8T, 8BYL, 7B5R, 7B5M, 7B5L, 7LUO, 7ZBW, 7ZBZ, 8CDK, 8CDJ, 1FS1, 1FS2, 8BYA, 8OR3, 2AST, 2ASS, 8OR0, 1LDK, 8OR4

Interactors (49)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.955	19
UniProt:P24941 CDK2	5	p-T160-CDK2 [nucleoplasm] (R-HSA-187967) CDK2 [nucleoplasm] (R-HSA-68365) CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905)	0.903	13
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.858	9
UniProt:Q13616 CUL1	3	CUL1 [cytosol] (R-HSA-174230) CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519)	0.823	15
UniProt:P46527 CDKN1B	8	p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.75	4
UniProt:P38936 CDKN1A	5	CDKN1A [nucleoplasm] (R-HSA-182585) CDKN1A [cytosol] (R-HSA-182512) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) p-T145-CDKN1A [cytosol] (R-HSA-198614)	0.731	4
UniProt:P06493 CDK1	11	p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) CDK1 [cytosol] (R-HSA-170075) CDK1 [nucleoplasm] (R-HSA-68889) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-Y4-CDK1 [cytosol] (R-HSA-9836187) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424)	0.725	6
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.725	7
UniProt:P20248 CCNA2	5	p-S154-CCNA2 [nucleoplasm] (R-HSA-9929512) p-S154-CCNA2 [cytosol] (R-HSA-9929551) CCNA2 [nucleoplasm] (R-HSA-68905) CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099)	0.725	6
UniProt:Q9UM11 FZR1	5	FZR1 [cytosol] (R-HSA-174249) FZR1 [nucleoplasm] (R-HSA-174099) p-FZR1 [nucleoplasm] (R-HSA-174257) p-FZR1 [cytosol] (R-HSA-174193) p-S151-FZR1 [nucleoplasm] (R-HSA-9929805)	0.669	5
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.643	4
UniProt:Q00526 CDK3			0.643	4
UniProt:Q8N5M4 TTC9C			0.643	5
UniProt:P62877 RBX1	2	RBX1 [nucleoplasm] (R-HSA-1234142) RBX1 [cytosol] (R-HSA-180582)	0.623	4
UniProt:P11440 Cdk1	11	phospho-Cdk1 [nucleoplasm] (R-MMU-170066) phospho-Cdk1 [nucleoplasm] (R-MMU-170074) phospho-Cdk1 [cytosol] (R-MMU-157415) phospho-Cdk1 [cytosol] (R-MMU-170071) Cdk1 [cytosol] (R-MMU-170075) Cdk1 [nucleoplasm] (R-MMU-1362302) phospho-Cdk1 [nucleoplasm] (R-MMU-170078) phospho-Cdk1 [nucleoplasm] (R-MMU-170045) phospho-Cdk1 [cytosol] (R-MMU-170064) phospho-Cdk1 [cytosol] (R-MMU-9836187) Cdk1 [endoplasmic reticulum membrane] (R-MMU-264424)	0.623	4
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.596	4
UniProt:Q13309 SKP2	3	SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [cytosol] (R-HSA-975495)	0.591	3
UniProt:Q9NTG7 SIRT3	2	SIRT3(?-399) [mitochondrial matrix] (R-HSA-1605416) SIRT3 [nucleoplasm] (R-HSA-9622879)	0.576	5
UniProt:P28562 DUSP1	1	DUSP1 [nucleoplasm] (R-HSA-203796)	0.576	3
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.536	5
UniProt:Q6DN90 IQEC1			0.527	3
UniProt:Q9H9A6 LRC40			0.527	3
UniProt:P31321 PRKAR1B	2	PRKAR1B [cytosol] (R-HSA-57838) PRKAR1B [ciliary base] (R-HSA-5610409)	0.527	2
UniProt:Q2VPB7 AP5B1			0.527	3
UniProt:Q5VUJ6 LRCH2			0.527	2
UniProt:Q9H1A4 ANAPC1	2	ANAPC1 [cytosol] (R-HSA-174189) ANAPC1 [nucleoplasm] (R-HSA-174217)	0.527	3
UniProt:O75496 GMNN	2	GMNN [nucleoplasm] (R-HSA-113554) PolyUb-GMNN [nucleoplasm] (R-HSA-68585)	0.527	2
UniProt:Q13188 STK3	4	STK3(1-491) [cytosol] (R-HSA-2028280) p-T180-STK3(1-491) [cytosol] (R-HSA-2028274) STK3(323-491) [cytosol] (R-HSA-2028684) p-T180-STK3(1-322) [cytosol] (R-HSA-2028696)	0.527	2
UniProt:Q9Y2Z0 SUGT1	1	SUGT1 [cytosol] (R-HSA-874107)	0.527	3
UniProt:Q92905 COPS5	3	CSN5 [cytosol] (R-HSA-9929354) COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.527	3
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070) Ub-105-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783103) Ub-27-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783038) Ub-179-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783114)	0.527	2
UniProt:Q9H211 CDT1	1	CDT1 [nucleoplasm] (R-HSA-68536)	0.527	2
UniProt:Q6SPF0 SAMD1			0.527	3
UniProt:Q9BV68 RNF126	1	RNF126 [cytosol] (R-HSA-8851642)	0.527	2
UniProt:Q6ZRV2 FA83H			0.527	3
UniProt:Q2TAL5 SMTL2			0.527	3
UniProt:P20839 IMPDH1	5	IMPDH1 [cytosol] (R-HSA-57348) IMPDH1 [azurophil granule lumen] (R-HSA-6799173) IMPDH1 [extracellular region] (R-HSA-6806182) IMPDH1 [secretory granule lumen] (R-HSA-6800971) IMPDH1 [ficolin-1-rich granule lumen] (R-HSA-6800927)	0.527	4
UniProt:P12268 IMPDH2	4	IMPDH2 [cytosol] (R-HSA-57350) IMPDH2 [secretory granule lumen] (R-HSA-6803323) IMPDH2 [extracellular region] (R-HSA-6806455) IMPDH2 [ficolin-1-rich granule lumen] (R-HSA-6803330)	0.527	2
UniProt:Q9UBW8 COPS7A	2	COPS7A [nucleoplasm] (R-HSA-5697011) COPS7A [cytosol] (R-HSA-416964)	0.527	2
UniProt:Q6PJI9 WDR59	1	WDR59 [lysosomal membrane] (R-HSA-9638236)	0.527	3
UniProt:Q9BZL6 PRKD2	1	PRKD2 [cytosol] (R-HSA-58214)	0.527	2
UniProt:Q13257 MAD2L1	2	MAD2L1 [cytosol] (R-HSA-141400) Activated MAD2L1 [cytosol] (R-HSA-141447)	0.527	2
UniProt:Q96BY7 ATG2B			0.527	2
UniProt:O14531 DPYSL4	3	p-Y-DPYSL4 [cytosol] (R-HSA-399794) p-S544-DPYSL4 [cytosol] (R-HSA-399808) DPYSL4 [cytosol] (R-HSA-398126)	0.527	2
UniProt:P0CI25 TRI49			0.527	2
UniProt:Q13415 ORC1	5	ORC1 [nucleoplasm] (R-HSA-68522) ORC1 [cytosol] (R-HSA-113840) p-S,T-ORC1 [nucleoplasm] (R-HSA-68943) PolyUb,p-S,T-ORC1 [nucleoplasm] (R-HSA-9032189) PolyUb,p-S,T-ORC1 [cytosol] (R-HSA-9032195)	0.524	2
UniProt:Q4AE16 Q4AE16			0.524	3
UniProt:P09803 Cdh1	20	Cdh1 [plasma membrane] (R-MMU-2534244) Cdh1 [extracellular region] (R-MMU-2534158) Cdh1(157-884) [plasma membrane] (R-MMU-199081) phospho-Cdh1 [plasma membrane] (R-MMU-9934660) phospho-Cdh1 [early endosome membrane] (R-MMU-9934659) phospho-Cdh1 [plasma membrane] (R-MMU-9935242) phospho-Cdh1 [early endosome membrane] (R-MMU-9935416) phospho-Cdh1 [lysosomal membrane] (R-MMU-9935544) phospho-Cdh1 [plasma membrane] (R-MMU-9934836) Cdh1 [plasma membrane] (R-MMU-198003) Cdh1 [plasma membrane] (R-MMU-202929) Cdh1 [plasma membrane] (R-MMU-202940) Cdh1 [endoplasmic reticulum membrane] (R-MMU-9932354) Cdh1 [endoplasmic reticulum membrane] (R-MMU-9933097) Cdh1 [endoplasmic reticulum membrane] (R-MMU-9932915) Cdh1 [endoplasmic reticulum membrane] (R-MMU-9932341) Cdh1 [endoplasmic reticulum membrane] (R-MMU-9932178) Cdh1 [endoplasmic reticulum membrane] (R-MMU-9932157) Cdh1 [endoplasmic reticulum membrane] (R-MMU-9816039) Cdh1 [endoplasmic reticulum lumen] (R-MMU-9932158)	0.524	2
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.524	3

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