Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
polySUMO2,3-K231,K294-SAFB [nucleoplasm]
Stable Identifier
R-HSA-4085357
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Scaffold attachment factor B1, SAFB1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
PIAS1 SUMOylates SAFB with SUMO2,3 (Homo sapiens)
polySUMO2,3-K231,K294-SAFB [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15424 SAFB
Gene Names
SAFB, HAP, HET, SAFB1
Chain
initiator methionine:, chain:2-915
Reference Genes
BioGPS Gene:6294 SAFB
COSMIC (genes):SAFB SAFB
CTD Gene:6294 SAFB
dbSNP Gene:6294 SAFB
ENSEMBL:ENSG00000160633 SAFB
ENSEMBL_homo_sapiens_GENE:ENSG00000160633.13 SAFB
HGNC:10520 SAFB
KEGG Gene (Homo sapiens):6294 SAFB
Monarch:6294 SAFB
NCBI Gene:6294 SAFB
OMIM:602895 SAFB
UCSC:Q15424 SAFB
Reference Transcript
RefSeq:NM_001320571.1 SAFB
RefSeq:NM_001320572.1 SAFB
RefSeq:NM_001201339.1 SAFB
RefSeq:NM_001201338.1 SAFB
RefSeq:NM_002967.3 SAFB
RefSeq:NM_001201340.1 SAFB
Other Identifiers
11722360_a_at
11747271_a_at
11756438_a_at
16857315
201747_PM_s_at
201747_s_at
201748_PM_s_at
201748_s_at
3353332
3817985
3817986
3817987
3817990
3817993
3817994
3817995
3817997
3818000
3818001
3818002
3818004
3818005
3818006
3818010
3818011
3818012
3818013
3818014
3818017
3818018
3818021
3818022
3818027
3818029
3818031
3818033
3818034
3847290
3847291
41316_s_at
6294
8024936
A_14_P124343
A_33_P3220818
GE61262
GO:0000978
GO:0003676
GO:0003677
GO:0003682
GO:0003690
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0006325
GO:0006351
GO:0006355
GO:0006357
GO:0016071
GO:0023052
GO:0030496
GO:0030520
GO:0043226
GO:0043565
GO:0050684
HMNXSV003053663
Hs.23978.0.S1_3p_a_at
ILMN_1722059
L43631_at
TC19000102.hg
TC19001950.hg
g4506778_3p_a_at
Participates
as an output of
PIAS1 SUMOylates SAFB with SUMO2,3 (Homo sapiens)
Other forms of this molecule
SAFB [nucleoplasm]
monoSUMO1-K231,K294-SAFB [nucleoplasm]
Inferred To
Safb [nucleoplasm]
(Mus musculus)
Safb [nucleoplasm]
(Rattus norvegicus)
Homologues of polySUMO2,3-K231,K294-SAFB [nucleoplasm]
(Gallus gallus)
safb [nucleoplasm]
(Danio rerio)
SAFB [nucleoplasm]
(Bos taurus)
SAFB [nucleoplasm]
(Gallus gallus)
SAFB [nucleoplasm]
(Sus scrofa)
Saf-B [nucleoplasm]
(Drosophila melanogaster)
polySUMO2,3-K231,K294-SAFB [nucleoplasm]
(Gallus gallus)
Modified Residues
Name
sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 231
Coordinate
231
Modification
polySUMO2,3 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 294
Coordinate
294
Modification
polySUMO2,3 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_002958.2
,
NP_001188267.1
,
NP_001307501.1
,
NP_001188269.1
,
NP_001307500.1
,
NP_001188268.1
OpenTargets
ENSG00000160633
HPA
ENSG00000160633-SAFB
GeneCards
Q15424
Ensembl
ENST00000454510
,
ENSG00000160633
,
ENST00000292123
,
ENST00000592224
,
ENSP00000464840
,
ENST00000588852
,
ENSP00000415895
,
ENSP00000292123
,
ENSP00000467423
PRO
Q15424
Pharos - Targets
Q15424
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35637 FUS
1
FUS [nucleoplasm]
(R-HSA-72040)
0.727
8
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.556
5
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [cytosol]
(R-HSA-5205651)
0.547
3
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
5
UniProt:Q96SB4-3 SRPK1
0.524
2
UniProt:Q96SB4-2 SRPK1
0.524
2
UniProt:Q14151 SAFB2
0.508
3
UniProt:Q9JKL7 SREK1
0.499
3
UniProt:P09651 HNRNPA1
2
HNRNPA1 [cytosol]
(R-HSA-9727902)
HNRNPA1 [nucleoplasm]
(R-HSA-71927)
0.483
2
UniProt:Q16630 CPSF6
2
CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol]
(R-HSA-1838987)
CPSF6(1-490)-FGFR1(429-822) fusion [cytosol]
(R-HSA-1614368)
0.483
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text