Reactome | EXOSC4 [cytosol]

EXOSC4 [cytosol]

Stable Identifier

R-HSA-430013

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Exosome complex exonuclease RRP41, EXOS4_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Unfolded Protein Response (UPR) (Homo sapiens)
    - PERK regulates gene expression (Homo sapiens)
      - ATF4 activates genes in response to endoplasmic reticulum stress (Homo sapiens)
        
        Expression of IL-8 (Homo sapiens)
        
        KSRP:mRNA Degradation Complex [cytosol] (Homo sapiens)
        
        Exosome Complex [cytosol] (Homo sapiens)
        
        Exosome Ring Hexamer [cytosol] (Homo sapiens)
        
        EXOSC4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NPD3 EXOSC4

Gene Names

EXOSC4, RRP41, SKI6

Chain

initiator methionine:, chain:2-245

Reference Genes

BioGPS Gene:54512 EXOSC4

COSMIC (genes):EXOSC4 EXOSC4

CTD Gene:54512 EXOSC4

dbSNP Gene:54512 EXOSC4

ENSEMBL:ENSG00000178896 EXOSC4

HGNC:18189 EXOSC4

KEGG:hsa:54512 EXOSC4

Monarch:54512 EXOSC4

NCBI Gene:54512 EXOSC4

OMIM:606491 EXOSC4

UCSC:Q9NPD3 EXOSC4

Reference Transcript

RefSeq:NM_019037.2 EXOSC4

Other Identifiers

11720077_at

17073527

218695_PM_at

218695_at

3120009

3120010

3120012

3120013

3120014

3120015

3120016

3120017

3120018

3120020

54512

58696_PM_at

58696_at

8148710

91684_PM_g_at

91684_g_at

A_23_P32463

A_33_P3301410

GE55565

GO:0000175

GO:0000176

GO:0000177

GO:0000178

GO:0000460

GO:0000791

GO:0000956

GO:0003723

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0006364

GO:0006396

GO:0006401

GO:0016071

GO:0016073

GO:0016075

GO:0016787

GO:0030307

GO:0034475

GO:0035925

GO:0043226

GO:0043231

GO:0045006

GO:0051607

GO:0071028

GO:0071044

GO:0071051

GO:0098542

GO:0101019

GO:0140098

GO:1902494

HMNXSV003004767

HMNXSV003025819

ILMN_1745271

PH_hs_0016640

PH_hs_0032744

TC08000838.hg

g9506688_3p_at

g9506688_3p_s_at

Participates

as a component of

Exosome Ring Hexamer [cytosol] (Homo sapiens)

Other forms of this molecule

EXOSC4 [nucleoplasm]

Inferred To

exosc4 [cytosol] (Xenopus tropicalis)

ski6 [cytosol] (Schizosaccharomyces pombe)

SKI6 [cytosol] (Saccharomyces cerevisiae)

Exosc4 [cytosol] (Mus musculus)

Exosc4 [cytosol] (Rattus norvegicus)

EXOSC4 [cytosol] (Bos taurus)

EXOSC4 [cytosol] (Canis familiaris)

EXOSC4 [cytosol] (Dictyostelium discoideum)

EXOSC4 [cytosol] (Sus scrofa)

Ski6 [cytosol] (Drosophila melanogaster)

exos-4.1 [cytosol] (Caenorhabditis elegans)

Ghost homologue of EXOSC4 [cytosol] (Gallus gallus)

Cross References

RefSeq

NP_061910.1

ENSEMBL

ENST00000316052, ENSP00000315476

OpenTargets

ENSG00000178896

HPA

ENSG00000178896-EXOSC4

PRO

Q9NPD3

Pharos - Targets

Q9NPD3

GlyGen

Q9NPD3

PDB

6D6Q, 6H25, 2NN6, 6D6R

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q01780 EXOSC10	1	EXOSC10 [nucleoplasm] (R-HSA-6791547)	0.845	7
UniProt:Q9NQT4 EXOSC5	2	EXOSC5 [cytosol] (R-HSA-429889) EXOSC5 [nucleoplasm] (R-HSA-6791550)	0.725	6
UniProt:Q99547 MPHOSPH6	1	MPHOSPH6 [nucleoplasm] (R-HSA-6791553)	0.643	5
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.556	3
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	3
UniProt:Q13901 C1D	1	C1D [nucleoplasm] (R-HSA-6791515)	0.527	3
UniProt:P42285 SKIV2L2	1	SKIV2L2 [nucleoplasm] (R-HSA-6791189)	0.527	3
UniProt:Q9Y2L1 DIS3	2	DIS3 [nucleoplasm] (R-HSA-6791517) DIS3 [cytosol] (R-HSA-429935)	0.462	2