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KLF4 [nucleoplasm]
Stable Identifier
R-HSA-434463
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Krueppel-like factor 4, KLF4_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of CEBPB in adipogenesis (Homo sapiens)
KLF4 [nucleoplasm] (Homo sapiens)
Transcriptional regulation of pluripotent stem cells (Homo sapiens)
Expression of NANOG (Homo sapiens)
KLF4 [nucleoplasm] (Homo sapiens)
POU5F1:SOX2:NANOG:KLF4:PBX1:SMAD2:FOXP1-ES:NANOG gene [nucleoplasm] (Homo sapiens)
KLF4 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter (Homo sapiens)
KLF4 [nucleoplasm] (Homo sapiens)
POU5F1:SOX2:NANOG:KLF4:PBX1:SMAD2:FOXP1-ES:NANOG gene [nucleoplasm] (Homo sapiens)
KLF4 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of cell cycle genes (Homo sapiens)
KLF4 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)
KLF4 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Synthesis, secretion, and deacylation of Ghrelin (Homo sapiens)
Expression of Preproghrelin (Homo sapiens)
KLF4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43474 KLF4
Gene Names
KLF4, EZF, GKLF
Chain
chain:1-513
Reference Genes
BioGPS Gene:9314 KLF4
COSMIC (genes):KLF4 KLF4
CTD Gene:9314 KLF4
dbSNP Gene:9314 KLF4
ENSEMBL:ENSG00000136826 KLF4
HGNC:6348 KLF4
KEGG:hsa:9314 KLF4
Monarch:9314 KLF4
NCBI Gene:9314 KLF4
OMIM:602253 KLF4
UCSC:O43474 KLF4
Reference Transcript
RefSeq:NM_004235.5 KLF4
RefSeq:NM_001314052.1 KLF4
Other Identifiers
11719633_a_at
11719634_a_at
17096827
220266_PM_s_at
220266_s_at
221841_PM_s_at
221841_s_at
3219225
3219226
3219227
3219228
3219229
3219230
3219232
3219233
3219234
3219235
3219236
3219237
3219238
3219239
3219240
3219241
3219242
3219243
36214_at
48587_at
8163002
9314
A_23_P32233
GE86000
GE86001
GO:0000122
GO:0000785
GO:0000791
GO:0000976
GO:0000978
GO:0000981
GO:0001010
GO:0001221
GO:0001228
GO:0002067
GO:0002357
GO:0003677
GO:0003690
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0005829
GO:0005856
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0007500
GO:0008013
GO:0008270
GO:0008285
GO:0008544
GO:0009913
GO:0010467
GO:0010628
GO:0010629
GO:0015630
GO:0016525
GO:0019827
GO:0030154
GO:0030336
GO:0031077
GO:0031490
GO:0032206
GO:0032526
GO:0032717
GO:0034115
GO:0035019
GO:0035166
GO:0042127
GO:0042826
GO:0043124
GO:0043226
GO:0043565
GO:0045429
GO:0045444
GO:0045595
GO:0045892
GO:0045893
GO:0045944
GO:0046872
GO:0046985
GO:0048662
GO:0048679
GO:0048730
GO:0048856
GO:0050728
GO:0051247
GO:0060070
GO:0060090
GO:0060761
GO:0061436
GO:0061629
GO:0070301
GO:0071300
GO:0071363
GO:0071407
GO:0071409
GO:0071499
GO:0090051
GO:0120222
GO:0140110
GO:1901653
GO:1902895
GO:1903672
GO:1904998
GO:1990830
GO:1990837
GO:1990841
GO:2000134
GO:2000342
GO:2001240
HMNXSV003055343
ILMN_1779857
ILMN_2137789
PH_hs_0032978
TC09001447.hg
U70663_at
g4758321_3p_a_at
Participates
as an output of
KLF4 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)
as an input of
POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter (Homo sapiens)
as a component of
POU5F1:SOX2:NANOG:KLF4:PBX1:SMAD2:FOXP1-ES:NANOG gene [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
Expression of CEBPB in adipogenesis
(Homo sapiens)
Expression of Preproghrelin
(Homo sapiens)
Inferred To
KLF4 [nucleoplasm]
(Bos taurus)
KLF4 [nucleoplasm]
(Canis familiaris)
KLF4 [nucleoplasm]
(Gallus gallus)
KLF4 [nucleoplasm]
(Sus scrofa)
klf4 [nucleoplasm]
(Xenopus tropicalis)
klf17 [nucleoplasm]
(Danio rerio)
CRZ1 [nucleoplasm]
(Saccharomyces cerevisiae)
Klf4 [nucleoplasm]
(Mus musculus)
Klf4 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_001300981.1
,
NP_004226.3
ENSEMBL
ENST00000374672
,
ENSP00000363804
OpenTargets
ENSG00000136826
HPA
ENSG00000136826-KLF4
PRO
O43474
Pharos - Targets
O43474
GlyGen
O43474
PDB
6VTX
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75031 HSF2B
0.556
3
UniProt:Q96JP2 MY15B
0.556
3
UniProt:P13807 GYS1
3
p-S-GYS1 [cytosol]
(R-HSA-71570)
GYS1 [cytosol]
(R-HSA-71565)
GYS1 R462* [cytosol]
(R-HSA-3828056)
0.556
5
UniProt:Q08117-2 TLE5
0.556
3
UniProt:Q92997 DVL3
4
pp-DVL3 [cytosol]
(R-HSA-3772400)
p-DVL3 [cytosol]
(R-HSA-201680)
DVL3 [cytosol]
(R-HSA-201678)
ub-DVL3 [cytosol]
(R-HSA-4652688)
0.556
3
UniProt:P55771 PAX9
0.556
3
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.556
3
IntAct:EBI-11177518 CD14
0.544
2
IntAct:EBI-11177705 CD14
0.544
2
UniProt:O15550 KDM6A
1
KDM6A [nucleoplasm]
(R-HSA-4754224)
0.536
2
UniProt:Q13363 CTBP1
3
CTBP1 [nucleoplasm]
(R-HSA-212372)
polySUMO2,3-K428-CTBP1 [nucleoplasm]
(R-HSA-3108226)
monoSUMO1-K428-CTBP1 [nucleoplasm]
(R-HSA-3108200)
0.524
4
UniProt:O95983 MBD3
1
MBD3 [nucleoplasm]
(R-HSA-4657010)
0.499
3
UniProt:P10275 AR
4
AR [cytosol]
(R-HSA-5618082)
AR [nucleoplasm]
(R-HSA-446174)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
0.471
2
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