Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-DVL3 [cytosol]
Stable Identifier
R-HSA-201680
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
phospho-Dvl-3
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Killing mechanisms (Homo sapiens)
WNT5:FZD7-mediated leishmania damping (Homo sapiens)
Unknown kinase phosphorylates p-DVL (Homo sapiens)
WNT5:FZD7:p-DVL [plasma membrane] (Homo sapiens)
p-DVL [cytosol] (Homo sapiens)
p-DVL3 [cytosol] (Homo sapiens)
WNT5:FZD7 binds p-DVL (Homo sapiens)
WNT5:FZD7:p-DVL [plasma membrane] (Homo sapiens)
p-DVL [cytosol] (Homo sapiens)
p-DVL3 [cytosol] (Homo sapiens)
p-DVL [cytosol] (Homo sapiens)
p-DVL3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
DVL is recruited to the receptor (Homo sapiens)
WNT:FZD:pDVL [plasma membrane] (Homo sapiens)
p-DVL [cytosol] (Homo sapiens)
p-DVL3 [cytosol] (Homo sapiens)
p-DVL [cytosol] (Homo sapiens)
p-DVL3 [cytosol] (Homo sapiens)
WNT-dependent phosphorylation of DVL (Homo sapiens)
WNT:FZD:pDVL [plasma membrane] (Homo sapiens)
p-DVL [cytosol] (Homo sapiens)
p-DVL3 [cytosol] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
WNT mediated activation of DVL (Homo sapiens)
CSNK2-mediated phosphorylation of DVL (Homo sapiens)
p-DVL [cytosol] (Homo sapiens)
p-DVL3 [cytosol] (Homo sapiens)
WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Homo sapiens)
p-DVL [cytosol] (Homo sapiens)
p-DVL3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92997 DVL3
Gene Names
DVL3, KIAA0208
Chain
chain:1-716
Reference Genes
BioGPS Gene:1857 DVL3
COSMIC (genes):DVL3 DVL3
CTD Gene:1857 DVL3
dbSNP Gene:1857 DVL3
ENSEMBL:ENSG00000161202 DVL3
ENSEMBL_homo_sapiens_GENE:ENSG00000161202.20 DVL3
HGNC:3087 DVL3
KEGG Gene (Homo sapiens):1857 DVL3
Monarch:1857 DVL3
NCBI Gene:1857 DVL3
OMIM:601368 DVL3
UCSC:Q92997 DVL3
Reference Transcript
RefSeq:NM_004423.3 DVL3
Other Identifiers
11721506_a_at
11721507_at
11721508_at
11748468_a_at
16948712
1857
201907_PM_x_at
201908_PM_at
201908_at
2655439
2655440
2655441
2655444
2655445
2655446
2655448
2655452
2655453
2655454
2655455
2655458
2655459
2655461
2655462
2655463
2655466
2655467
2655468
2655469
2655470
2655471
2655472
2655473
2655474
2655475
2655477
2655478
40873_at
43731_at
8084323
A_14_P135109
A_23_P218884
A_24_P283000
A_24_P291588
D86963_at
GE58335
GO:0000785
GO:0001934
GO:0002020
GO:0005102
GO:0005109
GO:0005515
GO:0005694
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0007010
GO:0008013
GO:0009410
GO:0016055
GO:0022603
GO:0023052
GO:0030154
GO:0031267
GO:0032880
GO:0032956
GO:0035556
GO:0035567
GO:0036211
GO:0043226
GO:0043547
GO:0045893
GO:0045944
GO:0046330
GO:0048856
GO:0050821
GO:0060070
GO:0060071
GO:0090179
GO:0150012
HMNXSV003024421
ILMN_2137464
PH_hs_0024349
TC03000993.hg
g1277022_3p_s_at
g6806886_3p_at
Participates
as a member of
p-DVL [cytosol] (Homo sapiens)
as a candidate of
p-DVL [cytosol] (Homo sapiens)
Other forms of this molecule
pp-DVL3 [cytosol]
DVL3 [cytosol]
ub-DVL3 [cytosol]
Inferred To
Homologues of p-DVL3 [cytosol]
(Caenorhabditis elegans)
phospho-dsh-1 [cytosol]
(Caenorhabditis elegans)
phospho-dvl3 [cytosol]
(Xenopus tropicalis)
phospho-DVL3 [cytosol]
(Bos taurus)
phospho-DVL3 [cytosol]
(Canis familiaris)
phospho-DVL3 [cytosol]
(Sus scrofa)
phospho-p-DVL3 [cytosol]
(Gallus gallus)
phospho-dsh [cytosol]
(Drosophila melanogaster)
phospho-Dvl3 [cytosol]
(Mus musculus)
phospho-Dvl3 [cytosol]
(Rattus norvegicus)
phospho-mig-5 [cytosol]
(Caenorhabditis elegans)
phospho-dsh-2 [cytosol]
(Caenorhabditis elegans)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
RefSeq
NP_004414.3
OpenTargets
ENSG00000161202
HPA
ENSG00000161202-DVL3
GeneCards
Q92997
ZINC target
Q92997
Ensembl
ENST00000313143
,
ENSG00000161202
,
ENST00000431765
,
ENSP00000405885
,
ENSP00000316054
PRO
Q92997
Pharos - Targets
Q92997
Orphanet
23684
PDB
6V7O
,
6ZC7
,
6ZC4
,
6ZC6
,
6ZC8
,
6ZC3
,
6ZBQ
,
6ZBZ
Interactors (33)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49674 CSNK1E
2
CSNK1E [nucleoplasm]
(R-HSA-421306)
CSNK1E [cytosol]
(R-HSA-205877)
0.805
9
UniProt:P19544 WT1
1
WT1 [nucleoplasm]
(R-HSA-452420)
0.668
3
UniProt:P48730 CSNK1D
3
CSNK1D [nucleoplasm]
(R-HSA-421305)
CSNK1D [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5685717)
CSNK1D [cytosol]
(R-HSA-380315)
0.666
4
UniProt:O14640 DVL1
4
pp-DVL1 [cytosol]
(R-HSA-3772396)
p-S-DVL1 [cytosol]
(R-HSA-201700)
DVL1 [cytosol]
(R-HSA-201687)
ub-DVL1 [cytosol]
(R-HSA-4641157)
0.633
5
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q99633 PRPF18
1
PRPF18 [nucleoplasm]
(R-HSA-5688093)
0.556
3
UniProt:P31273 HOXC8
1
HOXC8 [nucleoplasm]
(R-HSA-3222311)
0.556
3
UniProt:Q9UPV0 CEP164
1
CEP164 [cytosol]
(R-HSA-380305)
0.556
5
UniProt:Q96T60 PNKP
1
PNKP [nucleoplasm]
(R-HSA-5649651)
0.556
3
UniProt:Q8NAV1 PRPF38A
1
PRPF38A [nucleoplasm]
(R-HSA-8867897)
0.556
3
UniProt:O75689 ADAP1
1
ADAP1 [cytosol]
(R-HSA-9612262)
0.556
3
UniProt:O14503 BHLHE40
1
BHLHE40 [nucleoplasm]
(R-HSA-879741)
0.556
3
UniProt:Q9UIH9 KLF15
1
KLF15 [nucleoplasm]
(R-HSA-8878735)
0.556
5
UniProt:Q9UBU9 NXF1
2
NXF1 [cytosol]
(R-HSA-156481)
NXF1 [nucleoplasm]
(R-HSA-111690)
0.556
3
UniProt:O43463 SUV39H1
1
SUV39H1 [nucleoplasm]
(R-HSA-427517)
0.556
3
UniProt:P61289 PSME3
1
PSME3 [cytosol]
(R-HSA-68816)
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.556
3
UniProt:Q15696 ZRSR2
1
ZRSR2 [nucleoplasm]
(R-HSA-8865914)
0.556
3
UniProt:O43474 KLF4
1
KLF4 [nucleoplasm]
(R-HSA-434463)
0.556
3
UniProt:P23025 XPA
1
XPA [nucleoplasm]
(R-HSA-67437)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q14498 RBM39
1
RBM39 [nucleoplasm]
(R-HSA-9770254)
0.556
3
UniProt:Q9UGY1 NOL12
1
NOL12 [nucleoplasm]
(R-HSA-6791195)
0.556
3
UniProt:O95363 FARS2
1
FARS2(1-?) [mitochondrial matrix]
(R-HSA-379565)
0.556
3
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.556
3
UniProt:O43159 RRP8
1
RRP8 [nucleoplasm]
(R-HSA-427524)
0.556
3
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.543
4
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.527
2
UniProt:O95926 SYF2
1
SYF2 [nucleoplasm]
(R-HSA-8867884)
0.527
2
UniProt:O14641 DVL2
5
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
DVL2 [cytosol]
(R-HSA-201694)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.527
3
UniProt:Q9ULK5 VANGL2
2
VANGL2 [plasma membrane]
(R-HSA-3965373)
pS5,S82,S84-VANGL2 [plasma membrane]
(R-HSA-4551547)
0.527
2
UniProt:Q8WUD4 CCDC12
1
CCDC12 [nucleoplasm]
(R-HSA-9769561)
0.527
2
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.524
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
