Reactome | RDX [cytosol]

RDX [cytosol]

Stable Identifier

R-HSA-437348

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Radixin, RADI_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - L1CAM interactions (Homo sapiens)
      - Recycling pathway of L1 (Homo sapiens)
        
        Dephosphorylation of pL1 (Y1176) (Homo sapiens)
        
        ERM:PIP2 [plasma membrane] (Homo sapiens)
        
        ERM [cytosol] (Homo sapiens)
        
        RDX [cytosol] (Homo sapiens)
        
        pL1:ERM:F-actin [plasma membrane] (Homo sapiens)
        
        L1 trans-homodimer [plasma membrane] (Homo sapiens)
        
        pL1:Ezrin [plasma membrane] (Homo sapiens)
        
        ERM:PIP2 [plasma membrane] (Homo sapiens)
        
        ERM [cytosol] (Homo sapiens)
        
        RDX [cytosol] (Homo sapiens)
        
        L1 binds ERM family members (Homo sapiens)
        
        ERM:PIP2 [plasma membrane] (Homo sapiens)
        
        ERM [cytosol] (Homo sapiens)
        
        RDX [cytosol] (Homo sapiens)
        
        pL1:Ezrin [plasma membrane] (Homo sapiens)
        
        ERM:PIP2 [plasma membrane] (Homo sapiens)
        
        ERM [cytosol] (Homo sapiens)
        
        RDX [cytosol] (Homo sapiens)
        
        L1 trans-homophilic interaction (Homo sapiens)
        
        L1 trans-homodimer [plasma membrane] (Homo sapiens)
        
        pL1:Ezrin [plasma membrane] (Homo sapiens)
        
        ERM:PIP2 [plasma membrane] (Homo sapiens)
        
        ERM [cytosol] (Homo sapiens)
        
        RDX [cytosol] (Homo sapiens)
        
        pL1:Ezrin [plasma membrane] (Homo sapiens)
        
        ERM:PIP2 [plasma membrane] (Homo sapiens)
        
        ERM [cytosol] (Homo sapiens)
        
        RDX [cytosol] (Homo sapiens)
        
        Linkage of L1 with treadmilling F-actin (Homo sapiens)
        
        L1 trans-homodimer [plasma membrane] (Homo sapiens)
        
        pL1:Ezrin [plasma membrane] (Homo sapiens)
        
        ERM:PIP2 [plasma membrane] (Homo sapiens)
        
        ERM [cytosol] (Homo sapiens)
        
        RDX [cytosol] (Homo sapiens)
        
        pL1:ERM:F-actin [plasma membrane] (Homo sapiens)
        
        L1 trans-homodimer [plasma membrane] (Homo sapiens)
        
        pL1:Ezrin [plasma membrane] (Homo sapiens)
        
        ERM:PIP2 [plasma membrane] (Homo sapiens)
        
        ERM [cytosol] (Homo sapiens)
        
        RDX [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35241 RDX

Gene Names

RDX

Chain

chain:1-583

Reference Genes

BioGPS Gene:5962 RDX

COSMIC (genes):RDX RDX

CTD Gene:5962 RDX

dbSNP Gene:5962 RDX

ENSEMBL:ENSG00000137710 RDX

ENSEMBL_homo_sapiens_GENE:ENSG00000137710.17 RDX

HGNC:9944 RDX

KEGG Gene (Homo sapiens):5962 RDX

Monarch:5962 RDX

NCBI Gene:5962 RDX

OMIM:179410 RDX

UCSC:P35241 RDX

Reference Transcript

Other Identifiers

11717524_s_at

11717525_s_at

11717526_a_at

11717527_a_at

11748967_a_at

11748968_x_at

11759725_a_at

11761819_a_at

16744174

204969_PM_s_at

204969_s_at

212397_PM_at

212397_at

212398_PM_at

212398_at

244739_PM_at

244739_at

3360106

3390545

3390552

3390557

3390563

3390570

3390571

3390572

3390573

3390574

3390575

3390576

3390577

3390579

3390581

3390584

3390590

3390591

3390594

3390595

3390597

3390598

3390602

3390604

3390605

3390608

3390612

34886_at

34887_at

3972499

4003523

56730_at

5962

7951554

A_19_P00317164

A_19_P00800682

A_23_P203023

A_33_P3423121

GE491397

GE81208

GO:0000278

GO:0003723

GO:0003779

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005856

GO:0005886

GO:0005902

GO:0005912

GO:0005925

GO:0007010

GO:0007155

GO:0008092

GO:0008360

GO:0008361

GO:0010628

GO:0010737

GO:0016020

GO:0016192

GO:0016324

GO:0023052

GO:0030027

GO:0030154

GO:0030163

GO:0030175

GO:0030315

GO:0030335

GO:0030496

GO:0030864

GO:0032154

GO:0032231

GO:0032487

GO:0034111

GO:0034260

GO:0034330

GO:0036120

GO:0042995

GO:0043087

GO:0043226

GO:0045176

GO:0045177

GO:0045296

GO:0045732

GO:0045792

GO:0048856

GO:0048870

GO:0050839

GO:0051016

GO:0051018

GO:0051117

GO:0051286

GO:0051693

GO:0061028

GO:0061951

GO:0065003

GO:0070062

GO:0071944

GO:0072659

GO:0097067

GO:1900027

GO:1900087

GO:1902115

GO:1902966

GO:1903392

GO:2000643

HMNXSV003003266

HMNXSV003047070

Hs.263671.0.A1_3p_at

Hs.263671.0.A2_3p_at

Hs.96297.0.A1_3p_at

ILMN_1708611

L02320_at

PH_hs_0029542

TC11002274.hg

TC11003334.hg

g4506466_3p_s_at

Participates

as a candidate of

ERM [cytosol] (Homo sapiens)

Other forms of this molecule

p-T564-RDX [cytosol]

Inferred To

RDX [cytosol] (Caenorhabditis elegans)

RDX [cytosol] (Mus musculus)

RDX [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001247424.1, NP_001247421.1, NP_002897.1, NP_001247423.1, NP_001247425.1, NP_001247422.1

OpenTargets

ENSG00000137710

HPA

ENSG00000137710-RDX

GeneCards

P35241

Ensembl

ENSP00000436277, ENST00000530301, ENST00000530749, ENSG00000137710, ENSP00000433580, ENSP00000445826, ENST00000645495, ENST00000647231, ENST00000544551, ENST00000528498, ENSP00000432112, ENSP00000496503, ENSP00000437301, ENSP00000496414, ENST00000528900

PRO

P35241

Pharos - Targets

P35241

Orphanet

17298

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.813	10
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	10
UniProt:P52565 ARHGDIA	1	ARHGDIA [cytosol] (R-HSA-194478)	0.544	2
UniProt:P10911 MCF2	1	MCF2 [cytosol] (R-HSA-3006639)	0.544	2
UniProt:P26038 MSN	4	MSN [cytosol] (R-HSA-437350) MSN(2-448)-ALK(1064-1620) fusion [cytosol] (R-HSA-9711966) MSN(2-448)-p-7Y-ALK(1064-1620) fusion [cytosol] (R-HSA-9711971) p-T558-MSN [cytosol] (R-HSA-9663005)	0.527	2