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GIT2 [cytosol]
Stable Identifier
R-HSA-446034
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ARF GTPase-activating protein GIT2, GIT2_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 binds effectors at the plasma membrane (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
GIT2 [cytosol] (Homo sapiens)
CDC42:GTP:CDC42 effectors [plasma membrane] (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
GIT2 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 binds effectors at the plasma membrane (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
GIT2 [cytosol] (Homo sapiens)
RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
GIT2 [cytosol] (Homo sapiens)
RAC2 GTPase cycle (Homo sapiens)
RAC2 binds effectors at the plasma membrane (Homo sapiens)
RAC2 plasma membrane effectors [cytosol] (Homo sapiens)
GIT2 [cytosol] (Homo sapiens)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Homo sapiens)
RAC2 plasma membrane effectors [cytosol] (Homo sapiens)
GIT2 [cytosol] (Homo sapiens)
RAC3 GTPase cycle (Homo sapiens)
RAC3 binds effectors at the plasma membrane (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
GIT2 [cytosol] (Homo sapiens)
RAC3:GTP:RAC3 effectors [plasma membrane] (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
GIT2 [cytosol] (Homo sapiens)
RHOJ GTPase cycle (Homo sapiens)
RHOJ binds effectors at the plasma membrane (Homo sapiens)
RHOJ effectors [cytosol] (Homo sapiens)
GIT2 [cytosol] (Homo sapiens)
RHOJ:GTP:RHOJ effectors [plasma membrane] (Homo sapiens)
RHOJ effectors [cytosol] (Homo sapiens)
GIT2 [cytosol] (Homo sapiens)
RHOQ GTPase cycle (Homo sapiens)
RHOQ binds effectors at the plasma membrane (Homo sapiens)
RHOQ effectors [cytosol] (Homo sapiens)
GIT2 [cytosol] (Homo sapiens)
RHOQ:GTP:RHOQ effectors [plasma membrane] (Homo sapiens)
RHOQ effectors [cytosol] (Homo sapiens)
GIT2 [cytosol] (Homo sapiens)
RHOU GTPase cycle (Homo sapiens)
RHOU binds effectors at the plasma membrane (Homo sapiens)
RHOU effectors [cytosol] (Homo sapiens)
GIT2 [cytosol] (Homo sapiens)
RHOU:GTP:RHOU effectors [plasma membrane] (Homo sapiens)
RHOU effectors [cytosol] (Homo sapiens)
GIT2 [cytosol] (Homo sapiens)
RHOV GTPase cycle (Homo sapiens)
RHOV binds effectors at the plasma membrane (Homo sapiens)
RHOV effectors [cytosol] (Homo sapiens)
GIT2 [cytosol] (Homo sapiens)
RHOV:GTP:RHOV effectors [plasma membrane] (Homo sapiens)
RHOV effectors [cytosol] (Homo sapiens)
GIT2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14161 GIT2
Gene Names
GIT2, KIAA0148
Chain
chain:1-759
Reference Genes
BioGPS Gene:9815 GIT2
COSMIC (genes):GIT2 GIT2
CTD Gene:9815 GIT2
dbSNP Gene:9815 GIT2
ENSEMBL:ENSG00000139436 GIT2
ENSEMBL_homo_sapiens_GENE:ENSG00000139436.22 GIT2
HGNC:4273 GIT2
KEGG Gene (Homo sapiens):9815 GIT2
Monarch:9815 GIT2
NCBI Gene:9815 GIT2
OMIM:608564 GIT2
UCSC:Q14161 GIT2
Reference Transcript
RefSeq:XM_006719709.3 GIT2
RefSeq:NM_014776.4 GIT2
RefSeq:NM_001135214.2 GIT2
RefSeq:XM_006719707.3 GIT2
RefSeq:NM_057169.4 GIT2
RefSeq:NM_001330153.1 GIT2
RefSeq:NM_001135213.2 GIT2
RefSeq:NM_057170.4 GIT2
Other Identifiers
11721292_a_at
11721293_x_at
11721294_a_at
11722765_a_at
11726234_a_at
11746868_a_at
16769983
204982_PM_at
204982_at
209876_PM_at
209876_at
225558_PM_at
225558_at
3471003
3471004
3471006
3471007
3471008
3471009
3471011
3471013
3471015
3471019
3471020
3471021
3471022
3471023
3471027
3471028
3471030
3471033
3471034
3471037
3471039
3471042
3471048
3471051
3471052
3471053
3471054
3471055
3471062
3471063
3471064
3471065
36741_at
48613_at
52136_at
59576_at
7966268
9815
A_23_P204436
A_23_P335848
D63482_at
GE57276
GO:0003824
GO:0005096
GO:0005515
GO:0005634
GO:0005654
GO:0005925
GO:0007420
GO:0008277
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0031267
GO:0032012
GO:0036465
GO:0043226
GO:0045202
GO:0046872
GO:0048856
GO:0098772
GO:0098793
HMNXSV003002126
HMNXSV003014175
HMNXSV003049461
Hs.314029.0.A1_3p_at
ILMN_1760922
ILMN_2355776
PH_hs_0025084
TC12001959.hg
g4691727_3p_at
g4691727_3p_x_at
g7661943_3p_at
Participates
as a candidate of
RHOV effectors [cytosol] (Homo sapiens)
RHOQ effectors [cytosol] (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
RAC2 plasma membrane effectors [cytosol] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
RHOJ effectors [cytosol] (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
RHOU effectors [cytosol] (Homo sapiens)
Inferred To
git-1 [cytosol]
(Caenorhabditis elegans)
GIT2 [cytosol]
(Bos taurus)
GIT2 [cytosol]
(Canis familiaris)
GIT2 [cytosol]
(Gallus gallus)
GIT2 [cytosol]
(Sus scrofa)
Git [cytosol]
(Drosophila melanogaster)
Git2 [cytosol]
(Mus musculus)
Git2 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_476510.1
,
NP_001128686.1
,
NP_476511.1
,
XP_006719772.1
,
NP_001128685.1
,
NP_001317082.1
,
XP_006719770.1
,
NP_055591.2
OpenTargets
ENSG00000139436
GeneCards
Q14161
HPA
ENSG00000139436-GIT2
Ensembl
ENST00000553118
,
ENSP00000447465
,
ENSP00000391813
,
ENST00000547815
,
ENSG00000139436
,
ENST00000361006
,
ENST00000457474
,
ENSP00000450348
,
ENST00000355312
,
ENSP00000354282
,
ENSP00000347464
PRO
Q14161
Pharos - Targets
Q14161
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49023 PXN
4
p-Y-PXN [plasma membrane]
(R-HSA-9031680)
PXN [plasma membrane]
(R-HSA-180493)
PXN [cytosol]
(R-HSA-210014)
p-Y31,Y118-PXN [cytosol]
(R-HSA-5218693)
0.688
4
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
0.669
3
UniProt:Q13153 PAK1
5
PAK1 [plasma membrane]
(R-HSA-3928409)
p-S144,T423-PAK1 [plasma membrane]
(R-HSA-3928472)
Active PAK1 [cytosol]
(R-HSA-8964622)
PAK1 [cytosol]
(R-HSA-162629)
p-S144,T423-PAK1 [cytosol]
(R-HSA-399819)
0.669
4
UniProt:Q14155 ARHGEF7
1
ARHGEF7 [cytosol]
(R-HSA-430346)
0.669
5
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.618
6
UniProt:Q9Y2X7 GIT1
2
GIT1 [cytosol]
(R-HSA-430326)
p-Y383-GIT1 [cytosol]
(R-HSA-3928463)
0.564
2
UniProt:Q16566 CAMK4
4
CAMK4 [cytosol]
(R-HSA-57900)
CAMK4 [nucleoplasm]
(R-HSA-112280)
p-T200-CAMK4 [nucleoplasm]
(R-HSA-9619155)
p-S12,S13,T200-CAMK4 [nucleoplasm]
(R-HSA-111902)
0.527
2
UniProt:P53611 RABGGTB
2
RABGGTB [plasma membrane]
(R-HSA-6801098)
RABGGTB [cytosol]
(R-HSA-8870419)
0.527
2
UniProt:P16333 NCK1
2
NCK1 [cytosol]
(R-HSA-197954)
NCK1 [plasma membrane]
(R-HSA-202992)
0.527
3
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.527
3
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.508
2
UniProt:Q9ES28
1
Arhgef7 [cytosol]
(R-MMU-430346)
0.499
2
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