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Me2K28-HIST2H3A [nucleoplasm]
Stable Identifier
R-HSA-4754197
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone H3.2, HIST2H3C, HIST2H3D
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HDMs demethylate histones (Homo sapiens)
KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Homo sapiens)
Me2K28-histone H3 [nucleoplasm] (Homo sapiens)
Me2K28-HIST2H3A [nucleoplasm] (Homo sapiens)
KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Homo sapiens)
Me2K28-histone H3 [nucleoplasm] (Homo sapiens)
Me2K28-HIST2H3A [nucleoplasm] (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Homo sapiens)
Me2K28-histone H3 [nucleoplasm] (Homo sapiens)
Me2K28-HIST2H3A [nucleoplasm] (Homo sapiens)
WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Homo sapiens)
Me2K28-histone H3 [nucleoplasm] (Homo sapiens)
Me2K28-HIST2H3A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q71DI3 H3C15
Gene Names
H3C15, HIST2H3A, H3C14, H3F2, H3FM, HIST2H3C, H3C13, HIST2H3D
Chain
chain:1-136
Reference Genes
BioGPS Gene:126961 H3C15
BioGPS Gene:333932 H3C15
BioGPS Gene:653604 H3C15
CTD Gene:126961 H3C15
CTD Gene:333932 H3C15
CTD Gene:653604 H3C15
dbSNP Gene:126961 H3C15
dbSNP Gene:333932 H3C15
dbSNP Gene:653604 H3C15
ENSEMBL:ENSG00000183598 HIST2H3D
ENSEMBL:ENSG00000203811 HIST2H3C
ENSEMBL:ENSG00000203852 HIST2H3A
ENSEMBL_homo_sapiens_GENE:ENSG00000183598.4 H3C15
ENSEMBL_homo_sapiens_GENE:ENSG00000203811.2 H3C15
ENSEMBL_homo_sapiens_GENE:ENSG00000203852.4 H3C15
HGNC:20503 H3C15
HGNC:20505 H3C15
HGNC:25311 H3C15
KEGG Gene (Homo sapiens):126961 H3C15
KEGG Gene (Homo sapiens):333932 H3C15
KEGG Gene (Homo sapiens):653604 H3C15
Monarch:126961 H3C15
Monarch:333932 H3C15
Monarch:653604 H3C15
NCBI Gene:126961 H3C15
NCBI Gene:333932 H3C15
NCBI Gene:653604 H3C15
OMIM:142780 H3C15
UCSC:Q71DI3 H3C15
Reference Transcript
RefSeq:NM_001123375.2 H3C15
RefSeq:NM_001005464.2 H3C15
RefSeq:NM_021059.2 H3C15
Other Identifiers
11742410_s_at
126961
16670387
16692614
16692616
2357939
2357940
2434047
2434082
2434083
333932
653604
7905085
7919589
7919612
7919614
ADDON002755.hg
ADDON002789.hg
A_23_P115375
A_24_P324465
A_24_P45651
A_33_P3257678
GE79559
GO:0000786
GO:0003677
GO:0005198
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005694
GO:0006325
GO:0006334
GO:0030527
GO:0043226
GO:0043229
GO:0046982
GO:0065003
GO:0070062
HMNXSV003021896
HMNXSV003029395
ILMN_1664706
ILMN_1666179
PH_hs_0030802
PH_hs_0034534
TC01001175.hg
TC01003173.hg
TC01003188.hg
TC01003189.hg
Participates
as a candidate of
Me2K28-histone H3 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
2xAcK-HIST2H3A [nucleoplasm]
Me1K5-HIST2H3A [nucleoplasm]
Me2aR27-HIST2H3A [nucleoplasm]
Me2aR18-HIST2H3A [nucleoplasm]
Me2sR9-HIST2H3A [nucleoplasm]
Me2sR3-HIST2H3A [nucleoplasm]
AcK9,14-p-S10-HIST2H3A [nucleoplasm]
AcK14,18,79-p-S10-HIST2H3A [nucleoplasm]
AcK9,14,18-p-S10,T11-HIST2H3A [nucleoplasm]
AcK14,18-p-S10,T11-HIST2H3A [nucleoplasm]
AcK9,14,18,79-p-S10,T11-HIST2H3A [nucleoplasm]
AcK14,18-p-S10-HIST2H3A [nucleoplasm]
AcK14,18,79-p-T11-HIST2H3A [nucleoplasm]
AcK14,18-p-T11-HIST2H3A [nucleoplasm]
AcK14,18,79-p-S10,T11-HIST2H3A [nucleoplasm]
MeK37-HIST2H3A [nucleoplasm]
MeK80-HIST2H3A [nucleoplasm]
Me3K80-HIST2H3A [nucleoplasm]
Me2K80-HIST2H3A [nucleoplasm]
Me3K37-HIST2H3A [nucleoplasm]
Me2K37-HIST2H3A [nucleoplasm]
MeK-HIST2H3A [nucleoplasm]
MeK28-HIST2H3A [nucleoplasm]
MeK10-HIST2H3A [cytosol]
HIST2H3A [cytosol]
Me2aR3-HIST2H3A [nucleoplasm]
MeK5-HIST2H3A [nucleoplasm]
Cit27-HIST2H3A [nucleoplasm]
Cit3-HIST2H3A [nucleoplasm]
Cit9-HIST2H3A [nucleoplasm]
Cit18-HIST2H3A [nucleoplasm]
MeR18-HIST2H3A [nucleoplasm]
MeR3-HIST2H3A [nucleoplasm]
MeR27-HIST2H3A [nucleoplasm]
MeR9-HIST2H3A [nucleoplasm]
Me2K5,Me2aR3-HIST2H3A [nucleoplasm]
Ack10-HIST2H3A [nucleoplasm]
HIST2H3A [extracellular region]
AcK24-HIST2H3A [nucleoplasm]
Ack15-HIST2H3A [nucleoplasm]
AcK19-HIST2H3A [nucleoplasm]
AcK5-HIST2H3A [nucleoplasm]
Me2K10-HIST2H3A [nucleoplasm]
p-T12-HIST2H3A [nucleoplasm]
p-T12,MeK-HIST2H3A [nucleoplasm]
p-T12, Me2K-10-HIST2H3A [nucleoplasm]
p-T12, Me3K-10-HIST2H3A [nucleoplasm]
Me3K10-HIST2H3A [nucleoplasm]
Me3K5-HIST2H3A [nucleoplasm]
Me3K28-HIST2H3A [nucleoplasm]
HIST2H3A [nucleoplasm]
Me2K5-HIST2H3A [nucleoplasm]
Inferred To
H3C15 [nucleoplasm]
(Sus scrofa)
H3c4 [nucleoplasm]
(Mus musculus)
cnp1 [nucleoplasm]
(Schizosaccharomyces pombe)
Me2K28-HIST2H3A [nucleoplasm]
(Bos taurus)
H3a [nucleoplasm]
(Dictyostelium discoideum)
Me2K28-HIST1H3A [nucleoplasm]
(Plasmodium falciparum)
CSE4 [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of Me2K28-HIST1H3A [nucleoplasm]
(Plasmodium falciparum)
hcp-3 [nucleoplasm]
(Caenorhabditis elegans)
Hist2h3c2 [nucleoplasm]
(Rattus norvegicus)
Modified Residues
Name
N6,N6-dimethyl-L-lysine at 28
Coordinate
28
PsiMod Name
N6,N6-dimethyl-L-lysine [MOD:00084]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6,N6-dimethyl-L-lysine.
Cross References
RefSeq
NP_001116847.1
,
NP_066403.2
,
NP_001005464.1
OpenTargets
ENSG00000203852
HPA
ENSG00000183598-H3C13
,
ENSG00000203852-H3C15
,
ENSG00000203811-H3C14
GeneCards
Q71DI3
Ensembl
ENST00000331491
,
ENST00000403683
,
ENST00000369158
,
ENSP00000333277
,
ENSG00000183598
,
ENSP00000385479
,
ENSP00000358154
,
ENSG00000203852
,
ENSG00000203811
PRO
Q71DI3
Pharos - Targets
Q71DI3
PDB
7TAN
,
7U51
,
7PEX
,
7U50
,
5CIU
,
2IIJ
,
7PF0
,
3QO2
,
7PEY
,
3R93
,
7PEV
,
7UVA
,
7JOA
,
3DB3
,
6FML
,
7PEW
,
7PFX
,
7PET
,
7PF4
,
7PFF
,
2X4X
,
7PEU
,
7PF5
,
8AV6
,
7PFE
,
2X4W
,
7PEZ
,
7BU9
,
6Y5D
,
7PF2
,
7PF3
,
5BO0
,
3AV1
,
2X4Y
,
5VAC
,
7XCR
,
7PFT
,
4OUC
,
6X5A
,
6T79
,
7XCT
,
7PFA
,
7PFU
,
6T7C
,
6T7D
,
5B0Y
,
4MZG
,
5B0Z
,
8ATF
,
6X59
,
4MZF
,
7PF6
,
7UV9
,
7JO9
,
7JZV
,
6T7B
,
8AAG
,
6Y5E
,
4MZH
,
7BQZ
,
6ACE
,
8JLB
,
7PFV
,
8OL1
,
7U53
,
3MO8
,
7U52
,
5B40
,
8JLD
,
8GRQ
,
7XD0
,
7PFD
,
7PFC
,
6XJD
,
7YRD
,
6T7A
,
7PFW
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62805 H4C1
17
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
HIST1H4A [extracellular region]
(R-HSA-977569)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
0.704
4
UniProt:Q9Y294 ASF1A
1
ASF1A [nucleoplasm]
(R-HSA-417169)
0.576
4
UniProt:P49736 MCM2
1
MCM2 [nucleoplasm]
(R-HSA-68557)
0.576
5
UniProt:Q96CV9 OPTN
6
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [cytosol]
(R-HSA-9687907)
p-S177,S473,S513-OPTN [cytosol]
(R-HSA-9687840)
0.556
3
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.556
3
UniProt:P29474 NOS3
9
2xPalmC-MyrG-p-S1177,S1179-NOS3 [plasma membrane]
(R-HSA-9860783)
2xPalmC-MyrG-p-S633-NOS3 [plasma membrane]
(R-HSA-9861341)
2xPalmC-MyrG-NOS3 [endocytic vesicle membrane]
(R-HSA-535007)
2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane]
(R-HSA-202139)
MyrG-NOS3 [Golgi membrane]
(R-HSA-534995)
MyrG-NOS3 [cytosol]
(R-HSA-203687)
2xPalmC-MyrG-NOS3 [plasma membrane]
(R-HSA-534993)
2xPalmC-MyrG-NOS3 [Golgi membrane]
(R-HSA-203769)
NOS3 [cytosol]
(R-HSA-202114)
0.556
3
UniProt:P37840 SNCA
5
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
Ub-SNCA [cytosol]
(R-HSA-5660754)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
SNCA [cytosol]
(R-HSA-5658500)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
18
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
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