Reactome | WNT5A-dependent internalization of FZD4

WNT5A-dependent internalization of FZD4

Stable Identifier

R-HSA-5099900

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region, clathrin-coated endocytic vesicle, clathrin-coated endocytic vesicle membrane

ReviewStatus

5/5

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WNT5A induces internalization of FZD4 in a manner that depends upon PKC-mediated phosphorylation of DVL2. Uptake of FZD4 appears to occur in a clathrin, AP-2 and ARBB2-dependent mannner (Chen et al, 2003; Yu et al, 2007; Yu et al, 2010).

Literature References

PubMed ID	Title	Journal	Year
17199046	Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling Yu, A, Rual, JF, Tamai, K, Harada, Y, Vidal, M, He, X, Kirchhausen, T	Dev. Cell	2007
12958364	Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4 Chen, W, ten Berge, D, Brown, J, Ahn, S, Hu, LA, Miller, WE, Caron, MG, Barak, LS, Nusse, R, Lefkowitz, RJ	Science	2003
20947020	Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling Yu, A, Xing, Y, Harrison, SC, Kirchhausen, T	Structure	2010