WNT5A-dependent internalization of FZD4

Stable Identifier
R-HSA-5099900
Type
Pathway
Species
Homo sapiens
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WNT5A induces internalization of FZD4 in a manner that depends upon PKC-mediated phosphorylation of DVL2. Uptake of FZD4 appears to occur in a clathrin, AP-2 and ARBB2-dependent mannner (Chen et al, 2003; Yu et al, 2007; Yu et al, 2010).

Literature References
PubMed ID Title Journal Year
17199046 Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling

Rual, JF, Yu, A, Vidal, M, Kirchhausen, T, Harada, Y, Tamai, K, He, X

Dev. Cell 2007
12958364 Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4

Chen, W, Ahn, S, Caron, MG, Barak, LS, Brown, J, Hu, LA, Lefkowitz, RJ, Nusse, R, Miller, WE, ten Berge, D

Science 2003
20947020 Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling

Yu, A, Xing, Y, Kirchhausen, T, Harrison, SC

Structure 2010
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