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PINK1 [mitochondrial intermembrane space]
Stable Identifier
R-HSA-5205671
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial intermembrane space
Synonyms
Serine/threonine-protein kinase PINK1, mitochondrial ecNumber2.7.11.1/ecNumber, PINK1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Mitophagy (Homo sapiens)
PINK1-PRKN Mediated Mitophagy (Homo sapiens)
Pink1 is cleaved on healthy mitochondria (Homo sapiens)
PINK1 [mitochondrial intermembrane space] (Homo sapiens)
Pink1 is recruited from the cytoplasm to the mitochondria (Homo sapiens)
PINK1 [mitochondrial intermembrane space] (Homo sapiens)
Uncleaved Pink1 accumulates in damaged mitochondria (Homo sapiens)
PINK1 [mitochondrial intermembrane space] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BXM7 PINK1
Gene Names
PINK1
Chain
transit peptide:1-77, chain:78-581
Reference Genes
COSMIC (genes):PINK1 PINK1
dbSNP Gene:65018 PINK1
ENSEMBL:ENSG00000158828 PINK1
Participates
as an input of
Pink1 is cleaved on healthy mitochondria (Homo sapiens)
Uncleaved Pink1 accumulates in damaged mitochondria (Homo sapiens)
as an output of
Pink1 is recruited from the cytoplasm to the mitochondria (Homo sapiens)
Other forms of this molecule
PINK1(111-581) [mitochondrial intermembrane space]
PINK1 [cytosol]
PINK1 [mitochondrial outer membrane]
p-S228,S402-PINK1 [mitochondrial outer membrane]
Inferred To
PINK1 [mitochondrial intermembrane space]
(Bos taurus)
PINK1 [mitochondrial intermembrane space]
(Caenorhabditis elegans)
PINK1 [mitochondrial intermembrane space]
(Canis familiaris)
PINK1 [mitochondrial intermembrane space]
(Drosophila melanogaster)
PINK1 [mitochondrial intermembrane space]
(Mus musculus)
PINK1 [mitochondrial intermembrane space]
(Rattus norvegicus)
PINK1 [mitochondrial intermembrane space]
(Sus scrofa)
pink1 [mitochondrial intermembrane space]
(Danio rerio)
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60260 PARK2
4
polyUb-PARK2 [cytosol]
(R-HSA-5689094)
p-S9-PRKN [cytosol]
(R-HSA-9793481)
p-S65-PRKN [cytosol]
(R-HSA-9834954)
PRKN [cytosol]
(R-HSA-201579)
0.748
7
UniProt:Q9Y3I1 FBXO7
1
FBXO7 [cytosol]
(R-HSA-8862627)
0.576
8
UniProt:Q8WXH5 SOCS4
1
SOCS4 [cytosol]
(R-HSA-8936109)
0.57
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
0.564
3
UniProt:Q99932-2 SPAG8
0.556
3
UniProt:Q9UHY8 FEZ2
0.556
3
IntAct:EBI-25842456 CCSB
0.556
3
UniProt:P63010-2 AP2B1
0.556
3
UniProt:Q13113 PDZ1I
0.556
3
UniProt:Q8N895 ZN366
0.556
3
UniProt:Q6DN90-2 Q6DN902
0.556
3
UniProt:P00491 PNP
7
PNP [secretory granule lumen]
(R-HSA-6803318)
PNP [extracellular region]
(R-HSA-6806505)
PNP [ficolin-1-rich granule lumen]
(R-HSA-6803278)
PNP [cytosol]
(R-HSA-61933)
PNP D128G [cytosol]
(R-HSA-9735785)
PNP E89K [cytosol]
(R-HSA-9735781)
PNP R234P [cytosol]
(R-HSA-9735772)
0.556
3
UniProt:P28347-2 TEAD1
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:Q9UBQ0-2 VPS29
0.556
3
UniProt:O15392 BIRC5
3
BIRC5 [cytosol]
(R-HSA-50851)
BIRC5 [nucleoplasm]
(R-HSA-4655344)
ub-BIRC5 [cytosol]
(R-HSA-8955933)
0.556
3
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [cytosol]
(R-HSA-5205651)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
0.556
3
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
9
UniProt:Q9BYZ2 LDHAL6B
1
LDHAL6B [mitochondrial matrix]
(R-HSA-6807613)
0.556
3
UniProt:P40763 STAT3
12
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
0.547
2
UniProt:O75153 CLU
0.527
3
UniProt:P48594 SPB4
0.527
2
UniProt:Q8IXI2 RHOT1
2
PolyUb-RHOT1 [mitochondrial outer membrane]
(R-HSA-6783139)
RHOT1 [mitochondrial outer membrane]
(R-HSA-3006728)
0.524
3
UniProt:Q96JZ2 HSH2D
0.488
2
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