Reactome | GPR37L1 [plasma membrane]

GPR37L1 [plasma membrane]

Stable Identifier

R-HSA-5336178

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Prosaposin receptor GPR37L1, ETBR2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O60883 GPR37L1

Gene Names

GPR37L1, ETBRLP2

Chain

signal peptide:1-25, chain:26-481

Reference Genes

BioGPS Gene:9283 GPR37L1

COSMIC (genes):GPR37L1 GPR37L1

CTD Gene:9283 GPR37L1

dbSNP Gene:9283 GPR37L1

ENSEMBL:ENSG00000170075 GPR37L1

HGNC:14923 GPR37L1

KEGG:hsa:9283 GPR37L1

Monarch:9283 GPR37L1

NCBI Gene:9283 GPR37L1

OMIM:617630 GPR37L1

UCSC:O60883 GPR37L1

Reference Transcript

RefSeq:NM_004767.3 GPR37L1

Other Identifiers

11734711_at

11749533_a_at

1556155_PM_at

1556155_at

1558189_PM_a_at

1558189_a_at

16675944

207055_PM_at

207055_at

2375051

2375052

2375053

2375055

2375056

2375057

2375058

2375059

2375060

2375061

2375066

2375067

2375069

2375071

35544_at

42851_g_at

7908812

88190_at

9283

A_14_P127784

A_24_P145633

A_32_P114866

A_32_P212446

A_33_P3351279

GE527263

GE81438

GE897006

GO:0003085

GO:0004930

GO:0005515

GO:0005886

GO:0007186

GO:0007193

GO:0007224

GO:0008528

GO:0016020

GO:0021940

GO:0030154

GO:0034614

GO:0036505

GO:0042277

GO:0042995

GO:0043235

GO:0043410

GO:0045665

GO:0045879

GO:0048712

GO:0060020

GO:0060089

GO:0060170

HMNXSV003000572

HMNXSV003001100

HMNXSV003010385

Hs2.192654.1.S1_3p_s_at

Hs2.348709.1.A1_3p_at

ILMN_1782944

PH_hs_0007873

PH_hs_0011348

TC01001671.hg

TC01004950.hg

TC01004951.hg

TC01004952.hg

g4758309_3p_at

p1334

p28375

Participates

as an input of

GPR37L binds prosaposin (Homo sapiens)

as a component of

GPR37L1:Prosaposin fragments [plasma membrane] (Homo sapiens)

Inferred To

GPR37L1 [plasma membrane] (Bos taurus)

GPR37L1 [plasma membrane] (Canis familiaris)

GPR37L1 [plasma membrane] (Gallus gallus)

GPR37L1 [plasma membrane] (Sus scrofa)

Gpr37l1 [plasma membrane] (Mus musculus)

Gpr37l1 [plasma membrane] (Rattus norvegicus)

gpr37l1b [plasma membrane] (Danio rerio)

gpr37l1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_004758.3

Guide to Pharmacology - Targets

104

OpenTargets

ENSG00000170075

ENSEMBL

ENST00000367282, ENSP00000356251, ENSG00000170075

GeneCards

GPR37L1

HPA

ENSG00000170075-GPR37L1

PRO

O60883

Pharos - Targets

O60883

Interactors (53)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42785 PRCP	3	PRCP [ficolin-1-rich granule membrane] (R-HSA-6800988) PRCP [azurophil granule membrane] (R-HSA-6799240) PRCP [plasma membrane] (R-HSA-158380)	0.558	2
UniProt:Q8TBG9 SYNPR			0.556	3
UniProt:Q14802-3 FXYD3			0.556	3
UniProt:Q8NBI2 CYAC3			0.556	3
UniProt:Q9H9V4 RN122			0.556	3
UniProt:Q96IW7 SEC22A	3	SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111) SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562)	0.556	3
UniProt:Q14108 SCARB2	2	SCARB2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869106) SCARB2 [plasma membrane] (R-HSA-8864566)	0.556	3
UniProt:Q8TDT2 GP152			0.556	3
UniProt:Q9NS64 RPRM			0.556	3
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3
UniProt:P24593 IGFBP5	5	IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956738) p-IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956988) IGFBP5 [extracellular region] (R-HSA-381414) IGFBP5(21-163) [extracellular region] (R-HSA-381415) IGFBP5(164-272) [extracellular region] (R-HSA-381478)	0.556	3
UniProt:Q14162 SCARF1	2	SCARF1 [plasma membrane] (R-HSA-2197636) SCARF1 [endocytic vesicle membrane] (R-HSA-2239453)	0.556	3
UniProt:Q9Y6X1 SERP1	2	SERP1 [endoplasmic reticulum membrane] (R-HSA-381045) SERP1 [cytosol] (R-HSA-5250574)	0.556	3
UniProt:Q8IWU4 SLC30A8	2	SLC30A8 [Golgi membrane] (R-HSA-9817561) SLC30A8 [secretory granule membrane] (R-HSA-437106)	0.556	3
UniProt:Q9BVK8 TM147			0.556	3
UniProt:Q8N5K1 CISD2			0.556	3
UniProt:O60242 AGRB3			0.556	3
UniProt:Q8N2M4 TM86A			0.556	3
UniProt:O15552 FFAR2	1	FFAR2 [plasma membrane] (R-HSA-443944)	0.556	3
UniProt:Q9C0I4 THSD7B	3	THSD7B [endoplasmic reticulum lumen] (R-HSA-5173101) glc-fuc-THSD7B [endoplasmic reticulum lumen] (R-HSA-5172957) O-fuc-THSD7B [endoplasmic reticulum lumen] (R-HSA-5173124)	0.556	3
UniProt:P27105 STOM	4	STOM [tertiary granule membrane] (R-HSA-6800960) STOM [plasma membrane] (R-HSA-6806258) STOM [specific granule membrane] (R-HSA-6799569) STOM [azurophil granule membrane] (R-HSA-6800997)	0.556	3
IntAct:EBI-23343277 CCSB ORF ID			0.556	3
UniProt:O75841 UPK1B			0.556	3
UniProt:P48230 T4S4			0.556	3
UniProt:Q96PS8 AQP10	1	AQP10 [plasma membrane] (R-HSA-431709)	0.556	3
UniProt:Q9BQ51 PDCD1LG2	1	PDCD1LG2 [plasma membrane] (R-HSA-3211774)	0.556	3
UniProt:Q8TED1 GPX8	1	GPX8 [endoplasmic reticulum lumen] (R-HSA-3341303)	0.556	3
UniProt:O95471 CLDN7	2	CLDN7 [plasma membrane] (R-HSA-420004) CLDN7 [cell junction] (R-HSA-421241)	0.556	3
UniProt:Q5BJF2 SGMR2			0.556	3
UniProt:O15529 GPR42			0.556	3
UniProt:Q9Y5U4 INSIG2	1	INSIG2 [endoplasmic reticulum membrane] (R-HSA-1655736)	0.556	3
UniProt:P29972 AQP1	1	AQP1 [plasma membrane] (R-HSA-431700)	0.556	3
UniProt:O14798 TNFRSF10C	1	TNFRSF10C [plasma membrane] (R-HSA-5628831)	0.556	3
UniProt:Q9BU79 TM243			0.556	3
UniProt:Q9H1C4 UNC93B1	4	UNC93B1 [Golgi membrane] (R-HSA-1679064) UNC93B1 [endoplasmic reticulum membrane] (R-HSA-1678930) UNC93B1 P345Pfs103 [endoplasmic reticulum membrane] (R-HSA-9628866) UNC93B1 L230Afs188 [endoplasmic reticulum membrane] (R-HSA-9628869)	0.556	3
UniProt:Q9NWD8 TM248			0.556	3
UniProt:Q8NHS1 CLDN2			0.556	3
UniProt:Q8WY91 THAP4			0.556	3
UniProt:Q96HE8 TMM80			0.556	3
UniProt:A0A087WZY1 A0A087WZY1			0.556	3
UniProt:O95859 TSN12			0.556	3
UniProt:Q8N5M9 JAGN1			0.556	3
UniProt:Q9GZR5 ELOVL4	1	ELOVL4 [endoplasmic reticulum membrane] (R-HSA-548705)	0.556	3
UniProt:P26678 PLN	2	p-S16-PLN [sarcoplasmic reticulum membrane] (R-HSA-5578813) PLN [sarcoplasmic reticulum membrane] (R-HSA-5490319)	0.556	3
UniProt:Q5JX71 F209A			0.556	3
UniProt:Q3SXY8 ARL13B	8	PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986) ARL13B [plasma membrane] (R-HSA-9716787)	0.556	3
UniProt:Q4KMG9 TM52B			0.556	3
UniProt:Q8TAF8 LHFPL5	1	LHFPL5 [plasma membrane] (R-HSA-9658860)	0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:P15529-3 CD46			0.556	3
UniProt:Q9UKR5 ERG28			0.556	3
UniProt:Q6UVW9 CLC2A			0.556	3
UniProt:Q969K7 TMM54			0.556	3

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