Reactome | AQP1 [plasma membrane]

AQP1 [plasma membrane]

Stable Identifier

R-HSA-431700

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Aquaporin-1, AQP1_HUMAN

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External Reference Information

External Reference

UniProt:P29972 AQP1

Gene Names

AQP1, CHIP28

Chain

initiator methionine:, chain:2-269

Reference Genes

BioGPS Gene:358 AQP1

COSMIC (genes):AQP1 AQP1

CTD Gene:358 AQP1

dbSNP Gene:358 AQP1

ENSEMBL:ENSG00000240583 AQP1

HGNC:633 AQP1

KEGG:hsa:358 AQP1

Monarch:358 AQP1

NCBI Gene:358 AQP1

OMIM:107776 AQP1

UCSC:P29972 AQP1

Reference Transcript

RefSeq:NM_198098.3 AQP1

Other Identifiers

11715941_s_at

11715942_a_at

11747177_x_at

11756045_s_at

17044862

207542_PM_s_at

207542_s_at

209047_PM_at

209047_at

2995590

2995591

2995593

2995594

2995595

2995596

2995597

2995598

358

36156_at

8132118

A_14_P131012

A_23_P19894

A_33_P3253723

GE59145

GO:0003014

GO:0003091

GO:0003094

GO:0003097

GO:0005215

GO:0005223

GO:0005267

GO:0005372

GO:0005515

GO:0005634

GO:0005737

GO:0005886

GO:0005901

GO:0005903

GO:0006813

GO:0006833

GO:0006884

GO:0006972

GO:0007010

GO:0007163

GO:0008519

GO:0009925

GO:0009992

GO:0010761

GO:0010763

GO:0015079

GO:0015168

GO:0015250

GO:0015267

GO:0015670

GO:0015793

GO:0016020

GO:0016323

GO:0016324

GO:0016477

GO:0019233

GO:0019725

GO:0019934

GO:0021670

GO:0022600

GO:0022857

GO:0030157

GO:0030184

GO:0030185

GO:0030424

GO:0030950

GO:0031526

GO:0031965

GO:0032940

GO:0033326

GO:0033363

GO:0034644

GO:0035377

GO:0035378

GO:0035379

GO:0042060

GO:0042383

GO:0042476

GO:0042802

GO:0043066

GO:0043154

GO:0043226

GO:0044241

GO:0045177

GO:0045766

GO:0046875

GO:0046878

GO:0048146

GO:0048593

GO:0048856

GO:0048870

GO:0050829

GO:0050877

GO:0050891

GO:0051458

GO:0051649

GO:0055085

GO:0070062

GO:0070295

GO:0070301

GO:0071260

GO:0071280

GO:0071288

GO:0071300

GO:0071320

GO:0071456

GO:0071472

GO:0071474

GO:0071549

GO:0071732

GO:0071805

GO:0072220

GO:0072230

GO:0072232

GO:0072239

GO:0072488

GO:0098542

GO:0098655

GO:0140070

GO:0170014

HMNXSV003011575

Hs.74602.1.S2_3p_at

ILMN_1681103

ILMN_1776857

M77829_s_at

PH_hs_0028973

TC07002236.hg

U41518_at

g4755121_3p_a_at

Participates

as a component of

AQP1 tetramer [plasma membrane] (Homo sapiens)

Inferred To

AQP1 [plasma membrane] (Bos taurus)

AQP1 [plasma membrane] (Canis familiaris)

AQP1 [plasma membrane] (Dictyostelium discoideum)

AQP1 [plasma membrane] (Gallus gallus)

AQP1 [plasma membrane] (Plasmodium falciparum)

AQP1 [plasma membrane] (Sus scrofa)

Drip [plasma membrane] (Drosophila melanogaster)

Eglp2 [plasma membrane] (Drosophila melanogaster)

aqp1a.1 [plasma membrane] (Danio rerio)

aqpA [plasma membrane] (Dictyostelium discoideum)

wacA [plasma membrane] (Dictyostelium discoideum)

Aqp1 [plasma membrane] (Mus musculus)

Aqp1 [plasma membrane] (Rattus norvegicus)

Homologues of AQP1 [plasma membrane] (Dictyostelium discoideum)

Homologues of AQP1 [plasma membrane] (Drosophila melanogaster)

aqp1 [plasma membrane] (Xenopus tropicalis)

Prip [plasma membrane] (Drosophila melanogaster)

bib [plasma membrane] (Drosophila melanogaster)

Eglp3 [plasma membrane] (Drosophila melanogaster)

Eglp4 [plasma membrane] (Drosophila melanogaster)

Eglp1 [plasma membrane] (Drosophila melanogaster)

Cross References

Guide to Pharmacology - Targets

688

OpenTargets

ENSG00000240583

ENSEMBL

ENST00000652696, ENSP00000498672, ENST00000409611, ENSP00000387178, ENST00000409899, ENSP00000311165, ENST00000311813, ENSP00000386712

HPA

ENSG00000240583-AQP1

PRO

P29972

Pharos - Targets

P29972

GlyGen

P29972

HMDB Protein

HMDBP10782

PDB

7UZE, 1IH5, 8CT2, 1FQY, 8CTE, 1H6I, 4CSK, 6POJ

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.556	3
UniProt:Q96LC9 BMF	3	BMF [plasma membrane] (R-HSA-140209) p-BMF(1-89) [cytosol] (R-HSA-140529) p-BMF [mitochondrial outer membrane] (R-HSA-3145026)	0.556	3
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.556	3
UniProt:Q6IN84 MRM1	1	MRM1 [mitochondrial matrix] (R-HSA-6793088)	0.556	3
UniProt:Q9GZV8 PRDM14	1	PRDM14 [nucleoplasm] (R-HSA-1112608)	0.556	3
UniProt:P24592 IGFBP6	1	IGFBP6 [extracellular region] (R-HSA-381475)	0.556	3
UniProt:O60883 GPR37L1	1	GPR37L1 [plasma membrane] (R-HSA-5336178)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:P08151 GLI1	9	ub-GLI1 [cytosol] (R-HSA-5635833) ub-pS-GLI1 [ciliary base] (R-HSA-5610514) pS-GLI1 [ciliary base] (R-HSA-5610497) GLI1 [cytosol] (R-HSA-445457) p-GLI1 [ciliary tip] (R-HSA-5635040) 2p-GLI1 [nucleoplasm] (R-HSA-5635057) p-GLI1 [nucleoplasm] (R-HSA-5635042) GLI1 [ciliary base] (R-HSA-5610357) GLI1 [ciliary tip] (R-HSA-5610360)	0.556	3
UniProt:Q9BUH8 BEGAIN	1	BEGAIN [cytosol] (R-HSA-6794250)	0.556	3
UniProt:O00501 CLDN5	2	CLDN5 [cell junction] (R-HSA-421264) CLDN5 [plasma membrane] (R-HSA-419991)	0.556	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:O43597 SPRY2	8	p-S112,S115-SPRY2 [cytosol] (R-HSA-1295619) SPRY2 [cytosol] (R-HSA-182949) SPRY2 [plasma membrane] (R-HSA-182924) p-S112,S121-SPRY2 [plasma membrane] (R-HSA-934595) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-934555) p-S111,S120-SPRY2 [cytosol] (R-HSA-1295590) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-1295629) p-Y55-SPRY2 [cytosol] (R-HSA-182950)	0.556	3
UniProt:O75525 KHDRBS3	2	KHDRSB3 [nucleoplasm] (R-HSA-8849040) p-Y-KHDRSB3 [nucleoplasm] (R-HSA-8849035)	0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3

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