Reactome | ADAR [nucleoplasm]

ADAR [nucleoplasm]

Stable Identifier

R-HSA-53939

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

ADAR1 protein, P136, 136 kDa double-stranded RNA binding protein, Double-stranded RNA-specific adenosine deaminase , DRADA, Double-stranded RNA-specific adenosine deaminase , K88DSRBP, Interferon-inducible protein 4, IFI-4 protein

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External Reference Information

External Reference

UniProt:P55265 ADAR

Gene Names

ADAR, ADAR1, DSRAD, G1P1, IFI4

Chain

chain:1-1226

Reference Genes

BioGPS Gene:103 ADAR

COSMIC (genes):ADAR ADAR

CTD Gene:103 ADAR

dbSNP Gene:103 ADAR

ENSEMBL:ENSG00000160710 ADAR

ENSEMBL:ENSG00000160710.18 ADAR

HGNC:225 ADAR

KEGG Gene (Homo sapiens):103 ADAR

Monarch:103 ADAR

NCBI Gene:103 ADAR

OMIM:146920 ADAR

UCSC:P55265 ADAR

Reference Transcript

Other Identifiers

103

11739021_a_at

11739022_a_at

11739023_a_at

11739024_s_at

11741719_a_at

11741720_s_at

16693810

16693813

201786_PM_s_at

201786_s_at

2436752

2436753

2436755

2436756

2436757

2436758

2436760

2436762

2436763

2436764

2436766

2436767

2436768

2436770

2436772

2436773

2436774

2436775

2436776

2436777

2436778

2436781

2436782

2436783

2436784

2436785

2436786

2436787

2436789

2436791

2436792

2436793

2436796

2436797

2436799

2436809

2436811

2436813

38014_at

75024_at

7920531

A_23_P200439

A_24_P362317

A_24_P915522

GE60051

GO:0001649

GO:0002244

GO:0002376

GO:0002566

GO:0003677

GO:0003723

GO:0003725

GO:0003726

GO:0003824

GO:0004000

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0006382

GO:0006396

GO:0006397

GO:0006606

GO:0006611

GO:0006886

GO:0006913

GO:0006915

GO:0008251

GO:0009615

GO:0012501

GO:0016020

GO:0016071

GO:0016553

GO:0016787

GO:0023052

GO:0030154

GO:0030218

GO:0031047

GO:0031054

GO:0035196

GO:0035455

GO:0036211

GO:0043226

GO:0044387

GO:0044530

GO:0045070

GO:0045087

GO:0046872

GO:0048856

GO:0051607

GO:0060216

GO:0060339

GO:0061484

GO:0065003

GO:0070922

GO:0097284

GO:0098542

GO:0098586

GO:1900369

GO:1903944

HMNXSV003016025

HMNXSV003051825

ILMN_1776777

ILMN_2320964

PH_hs_0000829

TC01003294.hg

TC01003295.hg

U10439_at

g7669471_3p_a_at

p462

Participates

as an input of

Formation of ADAR1 homodimer (Homo sapiens)

as a component of

ADAR1 homodimer [nucleoplasm] (Homo sapiens)

as an output of

Expression of IFN-induced genes (Homo sapiens)

Other forms of this molecule

ADAR1 [cytosol]

Inferred To

ADAR1 [nucleoplasm] (Gallus gallus)

adar [nucleoplasm] (Xenopus tropicalis)

ADAR [nucleoplasm] (Bos taurus)

ADAR [nucleoplasm] (Canis familiaris)

ADAR [nucleoplasm] (Danio rerio)

ADAR [nucleoplasm] (Mus musculus)

ADAR [nucleoplasm] (Rattus norvegicus)

ADAR [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

XP_006711176.1, NP_056656.2, XP_006711175.1, NP_001020278.1, NP_001180424.1, NP_001102.2, XP_006711174.1, NP_056655.2

OpenTargets

ENSG00000160710

GeneCards

P55265

HPA

ENSG00000160710-ADAR

Ensembl

ENST00000649022, ENSP00000506666, ENSP00000496896, ENSP00000505532, ENST00000649042, ENSP00000357459, ENST00000648311, ENSP00000498137, ENST00000529168, ENSP00000357456, ENST00000648231, ENST00000681056, ENST00000368474, ENSP00000431794, ENST00000368471, ENST00000649749, ENSG00000160710, ENSP00000497210, ENST00000680270, ENST00000681683, ENST00000649724, ENSP00000506234, ENSP00000497932, ENSP00000497790, ENSP00000497555

PRO

P55265

Pharos - Targets

P55265

Orphanet

15467

PDB

2GXB, 3IRQ, 5ZUO, 2MDR, 1XMK, 5ZUP, 8GBC, 1QGP, 3F21, 2ACJ, 3IRR, 3F22, 1QBJ, 8GBD, 7C0I, 2L54, 3F23, 5ZU1

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P03496 NS	2	NS1 [nucleoplasm] (R-FLU-169113) NS1 [cytosol] (R-FLU-169118)	0.655	8
UniProt:Q13148 TADBP			0.556	3
UniProt:Q13618 CUL3	3	CUL3 [cytosol] (R-HSA-975979) CUL3 [nucleoplasm] (R-HSA-5635033) G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516)	0.527	2
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.524	3
UniProt:P14340-PRO_0000037965			0.508	2
UniProt:Q99IB8-PRO_0000045599			0.488	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	14