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PRKCD(330-676) [azurophil granule lumen]
Stable Identifier
R-HSA-6799221
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
azurophil granule lumen
Synonyms
PKC-delta fragment (330-676)
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule lumen proteins (Homo sapiens)
Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)
PRKCD(330-676) [azurophil granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q05655 PRKCD
Gene Names
PRKCD, PKCD
Chain
chain:1-676, chain:1-329, chain:330-676
Reference Genes
BioGPS Gene:5580 PRKCD
COSMIC (genes):PRKCD PRKCD
CTD Gene:5580 PRKCD
dbSNP Gene:5580 PRKCD
ENSEMBL:ENSG00000163932 PRKCD
ENSEMBL_homo_sapiens_GENE:ENSG00000163932.16 PRKCD
HGNC:9399 PRKCD
KEGG Gene (Homo sapiens):5580 PRKCD
Monarch:5580 PRKCD
NCBI Gene:5580 PRKCD
OMIM:176977 PRKCD
UCSC:Q05655 PRKCD
Reference Transcript
RefSeq:XM_006713259.2 PRKCD
RefSeq:NM_212539.1 PRKCD
RefSeq:XM_017006856.1 PRKCD
RefSeq:XM_017006855.1 PRKCD
RefSeq:NM_006254.3 PRKCD
RefSeq:NM_001316327.1 PRKCD
Other Identifiers
11727841_a_at
11736573_a_at
16941781
1810_s_at
202545_PM_at
202545_at
2624292
2624294
2624303
2624304
2624305
2624306
2624307
2624308
2624310
2624311
2624313
2624314
2624316
2624318
2624319
2624320
2624323
2624327
2624329
2624330
2624331
2624333
2624334
2624335
32046_at
5580
8080487
A_14_P104518
A_14_P138877
A_23_P144054
D10495_at
GE57042
GO:0000166
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004697
GO:0004699
GO:0004713
GO:0004715
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005764
GO:0005768
GO:0005773
GO:0005783
GO:0005829
GO:0005886
GO:0005911
GO:0006468
GO:0006629
GO:0006886
GO:0006913
GO:0006915
GO:0006954
GO:0006974
GO:0007010
GO:0007049
GO:0007155
GO:0007165
GO:0008047
GO:0008631
GO:0010469
GO:0012501
GO:0012505
GO:0016020
GO:0016064
GO:0016071
GO:0016192
GO:0016301
GO:0016310
GO:0016363
GO:0016740
GO:0018105
GO:0018107
GO:0019899
GO:0019901
GO:0023021
GO:0023052
GO:0030837
GO:0031410
GO:0032079
GO:0032091
GO:0032147
GO:0032930
GO:0032956
GO:0034351
GO:0034644
GO:0035307
GO:0035556
GO:0035578
GO:0036019
GO:0036211
GO:0038096
GO:0042060
GO:0042100
GO:0042119
GO:0042307
GO:0042742
GO:0043226
GO:0043407
GO:0043488
GO:0043560
GO:0043687
GO:0046627
GO:0046872
GO:0048471
GO:0048870
GO:0050728
GO:0050732
GO:0050821
GO:0050896
GO:0051490
GO:0060326
GO:0061024
GO:0065003
GO:0070062
GO:0070301
GO:0071447
GO:0080090
GO:0090331
GO:0090398
GO:0098542
GO:0098772
GO:0106310
GO:0140096
GO:1900163
GO:1901135
GO:1904385
GO:2000303
GO:2000304
GO:2000753
GO:2000755
GO:2001235
HMNXSV003051624
ILMN_1682813
ILMN_1801105
PH_hs_0009356
TC03000348.hg
TC03002349.hg
g5453969_3p_at
Participates
as a member of
Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)
Other forms of this molecule
PRKCD(1-676) [nucleoplasm]
PRKCD(330-676) [extracellular region]
PRKCD(1-329) [extracellular region]
PRKCD(1-329) [azurophil granule lumen]
p-T507-PRKCD [cytosol]
p-T507,S645,S664-PRKCD [cytosol]
active p-T507,S645,S664-PRKCD [plasma membrane]
p-T507,S645,S664-PRKCD(1-676) [plasma membrane]
PRKCD(330-676) [cytosol]
PRKCD(1-329) [cytosol]
PRKCD [cytosol]
Inferred To
PRKCD(330-676) [azurophil granule lumen]
(Bos taurus)
PRKCD(330-676) [azurophil granule lumen]
(Caenorhabditis elegans)
PRKCD(330-676) [azurophil granule lumen]
(Danio rerio)
PRKCD(330-676) [azurophil granule lumen]
(Dictyostelium discoideum)
PRKCD(330-676) [azurophil granule lumen]
(Drosophila melanogaster)
PRKCD(330-676) [azurophil granule lumen]
(Mus musculus)
PRKCD(330-676) [azurophil granule lumen]
(Rattus norvegicus)
PRKCD(330-676) [azurophil granule lumen]
(Saccharomyces cerevisiae)
PRKCD(330-676) [azurophil granule lumen]
(Schizosaccharomyces pombe)
PRKCD(330-676) [azurophil granule lumen]
(Sus scrofa)
PRKCD(330-676) [azurophil granule lumen]
(Xenopus tropicalis)
Homologues of PRKCD(330-676) [azurophil granule lumen]
(Dictyostelium discoideum)
Homologues of PRKCD(330-676) [azurophil granule lumen]
(Schizosaccharomyces pombe)
PRKCD [azurophil granule lumen]
(Canis familiaris)
PRKCD [azurophil granule lumen]
(Gallus gallus)
Cross References
RefSeq
NP_001303256.1
,
XP_016862344.1
,
XP_016862345.1
,
NP_006245.2
,
NP_997704.1
,
XP_006713322.1
ZINC - World Drugs
KPCD_HUMAN
Guide to Pharmacology - Targets
1485
OpenTargets
ENSG00000163932
ZINC - FDA approved
KPCD_HUMAN
ZINC - Substances
KPCD_HUMAN
ZINC - Biogenic
KPCD_HUMAN
ZINC target
Q05655
PRO
Q05655
PDB
1YRK
,
2YUU
ZINC - Investigational
KPCD_HUMAN
ZINC - Metabolites
KPCD_HUMAN
IntEnz
2.7.10.2
,
2.7.11.13
HPA
ENSG00000163932-PRKCD
GeneCards
Q05655
Ensembl
ENST00000652449
,
ENSG00000163932
,
ENST00000330452
,
ENSP00000331602
,
ENST00000654719
,
ENST00000394729
,
ENSP00000498623
,
ENST00000650739
,
ENSP00000378217
,
ENSP00000498400
,
ENSP00000499558
Pharos - Targets
Q05655
ZINC - Predictions - Purchasable
KPCD_HUMAN
Orphanet
22033
HMDB Protein
HMDBP01847
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.737
5
UniProt:P24001-2 IL32
0.728
7
UniProt:P11388 TOP2A
3
TOP2A [nucleoplasm]
(R-HSA-1362276)
polySUMO2,3-TOP2A [nucleoplasm]
(R-HSA-4641298)
monoSUMO1-K-TOP2A [nucleoplasm]
(R-HSA-4641367)
0.679
10
UniProt:Q9H5V8 CDCP1
0.675
7
UniProt:Q9BXL7 CARD11
5
p-S559,S644,S652-CARD11 [plasma membrane]
(R-HSA-1168564)
CARD11 [plasma membrane]
(R-HSA-2685592)
p-S559,S652-CARD11 [cytosol]
(R-HSA-2685625)
CARD11 [cytosol]
(R-HSA-202161)
p-S552-CARD11 [cytosol]
(R-HSA-202438)
0.619
7
UniProt:P17677 GAP43
2
PALM-C3,4-GAP43 [plasma membrane]
(R-HSA-8933482)
GAP43 [plasma membrane]
(R-HSA-452888)
0.602
4
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.602
4
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q9UBQ0-2 VPS29
0.556
3
UniProt:P19878 NCF2
2
p-T233-NCF2 [phagolysosome]
(R-HSA-1996211)
NCF2 [cytosol]
(R-HSA-1222600)
0.544
3
UniProt:Q04759 PRKCQ
9
PRKCQ [photoreceptor disc membrane]
(R-HSA-2648997)
p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane]
(R-HSA-2685606)
PRKCQ(1-354) [cytosol]
(R-HSA-212526)
PRKCQ(355-706) [cytosol]
(R-HSA-212514)
PRKCQ [cytosol]
(R-HSA-58216)
PRKQC closed conformation [cytosol]
(R-HSA-202185)
PRKCQ [plasma membrane]
(R-HSA-202346)
p-Y90-PRKCQ [plasma membrane]
(R-HSA-202395)
p-Y90,T538,S676,S695-PRKCQ [plasma membrane]
(R-HSA-202152)
0.527
2
UniProt:Q8N5V2 NGEF
2
NGEF [cytosol]
(R-HSA-3006800)
p-Y179-NGEF [cytosol]
(R-HSA-3928441)
0.527
2
UniProt:P05771 PRKCB
5
PRKCB [plasma membrane]
(R-HSA-156467)
PRKCB [cytosol]
(R-HSA-58198)
p-T500-PRKCB [cytosol]
(R-HSA-5218728)
p-T500,T642,S661-PRKCB [cytosol]
(R-HSA-5218706)
p-T500,T642,S661-PRKCB [nucleoplasm]
(R-HSA-5223294)
0.527
2
UniProt:P57078 RIPK4
0.527
2
UniProt:P29353 SHC1
5
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
SHC1 [cytosol]
(R-HSA-74680)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
0.527
3
UniProt:C6GKH1 C6GKH1
0.463
3
UniProt:Q12816 TROP
0.463
2
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