Reactome | POLE [nucleoplasm]

POLE [nucleoplasm]

Stable Identifier

R-HSA-68473

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA polymerase epsilon, catalytic subunit A , DNA polymerase II subunit A

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Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- Base Excision Repair (Homo sapiens)
  - Resolution of Abasic Sites (AP sites) (Homo sapiens)
    - Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Homo sapiens)
      - PCNA-Dependent Long Patch Base Excision Repair (Homo sapiens)
        
        FEN1 bound to PCNA and APEX1 cleaves flap ssDNA (Homo sapiens)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        LIG1 binds APEX1 and PCNA at SSB (Homo sapiens)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        LIG1 bound to APEX1 and PCNA ligates SSB (Homo sapiens)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA (Homo sapiens)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Homo sapiens)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE-mediated DNA strand displacement synthesis (Homo sapiens)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
- DNA Damage Bypass (Homo sapiens)
  - Recognition of DNA damage by PCNA-containing replication complex (Homo sapiens)
    - PCNA-containing replication complex binds damaged dsDNA (Homo sapiens)
      - PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
      - PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Homo sapiens)
      - POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Homo sapiens)
      - PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
  - Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Homo sapiens)
    - Termination of translesion DNA synthesis (Homo sapiens)
      - POLD,POLE binds deISGylated PCNA after TLS (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
      - POLD,POLE complete replication of damaged DNA after TLS (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        D-loop extension by DNA polymerases (Homo sapiens)
        
        PCNA:POLD,POLE,POLH,POLK:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
- Nucleotide Excision Repair (Homo sapiens)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
    - Dual Incision in GG-NER (Homo sapiens)
      - 3'-incision of DNA by ERCC5 (XPG) in GG-NER (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
      - DNA polymerases delta, epsilon or kappa bind the GG-NER site (Homo sapiens)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE,POLK [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
    - Gap-filling DNA repair synthesis and ligation in GG-NER (Homo sapiens)
      - Ligation of newly synthesized repair patch to incised DNA in GG-NER (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
    - Dual incision in TC-NER (Homo sapiens)
      - 3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
        
        POLD,POLE,POLK [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Homo sapiens)
        
        PCNA:POLD,POLE [nucleoplasm] (Homo sapiens)
        
        POLD,POLE [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon [nucleoplasm] (Homo sapiens)
        
        POLE [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q07864 POLE

Gene Names

POLE, POLE1

Chain

chain:1-2286

Reference Genes

BioGPS Gene:5426 POLE

COSMIC (genes):POLE POLE

CTD Gene:5426 POLE

dbSNP Gene:5426 POLE

ENSEMBL:ENSG00000177084 POLE

ENSEMBL_homo_sapiens_GENE:ENSG00000177084.19 POLE

HGNC:9177 POLE

KEGG Gene (Homo sapiens):5426 POLE

Monarch:5426 POLE

NCBI Gene:5426 POLE

OMIM:174762 POLE

UCSC:Q07864 POLE

Reference Transcript

RefSeq:NM_006231.3 POLE

Other Identifiers

11719750_s_at

16772625

1726_at

216026_PM_s_at

216026_s_at

3479182

3479183

3479184

3479185

3479186

3479187

3479188

3479189

3479190

3479194

3479198

3479202

3479204

3479206

3479207

3479208

3479212

3479213

3479215

3479217

3479219

3479220

3479221

3479222

3479223

3479224

3479226

3479229

3479230

3479231

3479234

3479235

3479237

3479239

3479240

3479241

3479242

3479243

3479244

3479245

3479246

3479249

3479251

3479256

3479258

3479259

3479260

3479263

3479264

3479265

3479266

3479267

3479269

3479270

3479271

3479272

3479273

3479275

3479277

3479279

3479280

40450_at

40451_at

5426

7967736

A_23_P159355

A_24_P918387

A_33_P3255794

A_33_P3695548

GE57596

GO:0000082

GO:0000166

GO:0000228

GO:0000278

GO:0000731

GO:0003676

GO:0003677

GO:0003682

GO:0003824

GO:0003887

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005886

GO:0006260

GO:0006261

GO:0006272

GO:0006281

GO:0006287

GO:0006297

GO:0006974

GO:0008270

GO:0008310

GO:0008622

GO:0016740

GO:0016779

GO:0016787

GO:0031981

GO:0043226

GO:0045004

GO:0046872

GO:0048568

GO:0048856

GO:0051536

GO:0051539

GO:0071897

GO:0140097

HMNXSV003041851

Hs.166846.1.S1_3p_a_at

ILMN_1728199

PH_hs_0025509

TC12002153.hg

Participates

as a component of

DNA polymerase epsilon [nucleoplasm] (Homo sapiens)

Inferred To

POLE [nucleoplasm] (Bos taurus)

POLE [nucleoplasm] (Canis familiaris)

POLE [nucleoplasm] (Dictyostelium discoideum)

POLE [nucleoplasm] (Drosophila melanogaster)

POLE [nucleoplasm] (Gallus gallus)

POLE [nucleoplasm] (Mus musculus)

POLE [nucleoplasm] (Plasmodium falciparum)

POLE [nucleoplasm] (Saccharomyces cerevisiae)

POLE [nucleoplasm] (Schizosaccharomyces pombe)

POLE [nucleoplasm] (Sus scrofa)

Pole [nucleoplasm] (Rattus norvegicus)

Ghost homologue of POLE [nucleoplasm] (Xenopus tropicalis)

pole-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_006222.2

OpenTargets

ENSG00000177084

GeneCards

Q07864

HPA

ENSG00000177084-POLE

Ensembl

ENSP00000322570, ENST00000320574, ENSG00000177084

PRO

Q07864

Pharos - Targets

Q07864

Orphanet

22180

PDB

5VBN, 7PLO, 7PFO

HMDB Protein

HMDBP00961

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.564	2

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