Reactome | PDHA1 [mitochondrial matrix]

PDHA1 [mitochondrial matrix]

Stable Identifier

R-HSA-69966

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

pyruvate dehydrogenase E1 alpha apoprotein, ODPA_HUMAN, Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial precursor , PDHE1-A type I

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Nuclear Receptors (Homo sapiens)
  - Signaling by Retinoic Acid (Homo sapiens)
    - PDK isozymes phosphorylate PDHC subunit E1 (Homo sapiens)
      - PDH complex [mitochondrial matrix] (Homo sapiens)
        
        PDH E1 [mitochondrial matrix] (Homo sapiens)
        
        PDHA1,2 [mitochondrial matrix] (Homo sapiens)
        
        PDHA1 [mitochondrial matrix] (Homo sapiens)
      - p-lipo-PDH [mitochondrial matrix] (Homo sapiens)
        
        PDH E1 [mitochondrial matrix] (Homo sapiens)
        
        PDHA1,2 [mitochondrial matrix] (Homo sapiens)
        
        PDHA1 [mitochondrial matrix] (Homo sapiens)
        
        phosphorylated pyruvate dehydrogenase E1 complex [mitochondrial matrix] (Homo sapiens)
        
        PDH E1 [mitochondrial matrix] (Homo sapiens)
        
        PDHA1,2 [mitochondrial matrix] (Homo sapiens)
        
        PDHA1 [mitochondrial matrix] (Homo sapiens)

External Reference Information

External Reference

UniProt:P08559 PDHA1

Gene Names

PDHA1, PHE1A

Chain

transit peptide:1-29, chain:30-390

Reference Genes

BioGPS Gene:5160 PDHA1

COSMIC (genes):PDHA1 PDHA1

CTD Gene:5160 PDHA1

dbSNP Gene:5160 PDHA1

ENSEMBL:ENSG00000131828 PDHA1

ENSEMBL_homo_sapiens_GENE:ENSG00000131828.14 PDHA1

HGNC:8806 PDHA1

KEGG Gene (Homo sapiens):5160 PDHA1

Monarch:5160 PDHA1

NCBI Gene:5160 PDHA1

OMIM:300502 PDHA1

UCSC:P08559 PDHA1

Reference Transcript

Other Identifiers

11717482_at

11717483_a_at

11717484_x_at

11747772_x_at

11753896_a_at

1555864_PM_s_at

1555864_s_at

17101957

200979_PM_at

200979_at

200980_PM_s_at

200980_s_at

38638_at

3970867

3970868

3970869

3970872

3970873

3970874

3970875

3970878

3970881

3970885

3970887

3970889

3970891

3970893

3970894

3970895

3970936

3970938

5160

8166335

A_23_P251095

D90084_at

GE79463

GE86300

GO:0003824

GO:0004738

GO:0004739

GO:0005515

GO:0005634

GO:0005730

GO:0005739

GO:0005759

GO:0005967

GO:0005975

GO:0006006

GO:0006086

GO:0006090

GO:0006091

GO:0006099

GO:0006790

GO:0016491

GO:0016624

GO:0034604

GO:0043226

GO:0043231

GO:0045254

GO:0055086

GO:1901135

GO:1902494

HMNXSV003001760

Hs.1023.0.S2_3p_at

ILMN_1772369

PH_hs_0000131

PH_hs_0035314

TC0X000092.hg

g4505684_3p_s_at

Participates

as a member of

Inferred To

PDHA2 [mitochondrial matrix] (Gallus gallus)

PDA1 [mitochondrial matrix] (Saccharomyces cerevisiae)

Pdha1 [mitochondrial matrix] (Mus musculus)

Pdha [mitochondrial matrix] (Drosophila melanogaster)

pdhA [mitochondrial matrix] (Dictyostelium discoideum)

pda1 [mitochondrial matrix] (Schizosaccharomyces pombe)

PDHA1 [mitochondrial matrix] (Bos taurus)

PDHA1 [mitochondrial matrix] (Caenorhabditis elegans)

PDHA1 [mitochondrial matrix] (Canis familiaris)

PDHA1 [mitochondrial matrix] (Sus scrofa)

Pdha1l1 [mitochondrial matrix] (Rattus norvegicus)

Cross References

RefSeq

NP_001166927.1, NP_001166925.1, NP_000275.1, NP_001166926.1

OpenTargets

ENSG00000131828

GeneCards

P08559

HPA

ENSG00000131828-PDHA1

Ensembl

ENST00000422285, ENSP00000394382, ENSP00000406473, ENST00000540249, ENST00000355808, ENSP00000348062, ENST00000423505, ENSG00000131828, ENSP00000440761

PRO

P08559

Pharos - Targets

P08559

Orphanet

16631

HMDB Protein

HMDBP00046

PDB

6CFO, 1NI4, 6CER, 3EXI, 2OZL, 3EXH, 3EXF, 3EXG, 3EXE

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42229 STAT5A	4	STAT5A [nucleoplasm] (R-HSA-9701901) p-Y694-STAT5A [nucleoplasm] (R-HSA-507995) p-Y694-STAT5A [cytosol] (R-HSA-507936) STAT5A [cytosol] (R-HSA-380747)	0.643	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.519	5
UniProt:Q16891 IMMT	1	IMMT (MIC60) [mitochondrial inner membrane] (R-HSA-8949569)	0.499	4