Reactome | TKT [cytosol]

TKT [cytosol]

Stable Identifier

R-HSA-71321

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

transketolase monomer, TKT_HUMAN, Transketolase , TK

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        NFE2L2 regulates pentose phosphate pathway genes (Homo sapiens)
        
        NFE2L2-dependent TKT gene expression (Homo sapiens)
        
        TKT dimer [cytosol] (Homo sapiens)
        
        TKT [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P29401 TKT

Gene Names

TKT

Chain

chain:1-623

Reference Genes

BioGPS Gene:7086 TKT

COSMIC (genes):TKT TKT

CTD Gene:7086 TKT

dbSNP Gene:7086 TKT

ENSEMBL:ENSG00000163931 TKT

HGNC:11834 TKT

KEGG:hsa:7086 TKT

Monarch:7086 TKT

NCBI Gene:7086 TKT

OMIM:606781 TKT

UCSC:P29401 TKT

Reference Transcript

Other Identifiers

11719934_a_at

11754945_x_at

11756952_a_at

16955064

208699_PM_x_at

208699_x_at

208700_3p_s_at

208700_PM_s_at

208700_s_at

228205_PM_at

228205_at

2676670

2676672

2676673

2676674

2676675

2676676

2676677

2676678

2676679

2676680

2676681

2676682

2676683

2676684

2676685

2676686

2676687

2676688

2676690

2676691

2676692

2676693

2676694

2676695

2676696

2676697

2676698

2676699

2676700

2676701

2676702

2676704

2676705

2676706

2676714

2676715

38789_at

47520_at

59913_at

7086

8088106

A_23_P92082

GE86737

GO:0000287

GO:0003824

GO:0004802

GO:0005509

GO:0005515

GO:0005654

GO:0005737

GO:0005777

GO:0005789

GO:0005829

GO:0006091

GO:0006098

GO:0009052

GO:0016604

GO:0016740

GO:0030976

GO:0031982

GO:0040008

GO:0042803

GO:0043226

GO:0046166

GO:0046872

GO:0055086

GO:0070062

GO:1901135

GO:1901159

HMNXSV003002516

HMNXSV003007084

Hs.89643.0.A1_3p_a_at

Hs.89643.0.A1_3p_x_at

Hs.89643.1.A1_3p_at

ILMN_1736597

L12711_s_at

PH_hs_0005008

TC03001466.hg

g388890_3p_a_at

g388890_3p_x_at

Participates

as a component of

TKT dimer [cytosol] (Homo sapiens)

Inferred To

tkt-1 [cytosol] (Caenorhabditis elegans)

Dmel\CG5103 [cytosol] (Drosophila melanogaster)

Homologues of TKT [cytosol] (Drosophila melanogaster)

TKT [cytosol] (Bos taurus)

TKT [cytosol] (Canis familiaris)

TKT [cytosol] (Mus musculus)

TKT [cytosol] (Rattus norvegicus)

TKT [cytosol] (Sus scrofa)

anon-WO0118547.344 [cytosol] (Drosophila melanogaster)

tkt [cytosol] (Xenopus tropicalis)

TKTL1 [cytosol] (Gallus gallus)

Cross References

RefSeq

XP_011532356.1, NP_001244957.1, NP_001128527.1, NP_001055.1

OpenTargets

ENSG00000163931

ENSEMBL

ENSP00000417773, ENSP00000405455, ENST00000462138, ENST00000423516, ENSP00000391481, ENST00000423525

ZINC - Substances

TKT_HUMAN

ZINC target

P29401

PRO

P29401

GlyGen

P29401

PDB

6HA3, 3OOY, 6HAD, 4KXY, 4KXU, 3MOS, 4KXW, 8WAA, 8WA9, 4KXX, 4KXV, 6RJB, 8WA8

HPA

ENSG00000163931-TKT

Pharos - Targets

P29401

Orphanet

TKT

ZINC - Predictions - Purchasable

TKT_HUMAN

HMDB Protein

HMDBP00805

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	9
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.569	10
UniProt:P45983 MAPK8	3	MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.527	2
UniProt:Q9NVC6 MED17	1	MED17 [nucleoplasm] (R-HSA-212401)	0.527	2
UniProt:O60294 LCMT2	1	LCMT2 [cytoplasm] (R-HSA-6782869)	0.527	2
UniProt:Q8NEZ3 WDR19	2	WDR19 [ciliary tip] (R-HSA-5625347) WDR19 [cilium] (R-HSA-5610446)	0.527	2

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