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hSLU7 [nucleoplasm]
Stable Identifier
R-HSA-72073
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Pre-mRNA splicing factor SLU7, SLU7_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Transcription Termination (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
hSLU7 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
hSLU7 [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
hSLU7 [nucleoplasm] (Homo sapiens)
hSLU7 [nucleoplasm] (Homo sapiens)
NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Homo sapiens)
NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
hSLU7 [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
hSLU7 [nucleoplasm] (Homo sapiens)
mRNA 3'-end processing (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
hSLU7 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
hSLU7 [nucleoplasm] (Homo sapiens)
TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
hSLU7 [nucleoplasm] (Homo sapiens)
Spliced mRNP [nucleoplasm] (Homo sapiens)
hSLU7 [nucleoplasm] (Homo sapiens)
mRNA polyadenylation (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
hSLU7 [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
hSLU7 [nucleoplasm] (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Formation of the Spliceosomal C* complex (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
hSLU7 [nucleoplasm] (Homo sapiens)
hSLU7 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
hSLU7 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
hSLU7 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
hSLU7 [nucleoplasm] (Homo sapiens)
hSLU7 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95391 SLU7
Gene Names
SLU7
Chain
initiator methionine:, chain:2-586
Reference Genes
BioGPS Gene:10569 SLU7
COSMIC (genes):SLU7 SLU7
CTD Gene:10569 SLU7
dbSNP Gene:10569 SLU7
ENSEMBL:ENSG00000164609 SLU7
ENSEMBL_homo_sapiens_GENE:ENSG00000164609.10 SLU7
HGNC:16939 SLU7
KEGG Gene (Homo sapiens):10569 SLU7
Monarch:10569 SLU7
NCBI Gene:10569 SLU7
OMIM:605974 SLU7
UCSC:O95391 SLU7
Reference Transcript
RefSeq:NM_006425.4 SLU7
RefSeq:XM_011534418.2 SLU7
Other Identifiers
10569
11724469_at
11757348_s_at
17002402
227990_PM_at
227990_at
231718_PM_at
231718_at
2884659
2884660
2884661
2884663
2884664
2884666
2884667
2884669
2884671
2884673
2884674
2884675
2884676
2884678
2884679
2884680
2884682
2884683
2884684
2884688
43358_r_at
48520_at
52217_s_at
57018_at
8115606
A_23_P110704
A_24_P174824
A_24_P377328
GE79256
GE88616
GO:0000375
GO:0000380
GO:0000386
GO:0000389
GO:0000398
GO:0003723
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005681
GO:0005737
GO:0005829
GO:0006397
GO:0006886
GO:0008270
GO:0008380
GO:0016020
GO:0016071
GO:0016607
GO:0030532
GO:0030628
GO:0034605
GO:0043226
GO:0043231
GO:0046872
GO:0065003
GO:0071013
GO:0140098
HMNXSV003044116
Hs.76325.0.A1_3p_at
Hs.76325.2.A1_3p_at
ILMN_1685369
PH_hs_0020409
TC05002010.hg
TC05003330.hg
Participates
as an input of
Formation of the Spliceosomal C* complex (Homo sapiens)
as a component of
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
Spliced mRNP [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
as an output of
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
Inferred To
Slu7 [nucleoplasm]
(Drosophila melanogaster)
Slu7 [nucleoplasm]
(Mus musculus)
Slu7 [nucleoplasm]
(Rattus norvegicus)
slu7 [nucleoplasm]
(Danio rerio)
slu7 [nucleoplasm]
(Dictyostelium discoideum)
slu7 [nucleoplasm]
(Schizosaccharomyces pombe)
slu7 [nucleoplasm]
(Xenopus tropicalis)
SLU7 [nucleoplasm]
(Bos taurus)
SLU7 [nucleoplasm]
(Canis familiaris)
SLU7 [nucleoplasm]
(Sus scrofa)
hSLU7 [nucleoplasm]
(Caenorhabditis elegans)
hSLU7 [nucleoplasm]
(Gallus gallus)
hSLU7 [nucleoplasm]
(Plasmodium falciparum)
Cross References
RefSeq
XP_011532720.1
,
NP_006416.3
OpenTargets
ENSG00000164609
GeneCards
O95391
HPA
ENSG00000164609-SLU7
Ensembl
ENSP00000297151
,
ENST00000297151
,
ENSG00000164609
PRO
O95391
Pharos - Targets
O95391
PDB
5XJC
,
6ICZ
,
7W5A
,
8C6J
,
6QDV
,
7W5B
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H2H8 PPIL3
1
PPIL3 [nucleoplasm]
(R-HSA-8952110)
0.801
7
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.718
6
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.556
3
UniProt:Q8NHQ1 CEP70
1
CEP70 [cytosol]
(R-HSA-380257)
0.556
3
UniProt:Q9UBB4 ATX10
0.556
3
UniProt:Q13155 AIMP2
1
AIMP2 [cytosol]
(R-HSA-379576)
0.556
3
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:Q13643 FHL3
0.556
3
UniProt:P23508 CRCM
0.556
3
UniProt:Q9BRK4 LZTS2
0.556
3
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.556
3
UniProt:Q96N21 AP4AT
0.556
3
UniProt:Q9NVV9 THAP1
0.556
3
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.556
3
UniProt:Q17RB8 LONRF1
1
LONRF1 [cytosol]
(R-HSA-8850905)
0.556
3
UniProt:Q8NI38 IKBD
0.556
3
UniProt:Q4G0R1 Q4G0R1
0.556
3
UniProt:Q9H4E7 DEF6
1
DEF6 [cytosol]
(R-HSA-9691487)
0.556
3
UniProt:Q8WXH2 JPH3
0.556
3
UniProt:P0DTD1-PRO_0000449629 REP
0.527
2
UniProt:Q6P2Q9 PRPF8
1
PRPF8 [nucleoplasm]
(R-HSA-83810)
0.508
2
UniProt:Q13435 SF3B2
1
SF3B2 [nucleoplasm]
(R-HSA-71971)
0.508
2
UniProt:O43395 PRPF3
1
PRPF3 [nucleoplasm]
(R-HSA-6806806)
0.508
2
UniProt:Q9BZ95 NSD3
1
WHSC1L1 [nucleoplasm]
(R-HSA-1183230)
0.508
2
UniProt:O75152 ZC3H11A
1
ZC3H11A [nucleoplasm]
(R-HSA-8850659)
0.483
2
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