Reactome | CAD [cytosol]

CAD [cytosol]

Stable Identifier

R-HSA-73452

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, CAD protein (Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)), Glutamine-dependent carbamoyl-phosphate synthase , Aspartate carbamoyltransferase , Dihydroorotase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P27708 CAD

Gene Names

CAD

Chain

initiator methionine:, chain:2-2225

Reference Genes

BioGPS Gene:790 CAD

COSMIC (genes):CAD CAD

CTD Gene:790 CAD

dbSNP Gene:790 CAD

ENSEMBL:ENSG00000084774 CAD

ENSEMBL_homo_sapiens_GENE:ENSG00000084774.14 CAD

HGNC:1424 CAD

KEGG Gene (Homo sapiens):790 CAD

Monarch:790 CAD

NCBI Gene:790 CAD

OMIM:114010 CAD

UCSC:P27708 CAD

Reference Transcript

Other Identifiers

11718531_a_at

16878137

202715_PM_at

202715_at

2474342

2474343

2474344

2474345

2474346

2474348

2474349

2474350

2474351

2474352

2474353

2474354

2474355

2474356

2474357

2474358

2474359

2474360

2474363

2474364

2474365

2474367

2474369

2474370

2474372

2474373

2474375

2474376

2474377

2474380

2474381

2474382

2474383

2474384

2474385

2474386

2474387

2474388

2474391

2474392

2474394

2474395

2474396

2474397

2474398

2474399

2474401

2474402

2474405

2474406

32031_at

749_at

790

8040843

A_14_P113919

A_23_P40049

D78586_at

GE57302

GO:0000166

GO:0001889

GO:0003824

GO:0004070

GO:0004087

GO:0004088

GO:0004151

GO:0004359

GO:0004672

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0006207

GO:0006221

GO:0006225

GO:0006228

GO:0006520

GO:0006541

GO:0006805

GO:0006807

GO:0007507

GO:0007565

GO:0007595

GO:0008152

GO:0008270

GO:0014075

GO:0016020

GO:0016363

GO:0016597

GO:0016740

GO:0016743

GO:0016787

GO:0016810

GO:0016812

GO:0016874

GO:0018107

GO:0019240

GO:0019899

GO:0022414

GO:0031000

GO:0031100

GO:0032868

GO:0032991

GO:0033574

GO:0036211

GO:0042594

GO:0042802

GO:0042995

GO:0043025

GO:0043195

GO:0043226

GO:0044205

GO:0044238

GO:0044281

GO:0046777

GO:0046872

GO:0048856

GO:0051414

GO:0055086

GO:0070062

GO:0070335

GO:0071364

GO:0071466

GO:0072528

GO:0140096

GO:1901135

HMNXSV003022803

ILMN_1810992

PH_hs_0024275

TC02000168.hg

g4757895_3p_at

Participates

as a component of

CAD hexamer [cytosol] (Homo sapiens)

Inferred To

cad [cytosol] (Xenopus tropicalis)

Cad [cytosol] (Rattus norvegicus)

CAD [cytosol] (Bos taurus)

CAD [cytosol] (Caenorhabditis elegans)

CAD [cytosol] (Canis familiaris)

CAD [cytosol] (Dictyostelium discoideum)

CAD [cytosol] (Drosophila melanogaster)

CAD [cytosol] (Mus musculus)

CAD [cytosol] (Plasmodium falciparum)

CAD [cytosol] (Saccharomyces cerevisiae)

CAD [cytosol] (Schizosaccharomyces pombe)

CAD [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_004332.2, NP_001293008.1

OpenTargets

ENSG00000084774

ZINC - Substances

PYR1_HUMAN

ZINC target

P27708

PRO

P27708

PDB

6HFP, 6HFU, 4C6L, 8PBG, 5G1P, 4C6K, 6HG1, 6HFQ, 4C6J, 8GW0, 8PBH, 8GVZ, 8PBQ, 5YNZ, 4BY3, 8PBI, 4C6Q, 6HFR, 4C6O, 4C6N, 8PBJ, 4C6C, 4C6B, 8PBP, 8PBK, 8PBT, 8PBU, 6HFF, 6HFK, 5G1O, 8PBM, 6HFD, 5G1N, 6HFH, 6HFL, 4C6I, 4C6F, 4C6P, 8PBR, 6HFI, 4C6D, 4C6E, 6HFN, 8PBN, 6HFS, 8PBE, 8PBS, 6HFJ, 6HFE, 4C6M

IntEnz

3.5.2.3, 3.5.1.2

GeneCards

P27708

HPA

ENSG00000084774-CAD

Ensembl

ENSP00000264705, ENST00000264705, ENSG00000084774

Pharos - Targets

P27708

Orphanet

23690

ZINC - Predictions - Purchasable

PYR1_HUMAN

HMDB Protein

HMDBP03298

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.725	4
UniProt:Q99558 MAP3K14	5	p-T559-MAP3K14 [cytosol] (R-HSA-5668531) K48polyUb-NIK [cytosol] (R-HSA-5668525) Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187)	0.669	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	19
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.564	2
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	3