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CAD [cytosol]
Stable Identifier
R-HSA-73452
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, CAD protein (Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)), Glutamine-dependent carbamoyl-phosphate synthase , Aspartate carbamoyltransferase , Dihydroorotase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Nucleotide biosynthesis (Homo sapiens)
Pyrimidine biosynthesis (Homo sapiens)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Homo sapiens)
CAD hexamer [cytosol] (Homo sapiens)
CAD [cytosol] (Homo sapiens)
CAD hexamer transforms CAP to N-carb-L-Asp (Homo sapiens)
CAD hexamer [cytosol] (Homo sapiens)
CAD [cytosol] (Homo sapiens)
CAD hexamer transforms L-Gln to CAP (Homo sapiens)
CAD hexamer [cytosol] (Homo sapiens)
CAD [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P27708 CAD
Gene Names
CAD
Chain
initiator methionine:1, chain:2-2225
Reference Genes
BioGPS Gene:790 CAD
COSMIC (genes):CAD CAD
CTD Gene:790 CAD
dbSNP Gene:790 CAD
ENSEMBL:ENSG00000084774.14 CAD
HGNC:1424 CAD
KEGG Gene (Homo sapiens):790 CAD
Monarch:790 CAD
NCBI Gene:790 CAD
OMIM:114010 CAD
UCSC:P27708 CAD
Reference Transcript
RefSeq:NM_004341.4 CAD
RefSeq:NM_001306079.1 CAD
Other Identifiers
11718531_a_at
16878137
202715_PM_at
202715_at
2474342
2474343
2474344
2474345
2474346
2474348
2474349
2474350
2474351
2474352
2474353
2474354
2474355
2474356
2474357
2474358
2474359
2474360
2474363
2474364
2474365
2474367
2474369
2474370
2474372
2474373
2474375
2474376
2474377
2474380
2474381
2474382
2474383
2474384
2474385
2474386
2474387
2474388
2474391
2474392
2474394
2474395
2474396
2474397
2474398
2474399
2474401
2474402
2474405
2474406
32031_at
749_at
790
8040843
A_14_P113919
A_23_P40049
D78586_at
GE57302
GO:0000166
GO:0003824
GO:0004070
GO:0004088
GO:0004151
GO:0004672
GO:0005524
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0006207
GO:0006221
GO:0006225
GO:0006228
GO:0006520
GO:0006541
GO:0006807
GO:0008152
GO:0008270
GO:0016020
GO:0016363
GO:0016597
GO:0016740
GO:0016743
GO:0016787
GO:0016810
GO:0016812
GO:0016874
GO:0018107
GO:0018130
GO:0019240
GO:0019899
GO:0036094
GO:0036211
GO:0042802
GO:0042995
GO:0043025
GO:0043195
GO:0043226
GO:0044205
GO:0044238
GO:0044271
GO:0044281
GO:0046777
GO:0046872
GO:0055086
GO:0070062
GO:0070335
GO:0140096
GO:1901135
GO:1901566
HMNXSV003022803
ILMN_1810992
PH_hs_0024275
TC02000168.hg
g4757895_3p_at
Participates
as a component of
CAD hexamer [cytosol] (Homo sapiens)
Inferred To
cad [cytosol]
(Xenopus tropicalis)
Cad [cytosol]
(Rattus norvegicus)
URA2 [cytosol]
(Saccharomyces cerevisiae)
CAD [cytosol]
(Bos taurus)
CAD [cytosol]
(Caenorhabditis elegans)
CAD [cytosol]
(Canis familiaris)
CAD [cytosol]
(Danio rerio)
CAD [cytosol]
(Dictyostelium discoideum)
CAD [cytosol]
(Drosophila melanogaster)
CAD [cytosol]
(Mus musculus)
CAD [cytosol]
(Plasmodium falciparum)
CAD [cytosol]
(Sus scrofa)
ura1 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_004332.2
,
NP_001293008.1
OpenTargets
ENSG00000084774
ZINC - Substances
PYR1_HUMAN
ZINC target
P27708
PRO
P27708
PDB
5G1O
,
4C6K
,
6HFF
,
6HFS
,
6HFH
,
6HFR
,
4C6L
,
5G1P
,
4C6B
,
6HFI
,
4C6M
,
4C6C
,
4C6N
,
6HFK
,
6HFJ
,
6HG1
,
6HFU
,
4C6O
,
4C6D
,
6HFN
,
4C6E
,
4C6P
,
4C6F
,
6HFL
,
6HFD
,
4C6Q
,
5YNZ
,
4BY3
,
5G1N
,
6HFE
,
4C6I
,
6HFQ
,
4C6J
,
6HFP
IntEnz
3.5.2.3
HPA
ENSG00000084774-CAD
GeneCards
P27708
Ensembl
ENST00000264705
,
ENSP00000264705
,
ENSG00000084774
Pharos - Targets
P27708
Orphanet
23690
ZINC - Predictions - Purchasable
PYR1_HUMAN
HMDB Protein
HMDBP03298
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.725
4
UniProt:Q99558 MAP3K14
5
p-T559-MAP3K14 [cytosol]
(R-HSA-5668531)
Active NIK [cytosol]
(R-HSA-5607646)
MAP3K14 [cytosol]
(R-HSA-168189)
p-MAP3K14 [cytosol]
(R-HSA-168187)
K48polyUb-NIK [cytosol]
(R-HSA-5668525)
0.669
3
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.527
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
3
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