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TRAIL signaling
Stable Identifier
R-HSA-75158
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TRAIL signaling (Homo sapiens)
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Tumor necrosis factor-related apoptosis-inducing ligand or Apo 2 ligand (TRAIL/Apo2L) is a member of the tumor necrosis factor (TNF) family. This group of apoptosis induction pathways all work through protein interactions mediated by the intracellular death domain (DD), encoded within the cytoplasmic domain of the receptor. TRAIL selectively induces apoptosis through its interaction with the Fas-associated death domain protein (FADD) and caspase-8/10 (Wang S & el-Deiry WS 2003; Sprick MR et al. 2002). TRAIL and its receptors, TRAIL-R1 and TRAIL-R2, were shown to be rapidly endocytosed via clathrin-dependent and -independent manner in human Burkitt's lymphoma B cells (BJAB) (Kohlhaas SL et al. 2007). However, FADD and caspase-8 were able to bind TRAIL-R1/R2 in TRAIL-stimulated BJAB cells at 4
o
C (at which membrane trafficking is inhibited), suggesting that the endocytosis was not required for an assembly of the functional TRAIL DISC complex. Moreover, blocking of clathrin-dependent endocytosis did not interfere with the capacity of TRAIL to promote apoptosis (Kohlhaas SL et al. 2007).
Literature References
PubMed ID
Title
Journal
Year
14634624
TRAIL and apoptosis induction by TNF-family death receptors
el-Deiry, WS
,
Wang, S
Oncogene
2003
Participants
Events
TRAIL binds TRAIL receptors
(Homo sapiens)
Trimerization of TRAIL:TRAIL receptor complex
(Homo sapiens)
TRAIL:TRAIL receptor trimers bind FADD
(Homo sapiens)
TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8
(Homo sapiens)
TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10
(Homo sapiens)
TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2
(Homo sapiens)
Participates
as an event of
Death Receptor Signaling (Homo sapiens)
Orthologous Events
TRAIL signaling (Gallus gallus)
TRAIL signaling (Mus musculus)
TRAIL signaling (Rattus norvegicus)
TRAIL signaling (Sus scrofa)
Cross References
BioModels Database
BIOMD0000000220
Authored
Gillespie, ME (2004-08-31)
Reviewed
Salvesen, GS (2013-05-22)
Pop, C (2013-05-22)
Created
Tschopp, J (2004-01-28)
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